President of the Senate, Eva Copa, appointed 4 people from COBOSOL (Bolivian organization) committee: Dr Helmunt Lema, Ms. Karla Rebollo, Wofgang Vargas & Guery Cordero.

{CAUTION: Does not include references for verifying safety or effectiveness} {Includes CDS protocol dosages for COVID-19 uses}

Discussion of Andreas Kalcker's work.

Tetrachlorodecaoxide Systematic (IUPAC) name Molecular oxygen tetrachlorite hydrate Identifiers CAS number 92047-76-2 ATC. "WF 10 [Immunokine™, Macrokine™] is a 1 : 10 dilution of tetrachlorodecaoxide (TCDO) formulated for intravenous injection."

Method of treating hyperglycemia induced Red Blood Cell Disease/Dysfunction (RBCD) caused by generation of early and late glycation end products. Method of treating hemolytic anemia, smoldering hemolytic anemia, sickle cell anemia, hemorrhagic diseases, hemorrhagic stroke, hemorrhagic bleeding. Method of treating RBCD to prevent progression to diabetes associated vascular complications referred to as Syndrome X, particularly to prevent progression to chronic kidney disease, coronary vascular disease, and peripheral vascular disease.

****!!!!******** "While a wide range of oral sodium chlorite regi-mens have been used, the most popular are between 0.75 and 1.5 mg/kg given over 2 – 7 days in a row, followed by a rest period of 7 – 16 days, then repeat-ing (17,25,26). Importantly, it has never been shown that oral sodium chlorite can be absorbed at levels that affect human macrophage function. In rats given radiolabeled chlorite, 34% of the initial dose can be found excreted in the urine over the next 72 h (27). However, in monkeys, chlorite is neutralized in saliva within 1 min and by gastric fl uid in vivo in 5 min (28). Keuhne, one of the world ’ s experts on WF10, states that he studied oral WF10 and found that it “ can act on these mechanisms only intravenously, not orally ” (29). Furthermore, there are data that raise concerns about the safety of oral sodium chlo-rite. According to McGrath and Keuhne, sodium chlorite is converted under acidic conditions (such as those in the stomach) to chlorine dioxide, which can be poisonous (12,29). While a small, short- duration study failed to show evidence of oral chlo-rite toxicity in humans (30), Keuhne stopped his research on oral WF10 “ after two patients collapsed and one nearly died ” while taking it (29)"

including Tetrachlorodecaoxide (TCDO) and WF10. "This study demonstrated that WF10 at a dose of 0.5 ml/kg was associated with a sustained immunological response, i.e., sustained elevation of CD8+ T cell numbers, consistent with the proposed mechanism of action. Furthermore, a single-center, phase I/II study, was conducted in 1997 to evaluate safety and the effects of WF10" "After interaction with heme proteins, the chlorite matrix of WF10 acquires oxidizing and chlorinating properties. It has been suggested that WF10 exerts potent immunomodulatory effects most likely through generating physiologic oxidative compounds namely chloramines. Chloramines have been reported to exert cell-protective and anti-inflammatory activities. [0082] Pro-oxidative substances can also have a direct effect on transcriptional activities of the NFAT species of transcription factors."

"Treating a macrophage related disease comprising administering to a subject in need thereof an effective amount of an oxidative agent or an immunosuppressive agent. The present invention also provides a method of modulating macrophage accumulation or activation comprising administering to a subject in need thereof an effective amount of an oxidative agent or an immunosuppressive agent. The oxidative agent can be chlorite or a chlorite containing..."

"The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation." "WF10, which comprises chlorite (e.g., in the form of tetrachlorodecaoxygen (TCDO)) as its active ingredient"

****!!!!****!!!!**** "deteriorating eyesight that may occur when using high doses of MMS for more than a few days." "Antioxidant deficiency is common with chronic diseases and advancing age. High intake or prolonged use of MMS will make this situation worse. Therefore it is important to increase antioxidant intake when using MMS. However, oxidants and antioxidants should be separated during the day or they may neutralize each other." "Because chlorine dioxide reacts especially well with vitamin C, it is advisable to take 1 gram or more when on a high dose of MMS for more than a few days to protect oxidation-sensitive structures, such as heart, brain and eyes." ******"technical sodium chlorite flakes containing 20% sodium chloride, while the MMS from StrideintoHealth (www.strideintohealth.com) is a pure sodium chlorite solution as used in the food industry. Nominally MMS is a 28% solution of the flakes but because of its high sodium chloride content the effective concentration of sodium chlorite is ****!!!!*** 22.4% which is the same in both products."

***!!!!*** {IV injections} "chlorine dioxide is less than 35 DEG C and can not decomposes. Chlorine dioxide is soluble in water, and dissolubility is 5 times of chlorine, divides pressure at room temperature 30mm/Hg, and dissolubility is 2.9g/L; At room temperature 760mm/Hg pressure (normal pressure), dissolubility is 3.1g/L. Chlorine dioxide is not easily hydrolyzed, and exists, at low concentrations (below 10mg/L) in water with monomolecular formation" "In theory, chlorine dioxide should be the anhydride of chlorous acid and chloric acid, i.e. 2ClO 2+ H 2o=HClO 2+ HClO 3 but, under actual water treatment condition, when pH value is 6 ~ 8, chlorine dioxide but has larger stability in water, and its concentration Absorbable organic halogens is at more than 48h" "[at least when generated and stored using some specific methods,] 1980ppm can be made, preserve under lucifuge sealing room temperature 25 DEG C of normal pressures, it is 1760ppm that 15 days ClO 2 solutions measure concentration, the concentration measuring chlorine dioxide for 3 months is 1285ppm" "chlorine dioxide belongs to monomolecular substance, can infiltrate the cell interior [destroy?] the virus and work.The cell of human normal, its cell membrane has the character of semipermeable membrane, chlorine dioxide can not infiltrate... The factor that need consider, chlorine dioxide degraded main component is ClO if having noxious substance to generate 2 -, [it needs to be confirmed to be?] harmless. If only considering to produce virus suppresses, in blood, chlorine dioxide concentration has 0.25ppm." *******"As the medicine of injection purposes, the adverse side effect that also will consider medicine to the body fluid balance of human body, blood pH, plasma carbon dioxide combining power, toxic and side effects, nerve centre to factors such as the sensitivitys of chlorine dioxide, carbon dioxide, whether medication suitable, can work, may occur."

***!!!!****"WF10 is an infusion therapy currently approved only in Thailand under the name ****IMMUNOKINE for the treatment of post-radiation-therapy syndromes and adjunctive therapy of diabetic foot ulcers." "Company believes that the results are not sufficient to justify the further development of WF10 for the treatment of allergic rhinitis and plans to discontinue all WF10 development. " "Crescita Therapeutics Inc. (Crescita), will own the Company's existing drug development business"

Hugo Arando Zambrana, director of the Chemistry Career at the Tomás Frías Autonomous University (UATF) {Chem Dept phone (591) 2 6223280}, died of COVID-19, reported Omar Veliz (Ramos?), head of this entity. He had been in charge of producing chlorine dioxide on behalf of the Government.

****!!!!!**** {Discussion of *speculative* theories that need verification}

Dec 2020. The Army Military School (El rector de la universidad militar del Ejército , EMI) announced yesterday that it will "certify" the production of chlorine dioxide from any company . Rector of the EMI, Colonel Iván Omonte (Tel: (591) 4-4521844, dirpostgradocbba@adm.emi.edu.bo ). "The guest was Dr. Patricia Callisperis, who was one of the promoters." "Dr. Elizabeth Sánchez (EMI) affirmed chlorine dioxide "does not generate carcinogens or adverse reactions.""

July 2020 "Immunologist Roger Carvajal, who advises the Ministry of Health, maintains that the substance is harmful. Dr Fernando Liendo, who chairs the Alcos group, and Dr. Patricia Callisperis, who heads a commission of specialists that travels through Bolivia, uses it in patients for COVID-19." " Immunologist Roger Carvajal, a member of el Comité Científico COVID-19, said "People are asking people for the Scientific Committee to do the research. " "The epidemiologist doctor Juan José Villena, of the Departmental Health Service (SEDES) of Tarija, recognized "good results" in five patients with coronavirus." "The Bolivian Online Doctors Network (la Red de Médicos Bolivianos en Línea) warned that the product not only does not cure the virus, but could be harmful."

****!!!*****!!!!**** "According to Jim Humble’s MMS recipe, after adding citric acid or acetic acid to sodium chlorite during the 3 minutes, a small amount of chlorine dioxide is formed, but the majority (at least 90%) is not transformed at all. According to Jim Humble the chorine dioxide forming process continues inside the body –but this is questionable... the swallowed sodium chlorite will be absorbed in the stomach and can thus become toxic." [Actually, other studies may have showed swallowed chlorine dioxide may distribute through some parts of the body] "Even swallowed chorine dioxide cannot get into the blood stream and reach other parts of the body because it is consumed up by reactive amino acids already in the stomach. Onthe contrary, MMS is applied internally, and the sodium chlorite ingredient of MMS is absorbed in the stomach, and can reach all organs of the body via the bloodstream." "chlorine dioxide penetrates tissues like a front, where it can be found only behind the moving reaction front and not in the tissues ahead. Sodium chlorite reacts much slower; therefore it practically enters the tissue without any reaction and becomes 'systemic'." "(per Jim Humble) 5% acetic acid or the citric acid in lime or lemon"

IV amt is given w/non-acidic, 99.999% pure chlorine dioxide. "CDS (for drinking) is reaction of sodium chlorite and 4% hydrochloric acid." "LD50 is 292 mg/kg for 14 days. We use 10 mg or mL in a liter of water. The difference is overwhelming."

{Includes DisQus contact info} "Our study shows that ClO2 could be a safe and viable way of treating and mitigating the effects of avian coronavirus infections, and raises the possibility that similar effects could be observed in other organisms."

***** {+591 (4) 644 3208} or https://posgrado.usfx.bo/posgrado/contactos.php ""Chlorine dioxide used at a concentration of 3000 ppm in the study group" "the evidence found in the study group of patients with mild symptoms that chlorine dioxide has no antiviral effect, nor does it have a statistically significant effect on increasing oxygen saturation." Regarding adverse reactions, the study indicates that "headache, dizziness and nausea, mild and transient" were recorded, but it clarifies that they are "manifestations of the disease".