Treatments included injection and topical treatments) "sharp surgical debridement was performed to remove the grossly necrotic tissue, if present. A wet dressing was applied once a day using 0.9 % saline-soaked gauze. Thereby, Oxoferin was used, which represents a 5-fold diluted WF10 solution used for topical wound treatment"

****!!!!****!!!**** {301 pages} "Given the small percentage of viable spores that remained in the low humidity studies, increasing either the concentration of ClO2 or the exposure time could result in successful sterilization under these conditions" "Unlike ethylene oxide, sterilization with ClO2 can be achieved at ambient temperature and pressure. When at the same relative humidity and temperature (30°C), ClO2 is 1075 times more efficient" **** "results from the cytotoxicity experiments suggest that post-sterilization processing for materials sterilized with ClO2 is warranted. [to minimize residuals, etc]" "bacterial adhesion is the first step towards the development of infection" "[pg 245] possibilities explaining the difference in bacterial adhesion... including differences in the physicochemical properties of the material and the more rapid development of an accumulating substratum of bacteria (nonviable) on the surface" "the presence of proteins adsorbed to the material did not affect the bactericidal activity of the ClO2 produced by the material" "suggests... the influence of fibronectin, not necessarily on promoting bacterial adhesion, but maintaining it" "the presence of proteins adsorbed to the material did not affect the bactericidal activity of the ClO2" "presence of albumin and fibronectin did impact the viability of bacteria" "coating, such as a hydrogel (Changez et al. 2004) or a thin polymer film (Kwok et al. 1999a), could be used to control the release of ClO2 from the material, thereby extending the duration of bactericidal activity" "An alternative... would be the development of a delivery system that is activated by ultrasound" "a molecule that was affording it protection... While initial studies suggested that the molecule was extracellular, further investigation determined that it was not." "oxidization of GSH may serve as a protective mechanism for other more vital cell components" "An alternative hypothesis for the mechanism of resistance is that SP030724 is over expressing a transmembrane molecule that is either inactivating or inhibiting the bactericidal effects of ClO2." "Calculating ClO2 generator parameters"

***!!!*** "In order to prevent biofilm formation and improve sanitation prescribed was the use of stabilized liquid chlorine dioxide (ClO2) in the 4‰ concentration for so-called night "shock" treatments, and 2‰ concentration for prophylactic daily disinfection of drinking water. With the improvement of the flocks’ health status, the "shock" treatments with ClO2 were repeated in the upcoming months. As an add-on therapy, 40 mg per bird of vitamin C through drinking water for three days was prescribed. The use of non-resorptive antibiotics, AD3E vitamins and amino acid supplements was excluded because they had failed to improve the flocks’ health status in the acute phase. ...on the use of stabilized liquid ClO2 in the water supply system of the laying flocks affected by severe colisepticemia resulted in radical decrease of mortality during the next three months."

{Note: This treatment is for theoretical uses. Validations of effectiveness and safety for various uses are needed. Negative effects HAVE been experienced by some people ingesting chlorine dioxide or injecting intravenously} "pharmaceutical composition for systemic, particularly parenteral treatment of infectious diseases, based on an aqueous, sterile and pyrogen-free solution of chlorine dioxide, which contains 5 to 1000 mg/l (ppm) dissolved chlorine dioxide (CI02) and preferably 3 to 10 g/l of an ionic tonicity regulator, optionally in combination with a non-ionic tonicity regulator. The composition additionally preferably contains a pH regulator, particularly a pH buffer system, adjusted to pH 7.3-7.5, and can furthermore contain DMSO or MSM. In the ready-to-use state, the composition is free of chlorate ions, hydrochloric acid and gaseous chlorine, or contains said components in a concentration of 1 mg/L (1 ppm) at maximum each.

{List of health conditions for which some people have speculated chlorine dioxide could be helpful}

****!!!!!**** {Discussion of *speculative* theories that need verification}