Bacillus anthracis Spore Inactivation by Fumigant Decontamination
Evaluation of Chlorine Dioxide Gas and Peracetic Acid Fog for the Decontamination of a Mock Heating, Ventilation, and Air Conditioning Duct System ~US EPA
Techniques for bsc decontamination ~DRS Laboratories
" Chlorine Dioxide: Use Geobacillus stearothermophilus as BI (?)" "The Halide Group, ClorDiSys Solutions, Sabre Technologies (different reaction)" "--“True gas – no condensation issues" "Mild corrosion/discoloring to cold steel, copper, brass: Particularly in the presence of water.
Potentially corrosive if Chlorine gas (Cl2) is present
-- Care to avoid Cl2 in synthesized CD
-- Care to avoid Cl2 creation by UV exposure" "Typical duration conditioning through
decontamination: 1-1.5 hr. Typical duration of aeration / scrubbing: 0.25-0.5 hr"
Methods of using chlorine dioxide as a fumigant - Google Patents
"The initial rate is high to provide sufficient chlorine dioxide to penetrate the various surfaces demands within the volume requiring fumigation. This rate is predetermined to accommodate the surface demand as well as to provide the initial charge of the volume requiring fumigation to a predetermined chlorine dioxide residual level. The chlorine dioxide generation rate is then reduced appropriately to maintain the predetermined chlorine dioxide concentration in the air of the volume requiring fumigation for a predetermined time. This can be achieved by a number of means, such as lowering the concentration of chlorine dioxide in the solution that is fed to the emitter, or lowering the flow rate of the chlorine dioxide solution to the emitter." "If the space to be fumigated contains materials that are potentially susceptible to corrosion, the chlorine dioxide should be of the highest possible purity. Specifically, chlorine gas should be present in the introduced gas at a level less than about 5%" "Typically, if the enclosed volume is 2280 ft3, air is suitably recirculated at 5 CFM"
Fumigation: Choose Your Weapon!
**** "ClO2 struggled to be accepted initially as a fumigant because of fears over its potential corrosiveness and toxicity. It is ***not considered a substance of concern by the ECHA, so is exempt from BPR PT2***. ClO2 fumigations are actually not corrosive, but a controlled study by the US EPA showed it can be corrosive inside functioning computers due to the heat from the CPU" "study gives this system the thumbs up in terms of its efficacy and reliability in comparison with formaldehyde against a range of tough-to-kill pathogens and spores. It is also excellent at inactivating beta-lactams" [Note: Fogging of chlorine dioxide liquid solution likely results in greater concentrations in some areas of room for at least some of the time. How much might variations in humidity throughout a room result in variations in chlorine dioxide concentrations in different areas when chlorine dioxide gas is emitted separately from any liquid?): "The other main advantages of this [hydrogen peroxide/ peracetic acid] system are that the room humidity does not need to be raised pre-fumigation, so there is little chance of the chemical pooling in cooler areas."
Document Display | NEPIS | US EPA
"Two of the three computers in the 75 ppmv ClO2 75 percent run had surviving spores. The three computers that had condensing conditions due to a faulty valve... had a 100 percent kill rate."
Clordisys material compatibility brochure 3097787
{ClorDiSys} "One of the very rst commercial uses for our chlorine dioxide gas was for the sterilization of implantable contact lenses, where it was proven to the FDA that there were no measureable residuals"
Evaluation of Sporicidal Decontamination Technology: Sabre Technical Services Chlorine Dioxide Gas Generator | Science Inventory | US EPA
[Includes full download "Evaluation of Chlorine Dioxide Gas Generator: Evaluation of Sporicidal"] The objective of testing the Sabre chlorine dioxide gas generator was to evaluate its ability to decontaminate Bacillus anthracis Ames spores and two surrogates, Bacillus subtilis (ATCC 19659) and Geobacillus stearothermophilus (ATCC 12980), on indoor surface materials."
Decontamination of Bacillus thuringiensis spores on selected surfaces by chlorine dioxide gas - PubMed
****!!!!****!!!! "Under the tested treatment conditions, the highest population of surviving spores was found on the paper surface and the lowest was found on the plastic surface (p .05). The 5 mg/L ClO2 gas treatment inactivated 2.5, 3.6, 4.0, and 4.9 log spores per surface on paper, wood, epoxy, and plastic surfaces, respectively. A greater than 5-log reduction of spores was achieved on each surface after the 15 mg/L ClO2 gas treatment. The minimum ClO2 gas concentration needed to completely inactivate the inoculated spores was 30 mg/L for paper and wood surfaces, 25 mg/L for epoxy surfaces, and 20 mg/L for plastic surfaces."
Isolator Decontamination Using Chlorine Dioxide Gas ~ClorDiSys
"CD was highly efficacious in reducing B. subtillis spores onpaper, plastic, epoxy-coated stainless steel, and wood surfaces(7). In addition, no corrosion was observed when using pharmaceutical-type materials such as 316 and 304 series stain-less steel, Lexan, and other commonly used plastics includingDelrin, Teflon, UHMWPE, Viton, and PVC (8). In a separatestudy, postexposure rinses of 304 stainless steel coupons inwater-for-injection showed no residual CD when measuredwith a high-pressure liquid chromatographic method for chlo-ride detection"