Bed Bugs. Stored Product Beetles. Etc.

****!!!!*** "Devices, compositions, systems and methods for the non-cytotoxic delivery of chlorine dioxide to a tissue." "Cytotoxicity of chlorine dioxide-containing compositions results predominantly from the presence of oxy-chlorine anions, and not from the presence of chlorine, which can be a product of chlorine dioxide decomposition." " mucosal tissue, epidermal tissue, dermal tissue, and subcutaneous tissue (also called hypodermis tissue). Mucosal tissue includes buccal mucosa, other oral cavity mucosa (e.g., soft palate mucosa, floor of mouth mucosa and mucosa under the tongue), vaginal mucosa and anal mucosa... Biological tissue may be intact or may have one or more incisions, lacerations or other tissue-penetrating opening.” "tooth enamel, dentin, fingernails, toe nails, hard keratinized tissues and the like, found in animals" "In some embodiments, the method is practiced on a chronic wound of soft tissue"

Chlorine dioxide has been historically used as a disinfecting agent for drinking water supplies and surfaces. Widespread use as an alternative option for prevention and treatment of COVID-19 has emer...

***!!!***!!! 2021 "blood pressure was 181/57 mm Hg, heart rate of 70 beats per minute, respiratory rate of 20 breaths per minute, and an oxygen saturation of 77% on room air. She appeared cyanotic and reported a burning sensation in her throat. She had no apparent burns to the oropharynx and was not in respiratory distress. Laboratory evaluation revealed a methemoglobin level of 41%. The patient received a single dose of methylene blue 1 mg/kg within one hour of emergency department arrival with rapid improvement in the methemoglobin level." "Over the course of several hours, the patient developed hypoxemic respiratory failure, acute renal failure, and severe intravascular hemolysis. She underwent multiple sessions of intermittent hemodialysis to manage the metabolic acidosis and to potentially remove unbound chlorite. The hemoglobin nadired at 9.6 gm/dL (baseline 13.6 gm/dL). Peripheral blood smear showed ghost cells and schistocytes. Despite aggressive resuscitation and blood transfusions, she developed disseminated intravascular coagulopathy (INR 6.46, undetectable fibrinogen) and died two days following the ingestion."

**** "These observations are of much clinical significance in view of the retention of these products' active agent, i.e. 90 %) may effectively exert its essential microbicidal, anti-periodontal and oral malodour-neutralising actions."

(Citing separate studies...) "This neutralizing property of ClO2, combined with its ability to completely disinfect, makes DIOXIDERM and DIOXIGUARD ideal wound medications. Unlike iodine compounds, healing is not impeded. Veterinarians have been treating deep wounds and abscesses on tigers and elephants as well as dogs and cats with outstanding success. DIOXIDERM GEL had similar striking results on human (otherwise non-healing) diabetic ulcers." "Rats and honeybees were fed ClO2 in high doses over a two year period. No ill effects were noted" " With prolonged feeding toxicity is produced mainly in the red blood cell. Rats fed up to 1000 mg/l chronically for 6 months showed no significant hematological changes. After 9 months, however, red blood cell counts, hematacrit and hemoglobin were decreased in all treatment groups. " "At high ClO2 ppm, the method of rapid bacterial and viral kill appears to be the softening and destroying of the cell wall or viral envelope.53 Human cells do not have cell walls and are apparently unaffected. Our skin and bodies are likely protected from the general oxidative effects of ClO2 by the many reducing agents in our cells and blood such as catalase, glutathione, superoxide dismutase, vitamins E, C, A, B complex, uric acid, zinc and selenium. " "100 ppm 70,71,72, about the concentration of Frontier's DioxiDerm gel for topical us"

"Chlorine dioxide treatment even at 400 ppm for 6 h did not kill any T. castaneum. However, the combined treatment of chlorine dioxide with the heat treatment for 6 h resulted in 95% mortality. These results indicated that heat treatment suppressed the evasive behavior of T. castaneum and synergized the control efficacy of the chlorine dioxide fumigant. "

****!!!!**{Lists several reports of toxicity from chlorine dioxide and sodium chlorite} Patient died 5 days after taking chlorine dioxide orally and intravenuously.

1981. "An epldemioiogic study of 198 persons exposed for 3 months to drinking water disinfected with chlorine dioxide was conducted in a rural village. A control population of 118 nonexposed persons was also studied. Pre-exposure hematologic and serum chemical parameters were compared with test results after 115 days of exposure. Chlorite ion levels In the water averaged approximately 5 ppm during the study period. Statistical analysis (ANOVA) of the data failed to identify any significant exposure-related effects. This study suggests that future evaluations of chlorine dioxide disinfection should be directed toward populations with potentially increased sensitivity to hemo-lytic agents"

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********!!!!!!***** 2015 {Ingestion resulted in oxygen deficiency} "A 1-year-old boy presented to the emergency department with vomiting and poor complexion" "The patient had profound hypoxia that did not respond to oxygen therapy and required endotracheal intubation to maintain a normal oxygen level. Although oxygen saturation (SpO2) fluctuated at approximately 95% after intubation, arterial oxygen pressure (PaO2) was high on arterial blood gas analysis."

"ClO2, the so-called “ideal biocide”, could also be applied as an antiseptic if it was understood why the solution killing microbes rapidly does not cause any harm to humans or to animals." "The killing time for a bacterium is on the order of milliseconds in a 300 ppm ClO2 solution. Thus, a few minutes of contact time (limited by the volatility of ClO2) is quite enough to kill all bacteria, but short enough to keep ClO2 penetration into the living tissues of a greater organism safely below 0.1 mm. Bacteria are not able to develop resistance against ClO2 as it reacts with biological thiols which play a vital role in all living organisms. Conclusion: Selectivity of ClO2 between humans and bacteria is based not on their different biochemistry, but on their different size."

{Note: Some of the conclusions in this paper may not be reliable.} Includes IV treatment & oral doses