Study explores SARS-CoV-2 antibody responses in mild COVID-19 cases
In a new study, researchers evaluated antibody responses in mild cases of coronavirus disease 2019. // 26.4.2022
Corona in general
In-person schooling and associated COVID-19 risk in the United States over spring semester 2021
// 20.4.2022
Waning antibody responses in SARS-CoV-2-infected children and adults over time
In a new study, researchers evaluated the duration of antibodies against SARS-CoV-2. // 20.4.2022
SARS-CoV-2 infection patterns in olfactory epithelium
Researchers assess changes in the respiratory and olfactory epithelium of the nasal mucosa in SARS-CoV-2 infections by the WA1, Delta, and Omicron strains. // 18.4.2022
The brain's reaction to COVID's inflammatory tidal wave
Researchers study neuroinflammation in the cerebrospinal fluid and serum of patients infected with SARS-CoV-2. // 18.4.2022
Ivermectin Does Not Improve COVID-19 Outcomes
Ivermectin neither reduced hospital admissions for worsening COVID-19 nor shortened the time that infected patients spent in the emergency room, according to data from a large randomized controlled trial. // 11.4.2022
Evidence of an increased risk of neurodegeneration after SARS-CoV-2 infection
The current coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a major threat to global health. // 11.4.2022
COVID-19 increases risk of bleeding, DVT, and pulmonary embolism
The ongoing pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a high mortality rate, with acute respiratory distress syndrome (ARDS) with pneumonia being the most... // 11.4.2022
Brain Inflammation and Intracellular α-Synuclein Aggregates in Macaques after SARS-CoV-2 Infection
SARS-CoV-2 causes acute respiratory disease, but many patients also experience neurological complications. Neuropathological changes with pronounced neuroinflammation have been described in individuals after lethal COVID-19, as well as in the CSF of hospitalized patients with neurological complications. // 8.4.2022
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
Nature - FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation // 6.4.2022
COVID boosters protect you better than monoclonal antibodies, or natural infection
In a new study published in the journal Science Translational Medicine, researchers analyzed the neutralization of the Omicron BA.1 variant pseudovirus by post-vaccination serum samples. // 6.4.2022
Severe COVID linked to RAAS and hyperlipidemia associated metabolic syndrome conditions
A recent study posted to the medRxiv* preprint server investigated the association of renin-angiotensin-aldosterone system (RAAS)-mediated hypertension (HT) with coronavirus disease 2019 (COVID-19). // 6.4.2022
Morbidity and Mortality Weekly Report (MMWR) Cardiac Complications After SARS-CoV-2 Infection and mRNA COVID-19 Vaccination — PCORnet, United States, January 2021–January 2022
https://www.cdc.gov/mmwr/volumes/71/wr/mm7114e1.htm?s_cid=mm7114e1_w#T1_down
// 1.4.2022
Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to present with pulmonary and extra-pulmonary organ complications. In comparison with the 2009 pandemic (pH1N1), SARS-CoV-2 infection is likely to lead to more severe disease, with multi-organ effects, including cardiovascular disease. SARS-CoV-2 has been associated with acute and long-term cardiovascular disease, but the molecular changes govern this remain unknown. In this study, we investigated the landscape of cardiac tissues collected at rapid autopsy from SARS-CoV-2, pH1N1, and control patients using targeted spatial transcriptomics approaches. Although SARS-CoV-2 was not detected in cardiac tissue, host transcriptomics showed upregulation of genes associated with DNA damage and repair, heat shock, and M1-like macrophage infiltration in the cardiac tissues of COVID-19 patients. The DNA damage present in the SARS-CoV-2 patient samples, were further confirmed by gamma-H2Ax immunohistochemistry. // 31.3.2022
Effect of Early Treatment with Ivermectin among Patients with Covid-19 | NEJM
Original Article from The New England Journal of Medicine — Effect of Early Treatment with Ivermectin among Patients with Covid-19 // 30.3.2022
Endemicity is not a victory: the unmitigated downside risks of widespread SARS-CoV-2 transmission
We have entered a new phase of the ongoing COVID-19 pandemic, as the strategy of relying solely on the current SARS-CoV-2 vaccines to bring the pandemic to an end has become infeasible. In response, public-health authorities in many countries have advocated for a strategy of using the vaccines to limit morbidity and mortality while permitting unchecked SARS-CoV-2 spread ("learning to live with the disease"). // 30.3.2022
Effectiveness of a 'test-and-treat' approach for identification and treatment of vitamin D insufficiency for prevention of COVID-19
Researchers determined the impact of vitamin D status in preventing all-cause acute respiratory infection and SARS-CoV-2 infection. // 25.3.2022
Combination of Covid-19 and flu linked to greater risk of severe disease, death
Adults in hospital who have Covid-19 and the flu at the same time are at much greater risk of severe disease and death compared with patients who have Covid-19 alone or with other viruses, research shows. // 27.3.2022
Estimating time-dependent infectious contact: a multi-strain epidemiological model of SARS-CoV-2 on the island of Ireland
Mathematical modelling plays a key role in understanding and predicting the epidemiological dynamics of infectious diseases. We construct a flexible discrete-time model that incorporates multiple viral strains with different transmissibilities to estimate the changing infectious contact that leads to new infections during the COVID-19 pandemic. // 25.3.2022
Study Links COVID-19 to Autoimmune and Vascular Diseases
Information regarding development of autoimmune disease following SARS-CoV-2 infection has been limited, according to one of the investigators. // 26.3.2022
Diabetes and High SARS-CoV-2 Viral Load a Deadly Combination in ICU Patients
In COVID-19 patients, a high viral load (SARS-CoV-2 RNAemia) on admission to the ICU is common in patients with diabetes and strongly associated with poor outcome, suggests a study from France. // 24.3.2022
Blood Clots More Likely With COVID Versus Pneumonia
More testing needed in COVID patients, researchers say // 24.3.2022
Differences in neuroinflammation in the olfactory bulb between D614G, Delta and Omicron BA.1 SARS-CoV-2 variants in the hamster model
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with various neurological complications. SARS-CoV-2 infection induces neuroinflammation in the central nervous system (CNS), whereat the olfactory bulb seems to be involved most frequently. Here we show differences in the neuroinvasiveness and neurovirulence among SARS-CoV-2 variants in the hamster model five days post inoculation. // 24.3.2022
Burden of PCR-Confirmed SARS-CoV-2 Reinfection in the U.S. Veterans Administration, March 2020 – January 2022
// 23.3.2022
Association of COVID-19 with risks of hospitalization and mortality from other disorders post-infection: A study of the UK Biobank
Background More than 0.4 billion cases of COVID-19 have been reported worldwide. The sequalae of COVID-19 remains unclear, especially whether it may be associated with increased hospitalization and mortality from other diseases. // 23.3.2022
Risk of death following SARS-CoV-2 infection or COVID-19 vaccination in young people in England: a self-controlled case series study
Objectives: To assess whether there is a change in the incidence of cardiac and all-cause death in young people following COVID-19 vaccination or SARS-CoV-2 infection in unvaccinated individuals. // 23.3.2022
Risk of SARS-CoV-2 transmission by fomites: a clinical observational study in highly infectious COVID-19 patients
Background: The contribution of droplet-contaminated surfaces for virus transmission has been discussed controversially in the context of the current Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic. Importantly, the risk of fomite-based transmission has not been systematically addressed. // 23.3.2022
Assessment of cardiovascular & pulmonary pathobiology in vivo during acute COVID-19
Importance: Acute COVID19 related myocardial, pulmonary and vascular pathology, and how these relate to each other, remains unclear. No studies have used complementary imaging techniques, including molecular imaging, to elucidate this. // 22.3.2022
Immune and Clotting Dysfunction Detected in Saliva and Blood Plasma after COVID-19
It is becoming increasingly clear that individuals recovered from acute coronavirus disease 2019 (COVID-19) can develop into long-term sequelae (post-acute sequala of SARS-CoV-2 infection, PACS). While antibody response kinetics against viral particles is well studied in natural infection and vaccine, the molecular mechanisms governing disease formation remain elusive. // 21.3.2022
Cost-effectiveness of antigen testing for ending COVID-19 isolation
Background The Omicron variant of SARS-CoV-2 led to a steep rise in transmissions. Recently, as public tolerance for isolation abated, CDC guidance on duration of at-home isolation of COVID-19 cases was shortened to five days if no symptoms, with no lab test requirement, despite more cautious approaches advocated by other federal experts. // 21.3.2022