Inactivated polio vaccine induces antibodies that block SARS-CoV-2 RNA synthesis
A new study introduces the possibility that the inactivated polio vaccine can elicit antibodies that inhibit SARS-CoV-2 nucleic acid synthesis. // 10.10.2021
Powerful neutralizing antibody against SARS-CoV-2 variants of concern
A new paper discusses a new antibody with potent neutralizing activity against the ancestral SARS-CoV-2 strain, as well as newer variants of SARS-CoV-2. // 10.10.2021
Study shows an association between initial SARS-CoV-2 viral load and disease severity
Researchers investigated the utility of initial SARS-CoV-2 viral loads of tests performed at a Public Health testing facility regarding hospital and ICUs admissions and overall survival. // 8.10.2021
Researchers find the differences in COVID antibody responses to vaccination and natural infection
Hope for a future without fear of COVID-19 comes down to circulating antibodies and memory B cells. Unlike circulating antibodies, which peak soon after vaccination or infection only to fade a few months later, memory B cells can stick around to prevent severe disease for decades.
“While a natural infection may induce maturation of antibodies with broader activity than a vaccine does-;a natural infection can also kill you. A vaccine won't do that and, in fact, protects against the risk of serious illness or death from infection." // 8.10.2021
Scientists study immune response to COVID-19 in patients with different levels of disease severity
Researchers from Skoltech, U.S. companies VirIntel and Argentys Informatics, and two Russian Academy of Sciences institutes have studied the immune response to COVID-19 in patients with different levels of disease severity. // 8.10.2021
The ongoing COVID-19 pandemic brought about by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has also been responsible for various cutaneous manifestations. Among them, chilblain-like lesions (CLL) have been found to occur more frequently. // 8.10.2021
Critical function of IL-7 in diagnosis, prognosis, and treatment of COVID-19 patients
In this review, researchers summarized the therapeutic and pathogenic role of IL-7 in patients with COVID-19 and examined the promising role of IL-7 as a vaccine adjuvant. // 7.10.2021
Study suggests continued delta variant outbreaks unless vaccination reaches high coverage levels in adults and children
Researchers have conducted a mathematical modeling study to understand how expanding vaccination to younger age groups may reduce the increasing case numbers. // 7.10.2021
Study shows new antibody resistant variants can emerge in patients treated with monoclonal antibodies
A new study, published on the medRxiv* preprint server, suggested that selective pressures induced by the administration of monoclonal antibodies (Bamlanivimab) may require increased genomic surveillance to identify and control the spread of therapy-induced variants. // 6.10.2021
SARS-CoV-2 evolution promoted by long-term infection in patient with B cell depletion
A new study published on the medRxiv* preprint server focused on a patient with a persistent symptomatic viral infection for over a year. Researchers amplified sub-genomic transcripts for the E gene (sgE) using nasopharyngeal samples of the patient infected with SARS-CoV-2 over the course of 335 days. // 6.10.2021
The current study used data on the durability of immunity among evolutionarily close coronavirus relatives of SARS-CoV-2 to estimate times to reinfection. // 6.10.2021
Study shows strong protective effect of IgG3 antibodies in SARS-CoV-2 infection
Researchers published a study on the expression and functional analyses of a neutralizing mAb with identical variable domains but different constant HCs, representing IgG1-4. // 6.10.2021
Koronavirus | ECDC:n raportti: Suomi kuuluu maihin, joissa alhainen rokotustaso voi aiheuttaa tartuntojen lisääntymistä ja sairaaloiden kuormittumista
Terveyden ja hyvinvoinnin laitoksen (THL) johtava asiantuntija Mia Kontio kertoo, ettei Suomen jääminen EU- ja ETA-maiden keskiarvon alle ollut yllätys. // 6.10.2021
What is the frequency of COVID testing to prevent Delta variant transmission?
In a new study published on the medRxiv* preprint server, scientists have used available data on the Delta variant’s viral load to infer its infectiousness and, subsequently, estimate the reduction in its transmission brought about by surveillance testing. // 6.10.2021
Morbidity and Mortality Weekly Report (MMWR) Association Between COVID-19 and Myocarditis Using Hospital-Based Administrative Data — United States, March 2020–January 2021 Weekly
Viral infections are a common cause of myocarditis. Some studies have indicated an association between COVID-19 and myocarditis. // 3.10.2021
Research highlights challenges in utilizing Ct data to guide COVID-19 clinical planning
In a new study, a collaboration of researchers from various institutes described the natural history of SARS-CoV-2 testing, which includes Ct values among patients who had tested positive multiple times, prior to the emergence of VOCs in the vaccine roll-out. In addition, the authors analyze the timescale of positivity and clinical features of the population of patients with prolonged SARS-CoV-2 positivity. // 5.10.2021
Plasmid DNA vaccines induce effective antibody responses against SARS-CoV-2 in mice
Researchers in the United States and China have developed plasmid DNA immunogens that induce effective antibody responses in mice against the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19). // 5.10.2021
Emergence and evolution of endemic and emerging coronavirus diversity in humans and animals
A study aimed to understand the evolutionary and epidemiology dynamics of coronavirus diversity in animals, humans, and wildlife at ecosystem interfaces. // 5.10.2021
Connection between aerosol transmission and COVID-19 dynamics
A simulation study explored event-level overdispersion of SARS-Cov-2 spread, utilizing real-world inputs from a large number of social gatherings. // 5.10.2021