General toxicity studies of chlorine dioxide and by-products of chloride and chlorates in water
****!!!****!!!!!*** 2001 {Tests on rats} "The acute toxicity and build-up toxicity of mice were tested by Horn's method and accumulation coefficient method, and the acute toxicity and accumulation toxicity of mice were studied through 90-day feeding tests on rats Subchronic toxicity of ClO2 and its by-products ClO-2 and ClO-3 mixed aqueous solutions, including weight gain, food utilization, hematological indicators, serum biochemical indicators, statistical analysis of liver (kidney) /weight ratio variance, and pathological histology microscopy of liver (kidney). The results showed that the ClO2 aqueous solution of 2 76.5mg/l, the NaClO2 and NaClO3 aqueous solution of 2 0 mg/l and the mixed aqueous solution with a total concentration of 553mg/lClO2 were all actual non-toxic aqueous solutions. 2 76.5mg/l ClO2, 2 0 0mg/l NaClO2 and NaClO3 aqueous solutions are also aqueous solutions without significant build-up; ClO2 mixture had no significant effect on weight gain and food utilization in rats (p 0 .0 5); There was no effect on rat hematological indicators such as white blood cell count (WBC) and hemoglobin (Hb) (p 0 .0 5); Tests of glutat-propylene transaminase (ALT), total protein (TP), albumin (ALB) and globulin (GLO) showed no significant difference between the control group and the high-dose group (p 0 .0 5); The liver-to-body ratio (%) and renal ratio (%) of rats in each test group and control group were analyzed by variance, and there was no significant difference between the groups (p 0 .0 5); Pathological histological examination results showed that no lesions were seen in the liver and kidney tissues of the test groups and control groups."