Body--Effects on

A high-pressure release of a cylinder containing chlorine dioxide "Three contractors were injured in the blast, he said, two of whom were taken to the hospital for treatment with a combination of cuts and burn injuries from the chemicals"

**** (13 incidents 1984-2021}

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****!!!!*** {Collection of extensive safety data} "Vacated 1989 OSHA PEL TWA 0.1 ppm (0.3 mg/cu m); STEL 0.3 ppm (0.9 mg/cu m) is still enforced in some states."

{Extensive data, studies, dosages}

(2017) "administration of up to 40 ppm UC-1 to mice for 90 days is nontoxic"

Alcide is now used as a liquid sterilizer in an ultrasonic cleaner. It is excellent for herpes, fungus of the fingernail, warts and treatment of burn infection. The active ingredients (AI's) in this ...

(1987)

"This study was carried out in order to assess the effects of disinfectant-treatment on antioxidant response of Cyprinus carpio L. Therefore, enzymatic activities of glutathione S-transferases, glyoxalase I, glyoxalase II, glutathione peroxidases, glutathione reductase, catalase and total glutathione content of carp liver, exposed to surface water treated with three disinfectants for potabilization, sodium hypochlorite, chlorine dioxide and peracetic acid were investigated. " "[Need to verify whether this included effects of chlorine dioxide] chlorine compounds induced marked biochemical variations of carp liver"

"A single-dose oral toxicity study in rats... LD50 was calculated to be 290mg/kg" ".LD50 for intravenous administration was calculated to be 33.3 mg/kg" "LD50 for intraperitoneal administration was calculated to be 87.7 mg/kg" "A single dose acute dermal toxicity study in rats was conducted by exposing shaved skin...none of the animals showed any signs of systemic toxic effect or local irritation. The author concluded that the LD50 for dermal application is higher than 50 mg/kg."

****!!!****!!!!!*** 2001 {Tests on rats} "The acute toxicity and build-up toxicity of mice were tested by Horn's method and accumulation coefficient method, and the acute toxicity and accumulation toxicity of mice were studied through 90-day feeding tests on rats Subchronic toxicity of ClO2 and its by-products ClO-2 and ClO-3 mixed aqueous solutions, including weight gain, food utilization, hematological indicators, serum biochemical indicators, statistical analysis of liver (kidney) /weight ratio variance, and pathological histology microscopy of liver (kidney). The results showed that the ClO2 aqueous solution of 2 76.5mg/l, the NaClO2 and NaClO3 aqueous solution of 2 0 mg/l and the mixed aqueous solution with a total concentration of 553mg/lClO2 were all actual non-toxic aqueous solutions. 2 76.5mg/l ClO2, 2 0 0mg/l NaClO2 and NaClO3 aqueous solutions are also aqueous solutions without significant build-up; ClO2 mixture had no significant effect on weight gain and food utilization in rats (p 0 .0 5); There was no effect on rat hematological indicators such as white blood cell count (WBC) and hemoglobin (Hb) (p 0 .0 5); Tests of glutat-propylene transaminase (ALT), total protein (TP), albumin (ALB) and globulin (GLO) showed no significant difference between the control group and the high-dose group (p 0 .0 5); The liver-to-body ratio (%) and renal ratio (%) of rats in each test group and control group were analyzed by variance, and there was no significant difference between the groups (p 0 .0 5); Pathological histological examination results showed that no lesions were seen in the liver and kidney tissues of the test groups and control groups."

{in Chinese database} "This study studied the embryonic toxicity of sodium chlorate to wista rats through three generations of poisoning experiments. The results showed that sodium chlorate of 30, 120 and 360 mg/L had no effect on the visceral and bone development of the mice and did not show teratogenic use. The target value of the maximum contamination level of sodium chlorate in drinking water can be calculated by the experimental results, MCLG is calculated to be 1.1mg/L."

*****!!!!*** {Some statements may need more checking} "Using citric acid as an activator can cause intestinal acidosis with diarrhea, malaise, citrobacter (a bacterium that feeds on citrate) in sensitive people. This mixture is no longer used although it works, 4% HCL is better (if there is only a stronger concentration, it is lowered with distilled water until obtaining 4%). Note: Citric acid can be used to make CDS, since it does not enter the final mixture" "Do not use rubber droppers, as they do not have enough resistance to the alkaline pH 13 of sodium chlorite and over time, the rubber can dissolve in the liquid, leaving particles in the solution. These are also unsuitable for droppers since the drops dispensed are way too large." "People taking Warfarin should reduce the dose by measuring their coagulation values ​​as CDS improves blood viscosity as well."

{Chlorine dioxide effects on Mesenchymal Stem Cells }

"Eleven healthy volunteers were exposed to 0 (clean air), 0.5 and 2.2 ppm for 2hours"

**** "These observations are of much clinical significance in view of the retention of these products' active agent, i.e. 90 %) may effectively exert its essential microbicidal, anti-periodontal and oral malodour-neutralising actions."

"Alcide Allay® gel"

1985 "Sodium chlorite and lactic acid, the active ingredients "

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{Respiration dynamics, atmospheric pressure, etc}

"...the modulation of liver cytochrome P450-linked monooxygenases (MFO) and the genotoxic effects in erythrocytes of Cyprinus carpio fish exposed in situ to surface drinking water in the presence of ...chlorine dioxide (ClO2) ...were investigated in winter and summer." " In contrast, ClO2 generated the most notable inactivation, the CYP2E1-supported hydroxylation of p-nitrophenol being decreased up to 71% after 10 days’ treatment."

Groups of up to 13 pregnant rats were individually caged. Body weight, food and water consumption were recorded at days 1, 8, 15 and 22 of gestation and the dams were treated on days 8-15 with sodium chlorite, 0.1%, 0.5% or 2% in drinking water or by ...

"no clear evidence of a carcinogenic potential of sodium chlorite in B6C3F1mice."