Predicting immunity evasion of SARS-CoV-2 Omicron variant of concern
In a new study, a team of researchers assessed the affinity of the SARS-CoV-2 Omicron variant of concern towards major histocompatibility complex (MHC) binding // 4.2.2022
Review confirms reduced severity of SARS-CoV-2 Omicron infection
Researchers review existing literature to quantify the transmissibility, immune evasion, reinfection, and severity of the SARS-CoV-2 Omicron variant. // 3.2.2022
BA.2 sublineage of Omicron shows increased immune evasion and transmission
Recently, researchers from the University of Copenhagen have been investigating the spread of two sublineages of the Omicron variant among Danish households. // 31.1.2022
Growth advantage of SARS-CoV-2 Omicron variant found to be partly due to shorter serial interval
In a new study, a team of researchers assessed how serial intervals of SARS-CoV-2 Omicron and Delta variants varied during the same time period in the Netherlands. // 25.1.2022
Danish study shows lower risk of hospitalization in Omicron cases compared to Delta
In a recent study posted to the Preprints with The Lancet* server, a large team of researchers estimated the comparative risk of hospitalization after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron and Delta variants of concern (VOCs) in Denmark. // 24.1.2022
In Portugal risk of hospitalization from Omicron is 75% lower than Delta
Researchers from Portugal reported a 75% risk reduction in hospitalizations for individuals infected with Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared to the Delta variant and a shorter length of stay and lower mortality if hospitalization does occur. // 24.1.2022
Study shows how SARS-CoV-2 Omicron evades our immune response and remains infective
A recent study published in the journal Science brings a detailed chemical and molecular perspective on the improved evasion of antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the retention of strong interactions with the receptor as two principal factors underneath the notorious transmissibility of the SARS-CoV-2 Omicron variant. // 23.1.2022
Omicron found to have higher environmental stability among SARS-CoV-2 variants
A new study compared the SARS-CoV-2 Wuhan strain and all the variants of concern (VOCs) - Alpha, Beta, Delta, and Omicron variants for their survivability and infectivity. // 21.1.2022
SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex
The newly reported Omicron variant is poised to replace Delta as the most prevalent SARS-CoV-2 variant across the world. Cryo-EM structural analysis of the Omicron variant spike protein in complex ... // 20.1.2022
Scientists assess ACE2 binding and antigenicity of Mu (B.1.621) and A.2.5 spikes
To gain a better understanding of the antigenic properties of Mu and A.2.5 Spikes, Canadian scientists evaluated their capacity to interact with ACE2 and performed binding and neutralization assays with plasma from vaccinated individuals. // 18.1.2022
Analyzing disease severity of SARS-CoV-2 Omicron variant using RNA dependent RNA polymerase target delay
In a new study, a team of researchers compared the severity of the SARS-CoV-2 Omicron variant to the Delta variant using the PCR proxy marker of RNA dependent RNA polymerase target delay. // 18.1.2022
Mutations in SARS-CoV-2 Omicron variant promote cell binding
Researchers in Germany, based on their recent study published in the journal ChemBioChem, have proposed that the elevated occurrence of positively charged amino acids in specific domains of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) Omicron variant spike protein improves viral binding to cellular negatively charged receptors aiding in enhanced infectiousness. // 16.1.2022
SARS-CoV-2 Omicron variant's infectivity, vaccine breakthrough, and antibody resistance
A recent study uses an artificial intelligence model to investigate Omicron's mutations and its infectivity, vaccine escape capability, and susceptibility to monoclonal antibodies. // 10.1.2022
SARS-CoV-2 Delta sublineage AY.4.2 shows no increase in cell entry or antibody evasion
Researchers from Germany, in their recent study published in the journal Cellular & Molecular Immunology, have evaluated the mutations in the S protein of one such SARS-CoV-2 strain, a Delta sublineage AY.4.2, which is currently expanding in the UK, and have found that it neither contains any potential for increased cell entry nor antibody escape. // 10.1.2022
SARS-CoV-2 Omicron belongs to new antigenic cluster compared to all other VOCs
Researchers investigate SARS-CoV-2 antigenic drift by evaluating the neutralizing activity of sera from patients infected with all five SARS-CoV-2 VOCs. // 6.1.2022
A new research paper posted as a preprint to the bioRxiv* server attempts to throw some light on this question by studying viral pathogenicity in golden hamsters, a valuable model for severe COVID-19 due to the development of reproducible weight loss and pneumonia after infection with the virus. // 6.1.2022
Scientists estimate transmission advantage of Omicron over Delta variant as +105%
Researchers use statistical models to assess the transmission of the SARS-CoV-2 Omicron using variant-specific screening tests and genome sequencing. // 5.1.2022
A new model for predicting COVID-19 severity at diagnosis
Researchers estimate the probabilities of hospitalization and mortality from COVID-19 according to individual risk factors and number of vaccine doses. // 5.1.2022
Study findings suggest spread of Omicron can be ascribed to immune evasiveness rather than an increase in transmissibility
Researchers investigate the household transmission of the Omicron VOC and increased immune evasiveness of both the Omicron and Delta variants // 5.1.2022
Characteristics and outcomes in patients hospitalized with COVID-19 in South Africa
A new research letter assessed patients hospitalized with a positive SARS-CoV-2 test during the fourth wave compared to the previous waves. // 4.1.2022
Very high rates of asymptomatic infection with Omicron compared to prior SARS-CoV-2 variants
The advent of the B.1.1.529 (Omicron) severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) variant, detected initially in Botswana and South Africa and now found in over 135 countries as of January 3, 2022, has sparked fears of a new global wave of infections and hospitalizations // 3.1.2022
SARS-CoV-2 Omicron study on hamsters, shows virus results in a less severe disease
Researchers investigate the ability of immunity acquired from SARS-CoV-2 wild-type infection to protect against the Omicron variant in Syrian hamster models. // 3.1.2022