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Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses
Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses
Dec 2020. *****!!!!!****!!!*** We find SARS-CoV-2 survives longest at low temperatures and extreme relative humidities; median estimated virus half-life is over 24 hours at 10 °C and 40 % RH, but approximately 1.5 hours at 27 °C and 65 % RH."
·biorxiv.org·
Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses
Dynamics of airborne influenza A viruses indoors and dependence on humidity - PubMed
Dynamics of airborne influenza A viruses indoors and dependence on humidity - PubMed
There is mounting evidence that the aerosol transmission route plays a significant role in the spread of influenza in temperate regions and that the efficiency of this route depends on humidity. Nevertheless, the precise mechanisms by which humidity might influence transmissibility via the aerosol r …
·pubmed.ncbi.nlm.nih.gov·
Dynamics of airborne influenza A viruses indoors and dependence on humidity - PubMed
Influenza A virus is transmissible via aerosolized fomites | Nature Communications
Influenza A virus is transmissible via aerosolized fomites | Nature Communications
We provide evidence of a mode of transmission seldom considered for influenza: airborne virus transport on microscopic particles called “aerosolized fomites.” In the guinea pig model of influenza virus transmission, we show that the airborne particulates produced by infected animals are mainly non-respiratory in origin. Surprisingly, we find that an uninfected, virus-immune guinea pig whose body is contaminated with influenza virus can transmit the virus through the air to a susceptible partner in a separate cage. We further demonstrate that aerosolized fomites can be generated from inanimate objects, such as by manually rubbing a paper tissue contaminated with influenza virus. Our data suggest that aerosolized fomites may contribute to influenza virus transmission in animal models of human influenza, if not among humans themselves, with important but understudied implications for public health.
·nature.com·
Influenza A virus is transmissible via aerosolized fomites | Nature Communications
Indoor air humidity, air quality, and health - An overview - PubMed
Indoor air humidity, air quality, and health - An overview - PubMed
There is a long-standing dispute about indoor air humidity and perceived indoor air quality (IAQ) and associated health effects. Complaints about sensory irritation in eyes and upper airways are generally among top-two symptoms together with the perception "dry air" in office environments. This call …
·pubmed.ncbi.nlm.nih.gov·
Indoor air humidity, air quality, and health - An overview - PubMed
Fate of respiratory droplets in tropical vs temperate environments and implications for SARS-CoV-2 transmission
Fate of respiratory droplets in tropical vs temperate environments and implications for SARS-CoV-2 transmission
The new pandemic of SARS-CoV-2 has shown stark differences in number of affected patients between countries in the tropics and those with temperate environments. Though there have been many theories on reasons for these differences, we hypothesise that ...
·ncbi.nlm.nih.gov·
Fate of respiratory droplets in tropical vs temperate environments and implications for SARS-CoV-2 transmission
Transmissibility of COVID-19 in 11 major cities in China and its association with temperature and humidity in Beijing, Shanghai, Guangzhou, and Chengdu
Transmissibility of COVID-19 in 11 major cities in China and its association with temperature and humidity in Beijing, Shanghai, Guangzhou, and Chengdu
The new coronavirus disease COVID-19 began in December 2019 and has spread rapidly by human-to-human transmission. This study evaluated the transmissibility of the infectious disease and analyzed its association with temperature and humidity to study ...
·ncbi.nlm.nih.gov·
Transmissibility of COVID-19 in 11 major cities in China and its association with temperature and humidity in Beijing, Shanghai, Guangzhou, and Chengdu
Mechanistic insights into the effect of humidity on airborne influenza virus survival, transmission and incidence
Mechanistic insights into the effect of humidity on airborne influenza virus survival, transmission and incidence
Influenza incidence and seasonality, along with virus survival and transmission, appear to depend at least partly on humidity, and recent studies have suggested that absolute humidity (AH) is more important than relative humidity (RH) in modulating observed ...
·ncbi.nlm.nih.gov·
Mechanistic insights into the effect of humidity on airborne influenza virus survival, transmission and incidence
Predictors of indoor absolute humidity and estimated effects on influenza virus survival in grade schools
Predictors of indoor absolute humidity and estimated effects on influenza virus survival in grade schools
Low absolute humidity (AH) has been associated with increased influenza virus survival and transmissibility and the onset of seasonal influenza outbreaks. Humidification of indoor environments may mitigate viral transmission and may be an important control ...
·ncbi.nlm.nih.gov·
Predictors of indoor absolute humidity and estimated effects on influenza virus survival in grade schools
Modeling the airborne survival of influenza virus in a residential setting: the impacts of home humidification
Modeling the airborne survival of influenza virus in a residential setting: the impacts of home humidification
Laboratory research studies indicate that aerosolized influenza viruses survive for longer periods at low relative humidity (RH) conditions. Further analysis has shown that absolute humidity (AH) may be an improved predictor of virus survival in the environment. ...
·ncbi.nlm.nih.gov·
Modeling the airborne survival of influenza virus in a residential setting: the impacts of home humidification
On the interpretation of bioaerosol exposure measurements and impacts on health
On the interpretation of bioaerosol exposure measurements and impacts on health
(2019). "deeper understanding and more efficient utilization of bioaerosol studies to prevent public health hazards" "Mycotoxins, defined as secondary metabolites of fungi, are harmful indoor-air contaminants associated with mold growth in buildings and are known to cause several diseases such as cancer, hepatitis, and nephritis (Jarvis and Miller 2005). A component in the cell wall of fungi, (1→3)-β-d-glucan, is believed to play a role in pulmonary inflammation, increased sensitivity to endotoxins, and pulmonary embolisms."
·tandfonline.com·
On the interpretation of bioaerosol exposure measurements and impacts on health
The effects of regional climatic condition on the spread of COVID-19 at global scale
The effects of regional climatic condition on the spread of COVID-19 at global scale
The pandemic outbreak of the novel coronavirus epidemic disease (COVID-19) is spreading like a diffusion-reaction in the world and almost 208 countries and territories are being affected around the globe. It became a sever health and socio-economic problem, ...
·ncbi.nlm.nih.gov·
The effects of regional climatic condition on the spread of COVID-19 at global scale
Influence of wind and relative humidity on the social distancing effectiveness to prevent COVID-19 airborne transmission: A numerical study - PubMed
Influence of wind and relative humidity on the social distancing effectiveness to prevent COVID-19 airborne transmission: A numerical study - PubMed
It has been confirmed that the coronavirus disease 2019 (COVID-19) can transmit through droplets created when an infected human coughs or sneezes. Accordingly, 1.83-m (6-feet) social distancing is advised to reduce the spread of the disease among humans. This is based on the assumption that no air c …
·pubmed.ncbi.nlm.nih.gov·
Influence of wind and relative humidity on the social distancing effectiveness to prevent COVID-19 airborne transmission: A numerical study - PubMed
Humidifier fever
Humidifier fever
MRC Symposium (1977).Thorax, 32, 653-663. Humidifier fever. In enclosed environments, it may be necessary to regulate temperature, ventilation, and humidity to maintain comfortable working conditions. Several systems can be used although in terms of installation ...
·ncbi.nlm.nih.gov·
Humidifier fever
Turbulent Gas Clouds and Respiratory Pathogen Emissions -- Potential Implications for Reducing Transmission of COVID-19
Turbulent Gas Clouds and Respiratory Pathogen Emissions -- Potential Implications for Reducing Transmission of COVID-19
This JAMA Insights Clinical Update discusses the need to better understand the dynamics of respiratory disease transmission by better characterizing transmission routes, the role of patient physiology in shaping them, and best approaches for source control in the context of the COVID-19 outbreak.
·jamanetwork.com·
Turbulent Gas Clouds and Respiratory Pathogen Emissions -- Potential Implications for Reducing Transmission of COVID-19
Review of indoor aerosol generation, transport, and control in the context of COVID‐19
Review of indoor aerosol generation, transport, and control in the context of COVID‐19
The coronavirus disease‐2019 (COVID‐19) pandemic has heightened the awareness of aerosol generation by human expiratory events and their potential role in viral respiratory disease transmission. Concerns over high severe acute respiratory ...
·ncbi.nlm.nih.gov·
Review of indoor aerosol generation, transport, and control in the context of COVID‐19
Mechanisms by Which Ambient Humidity May Affect Viruses in Aerosols
Mechanisms by Which Ambient Humidity May Affect Viruses in Aerosols
{Viruses-- probly applies to SARS-COV-2} Many airborne viruses have been shown to be sensitive to ambient humidity, yet the mechanisms responsible for this phenomenon remain elusive. We review multiple hypotheses, including water activity, surface inactivation, and salt toxicity, that may account for the association between humidity and viability of viruses in aerosols. We assess the evidence and limitations for each hypothesis based on findings from virology, aerosol science, chemistry, and physics. In addition, we hypothesize that changes in pH within the aerosol that are induced by evaporation may trigger conformational changes of the surface glycoproteins of enveloped viruses and subsequently compromise their infectivity. This hypothesis may explain the differing responses of enveloped viruses to humidity. The precise mechanisms underlying the relationship remain largely unverified, and attaining a complete understanding of them will require an interdisciplinary approach.
·aem.asm.org·
Mechanisms by Which Ambient Humidity May Affect Viruses in Aerosols
Advanced Analysis to Distinguish between Physical Decrease and Inactivation of Viable Phages in Aerosol by Quantitating Phage-Specific Particles - PubMed
Advanced Analysis to Distinguish between Physical Decrease and Inactivation of Viable Phages in Aerosol by Quantitating Phage-Specific Particles - PubMed
Recent studies have investigated the efficacy of air-cleaning products against pathogens in the air. A standard method to evaluate the reduction in airborne viruses caused by an air cleaner has been established using a safe bacteriophage instead of pathogenic viruses; the reduction in airborne viru …
·pubmed.ncbi.nlm.nih.gov·
Advanced Analysis to Distinguish between Physical Decrease and Inactivation of Viable Phages in Aerosol by Quantitating Phage-Specific Particles - PubMed