Treatments included injection and topical treatments) "sharp surgical debridement was performed to remove the grossly necrotic tissue, if present. A wet dressing was applied once a day using 0.9 % saline-soaked gauze. Thereby, Oxoferin was used, which represents a 5-fold diluted WF10 solution used for topical wound treatment"

****!!!!****!!!**** {301 pages} "Given the small percentage of viable spores that remained in the low humidity studies, increasing either the concentration of ClO2 or the exposure time could result in successful sterilization under these conditions" "Unlike ethylene oxide, sterilization with ClO2 can be achieved at ambient temperature and pressure. When at the same relative humidity and temperature (30°C), ClO2 is 1075 times more efficient" **** "results from the cytotoxicity experiments suggest that post-sterilization processing for materials sterilized with ClO2 is warranted. [to minimize residuals, etc]" "bacterial adhesion is the first step towards the development of infection" "[pg 245] possibilities explaining the difference in bacterial adhesion... including differences in the physicochemical properties of the material and the more rapid development of an accumulating substratum of bacteria (nonviable) on the surface" "the presence of proteins adsorbed to the material did not affect the bactericidal activity of the ClO2 produced by the material" "suggests... the influence of fibronectin, not necessarily on promoting bacterial adhesion, but maintaining it" "the presence of proteins adsorbed to the material did not affect the bactericidal activity of the ClO2" "presence of albumin and fibronectin did impact the viability of bacteria" "coating, such as a hydrogel (Changez et al. 2004) or a thin polymer film (Kwok et al. 1999a), could be used to control the release of ClO2 from the material, thereby extending the duration of bactericidal activity" "An alternative... would be the development of a delivery system that is activated by ultrasound" "a molecule that was affording it protection... While initial studies suggested that the molecule was extracellular, further investigation determined that it was not." "oxidization of GSH may serve as a protective mechanism for other more vital cell components" "An alternative hypothesis for the mechanism of resistance is that SP030724 is over expressing a transmembrane molecule that is either inactivating or inhibiting the bactericidal effects of ClO2." "Calculating ClO2 generator parameters"

The oral administration of chlorate salts reduces "the numbers of Gram-negative pathogens in gastrointestinal tracts of live food animals." "these data indicate that broilers rapidly convert chlorate residues to an innocuous metabolite, chloride ion, and that chlorate residues in excreta remain fairly high during the time around slaughter. Because the target tissue of chlorate is the lower gastrointestinal tract, the relatively high distribution of parent chlorate to inedible gastrointestinal tissues and low distribution to edible tissues is favorable for the biological activity and for food safety considerations."

"Composition is formed by adding a chlorine dioxide liberating compound with a weak organic acid and a heat activated saccharide." "The reaction of heat-sterilized CPD or ACD and sodium chlorite maximally liberates chlorine dioxide and minimizes the toxic effect of sodium chlorite on blood cells or blood components. The resulting solution can effectively inactivate viruses, ... can eliminate small inocula of bacteria, yeast or fungi from growing in a blood fraction, such as platelets during storage." "No adverse effects were noted when Factor VIII and Factor IX activities were measured, nor were any changes noted in hemoglobin or red blood cell survival. Accordingly, in vitro treatment according to the inventive process of baboon whole blood resulted in no detectable toxic effects." "Moreover, ****while sodium chlorite is known to have an adverse effect on blood cell integrity and functionality, blood factors or platelet viability are not significantly affected by treatment with sodium chlorite using [these specific patented] inventive compositions and processes.**** It is believed this is because the chlorite is converted by the inventive composition and process to chlorine dioxide, which is better tolerated by the cells."

Tetrachlorodecaoxide Systematic (IUPAC) name Molecular oxygen tetrachlorite hydrate Identifiers CAS number 92047-76-2 ATC. "WF 10 [Immunokine™, Macrokine™] is a 1 : 10 dilution of tetrachlorodecaoxide (TCDO) formulated for intravenous injection."

****!!!!******** "While a wide range of oral sodium chlorite regi-mens have been used, the most popular are between 0.75 and 1.5 mg/kg given over 2 – 7 days in a row, followed by a rest period of 7 – 16 days, then repeat-ing (17,25,26). Importantly, it has never been shown that oral sodium chlorite can be absorbed at levels that affect human macrophage function. In rats given radiolabeled chlorite, 34% of the initial dose can be found excreted in the urine over the next 72 h (27). However, in monkeys, chlorite is neutralized in saliva within 1 min and by gastric fl uid in vivo in 5 min (28). Keuhne, one of the world ’ s experts on WF10, states that he studied oral WF10 and found that it “ can act on these mechanisms only intravenously, not orally ” (29). Furthermore, there are data that raise concerns about the safety of oral sodium chlo-rite. According to McGrath and Keuhne, sodium chlorite is converted under acidic conditions (such as those in the stomach) to chlorine dioxide, which can be poisonous (12,29). While a small, short- duration study failed to show evidence of oral chlo-rite toxicity in humans (30), Keuhne stopped his research on oral WF10 “ after two patients collapsed and one nearly died ” while taking it (29)"

****!!!!****!!!!**** "deteriorating eyesight that may occur when using high doses of MMS for more than a few days." "Antioxidant deficiency is common with chronic diseases and advancing age. High intake or prolonged use of MMS will make this situation worse. Therefore it is important to increase antioxidant intake when using MMS. However, oxidants and antioxidants should be separated during the day or they may neutralize each other." "Because chlorine dioxide reacts especially well with vitamin C, it is advisable to take 1 gram or more when on a high dose of MMS for more than a few days to protect oxidation-sensitive structures, such as heart, brain and eyes." ******"technical sodium chlorite flakes containing 20% sodium chloride, while the MMS from StrideintoHealth (www.strideintohealth.com) is a pure sodium chlorite solution as used in the food industry. Nominally MMS is a 28% solution of the flakes but because of its high sodium chloride content the effective concentration of sodium chlorite is ****!!!!*** 22.4% which is the same in both products."

***!!!!*** {IV injections} "chlorine dioxide is less than 35 DEG C and can not decomposes. Chlorine dioxide is soluble in water, and dissolubility is 5 times of chlorine, divides pressure at room temperature 30mm/Hg, and dissolubility is 2.9g/L; At room temperature 760mm/Hg pressure (normal pressure), dissolubility is 3.1g/L. Chlorine dioxide is not easily hydrolyzed, and exists, at low concentrations (below 10mg/L) in water with monomolecular formation" "In theory, chlorine dioxide should be the anhydride of chlorous acid and chloric acid, i.e. 2ClO 2+ H 2o=HClO 2+ HClO 3 but, under actual water treatment condition, when pH value is 6 ~ 8, chlorine dioxide but has larger stability in water, and its concentration Absorbable organic halogens is at more than 48h" "[at least when generated and stored using some specific methods,] 1980ppm can be made, preserve under lucifuge sealing room temperature 25 DEG C of normal pressures, it is 1760ppm that 15 days ClO 2 solutions measure concentration, the concentration measuring chlorine dioxide for 3 months is 1285ppm" "chlorine dioxide belongs to monomolecular substance, can infiltrate the cell interior [destroy?] the virus and work.The cell of human normal, its cell membrane has the character of semipermeable membrane, chlorine dioxide can not infiltrate... The factor that need consider, chlorine dioxide degraded main component is ClO if having noxious substance to generate 2 -, [it needs to be confirmed to be?] harmless. If only considering to produce virus suppresses, in blood, chlorine dioxide concentration has 0.25ppm." *******"As the medicine of injection purposes, the adverse side effect that also will consider medicine to the body fluid balance of human body, blood pH, plasma carbon dioxide combining power, toxic and side effects, nerve centre to factors such as the sensitivitys of chlorine dioxide, carbon dioxide, whether medication suitable, can work, may occur."

****!!!!!**** {Discussion of *speculative* theories that need verification}

Dec 2020. The Army Military School (El rector de la universidad militar del Ejército , EMI) announced yesterday that it will "certify" the production of chlorine dioxide from any company . Rector of the EMI, Colonel Iván Omonte (Tel: (591) 4-4521844, dirpostgradocbba@adm.emi.edu.bo ). "The guest was Dr. Patricia Callisperis, who was one of the promoters." "Dr. Elizabeth Sánchez (EMI) affirmed chlorine dioxide "does not generate carcinogens or adverse reactions.""

***** {+591 (4) 644 3208} or https://posgrado.usfx.bo/posgrado/contactos.php ""Chlorine dioxide used at a concentration of 3000 ppm in the study group" "the evidence found in the study group of patients with mild symptoms that chlorine dioxide has no antiviral effect, nor does it have a statistically significant effect on increasing oxygen saturation." Regarding adverse reactions, the study indicates that "headache, dizziness and nausea, mild and transient" were recorded, but it clarifies that they are "manifestations of the disease".