Sodium chlorate (NaClO3) is a widely used non-selective herbicide. It is also generated as a byproduct during disinfection of drinking water by chlorine dioxide. In the present work, the effects of NaClO3 on human erythrocytes were studied under in vitro conditions. Incubation of erythrocytes with different concentrations of NaClO3 at 37 °C for 90 min resulted in significant hemolysis. Cell lysates were prepared from NaClO3-treated and untreated (control) erythrocytes and assayed for various biochemical parameters. Methemoglobin levels were significantly increased and methemoglobin reductase activity was reduced upon NaClO3 treatment. There was a significant increase in protein oxidation and lipid peroxidation with a decrease in reduced glutathione and total sulfhydryl content. This suggests the induction of oxidative stress in erythrocytes upon exposure to NaClO3. The occurrence of oxidative stress was confirmed by significantly increased generation of reactive oxygen species and lowered antioxidant response of the cells. NaClO3 treatment also increased nitric oxide levels showing induction of nitrosative stress. The activities of major antioxidant and membrane-bound and metabolic enzymes were significantly altered upon incubation of erythrocytes with NaClO3. The erythrocytes became more osmotically fragile while electron microscopic images showed gross morphological alterations in NaClO3-treated cells. These results show that NaClO3 induces oxidative stress in human erythrocytes, which results in extensive membrane damage and lowers the antioxidant response.

Chlorination of potable water supplies high in organics may yield carcinogenic compounds such as trihalomethanes. Chlorine dioxide has been proposed as an alternative disinfectant to chlorine. However, chlorine dioxide is a strong oxidant that forms significant amounts of chlorite when added to potable water supplies, and chlorite is similar to nitrite in its molecular structure and may be similar in its mechanism of methemoglobin production. Nitrites and chlorites are thought to act synergistically to produce MetHb. Neonates and persons with G-*-PD deficiency are likely to be unusually susceptible to MetHb formation from these compounds because their red cells lack the metabolic machinery to adequately protect against oxidant stress. Since male blacks represent the largest population in the U.S. to be G-6PD deficient, Black male neonates may represent the group at highest risk to the use of chlorine dioxide as a disinfectant in the nations water supplies.

The U.S. Food and Drug Administration (FDA) is warning consumers not to purchase or to use high-strength hydrogen peroxide products, including a product marketed as "35 Percent Food Grade Hydrogen Peroxide," for medicinal purposes because they can cause serious harm or death when ingested. FDA recommends that consumers who are currently using high-strength hydrogen peroxide stop immediately and consult their health care provider.

********"105 to 177 mg/kg (equivalent to 79–133 mg chlorite/kg)"

41-year-old woman of Malay ethnicity who presented with an 11-day history of fever and left-sided lymphadenopathy after consuming ‘Miracle Mineral Solution’ (sodium chlorite solution) for the first time. A ...

"An epidemiologic study of 198 persons exposed for 3 months to drinking water disinfected with chlorine dioxide was conducted in a rural village. A control population of 118 nonexposed persons was also studied. Pre-exposure hematologic and serum chemical parameters were compared with test results after 115 days of exposure. Statistical analysis (ANOVA) of the data failed to identify any significant exposure-related effects. "

{Psychological problems related to chlorine dioxide exposure} "This paper discusses Minnesota Multiphasic Personality Inventory (MMPI) data obtained from individuals exposed to chlorine dioxide in the workplace who developed Multiple Chemical Sensitivity Syndrome."

(2004). Thyroid Function of Newborns and Exposure to Chlorine Dioxide By-products. Archives of Environmental Health: An International Journal: Vol. 59, No. 11, pp. 582-587.

(1986). Effects of chlorine dioxide on thyroid function in the African green monkey and the rat. Journal of Toxicology and Environmental Health: Vol. 19, No. 2, pp. 235-242.

(1990). Effects of chlorine dioxide on the developing rat brain. Journal of Toxicology and Environmental Health: Vol. 31, No. 1, pp. 29-44.

(1985). Effects of chlorine dioxide on thyroid function in neonatal rats. Journal of Toxicology and Environmental Health: Vol. 15, No. 2, pp. 315-322.

{Note: Some of the conclusions in this paper may not be reliable.} Includes IV treatment & oral doses

Available in the National Library of Australia collection. Author: Tentoni, Stuart C; Format: Book, Microform, Online; 10 p.

Preliminary data from a clinical trial involving more than 100 covid-19 patients in Ecuador has resulted in a claimed 100 cure rate within four days, according to Andreas Kalcker who is closely following the results of the effort. The tests were carried out by the Asociacion Ecuatoriana de Medicos Expertos en Medicina Integrativa, a group […]

On the Internet we find as much information as misinformation. One of the things they say is: If chlorine dioxide is eliminated by reacting with an acid, sho...

Varias publicaciones y videos compartidos en redes sociales aseguran que el nuevo coronavirus puede ser curado con dióxido de cloro, una sustancia que resulta de mezclar clorito de sodio, agua y ácido cítrico, y que es comercializada con el nombre de Solución Mineral Milagrosa (MMS por sus siglas en inglés). Sin embargo, no hay pruebas científicas que demuestren esto. Autoridades sanitarias de varios países y expertos consultados por AFP Factual alertan que su consumo con fines médicos puede ser perjudicial para la salud.

This is only the second case of sodium chlorite intoxication reported in the medical literature and the first to report the use of renal replacement therapy in combination with red cell exchange in its management.

Sodium chlorite is an inorganic by-product of chlorine dioxide formed during the chlorination of drinking water. Relatively little is known about the adverse health effects of exposure to sodium chlorite in drinking water. In this study, we evaluated sodium chlorite's immunomodulatory properties usi …

The increasing concern over the possibility of adverse health effects due to the chlorination of drinking water has led to a search for alternative methods of disinfection. One potential alternative is chlorine dioxide which, when used, gives rise to the end product chlorite. This study investigated …

False “bleach cures” have been touted for autism, cancer — and now Covid-19.

The Miracle Mineral Supplement, short MMS, is popular with a certain subculture of conventional medicine critics in Estonia, and has been a hotly debated subject in the media for some time. The Health Board has now taken the step to entirely ban the distribution of the supposed wonder drug.

Determination of the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID 19 - Full Text View.

FDA Adverse Event Reporting System (FAERS) Quarterly Data Extract Files

FDA is issuing warning letters to firms for selling fraudulent products with claims to prevent, treat, mitigate, diagnose or cure coronavirus disease 2019 (COVID-19).