{Mucor sp is one of the types of fungi that can cause horse hoof wall separation.} White line disease " is restricted to the inner-most area of the stratum medium. This area has a moisture content of 75 percent in a normal hoof. " "This potent disinfectant used on a properly prepared hoof eliminated the presence of fungal spores. I have had positive results using this chemical on thrush, canker, scratches and rainrot. Chlorine dioxide at 20,000 ppm is activated using 1 deciliter chlorine dioxide, 1 deciliter of vinegar with 4 liters of water for a safe effective method of treating fungal infections of the horse’s hoof."

"most crucial step was to neutralize any active infection. This was done with Grand Circuit’s White Lightning, a chlorine dioxide in an aqueous base (water). One cup of White Lightning is mixed with an equal portion of acetic acid (white vinegar) and further diluted with 1 gallon of water to make the soaking solution" "Chlorine dioxide works by dissolving the biofilms (protective layer surrounding organisms), then it alters the pH, which thereby neutralizes the organism itself. It is effective against fungi and bacteria, so it immediately destroys thrush. It also is a treatment for canker, white line disease and other hoof ailments. When the infection is highly advanced, you can often smell it, much like thrush. White Lightning breaks down the hydrogen-sulfur bond, which is where the putrid smell comes from. Do not be surprised if after the first soak the smell dissipates."

White Lightning chlorine dioxide treatment for horses for hoof thrush, skin fungus and white line disease.

****!!!!*** [Taiko] "chlorine dioxide, which can cure an intractable skin disease, such as skin disease caused by humanpapilloma virus, against which no effective therapeutic method had been developed" "sodium dihydrogenphosphate as the pH adjuster whose pH is 2.5 to 6.8 as a 5% aqueous solution at 25°C, ****remarkably enhances**** the preservation stability of the chlorine dioxide solution"

"There is disclosed a method for treating dermatologic diseases caused by microbial overgrowth or inflammation, such as psoriasis, fungal infections, eczema, dandruff, acne, genital herpes lesions, and leg ulcers. There is further disclosed an antiviral lubricating composition that is effective in preventing the transmission of the HIV virus and other sexually transmitted diseases. There is also disclosed systemic anti-inflammatory compositions and formulations and a method for reducing tissue inflammation in tissues such as the bowel, muscle, bone, tendon and joints (e.g. arthritis)."

****!!!!**** {Related to Alcide chlorine dioxide product} "Methods for preventing and treating microbial wound infections, especially of peritoneal cavity wounds including those having indwelling catheters, and enhancing wound repair while minimizing adhesions and scar formation involve the infusion or irrigation of the wound with a solution containing a pharmacologically acceptable carrier and chlorine dioxide in an amount ranging from about 5 ppm to 1000 ppm, and having a chlorine dioxide to chlorite ratio of at least 5:1. Typical solutions contain chlorine dioxide in isotonic saline and exhibit a pH of from about 5 to about 7.5. Sodium chlorite is employed in preferred embodiments." "formation of scarring and/or fibrous adhesions. An additional feature of ClO2 and related oxychlorine systems is their capability to inhibit the stimulation of fibroplasia, the proliferation of fibroblast cells and expression of collagen, which ordinarily ensues following wounding. As shown in the examples that follow, the oxychlorines resulting from acidification of chlorite to form chlorous acid significantly inhibits fibroblast proliferation and collagen formation." "A further study confirming the effect of ClO2 on wound healing set out in greater particularity below combines an investigation of the immediate cellular response (chemotaxis) of the body to injury using isolated polymorphonuclear leukocytes, and another investigation assessing the interaction of ClO2 with free radicals which form during the course of tissue repair collagen synthesis. In the former case, ClO2 was found to control chemotaxis by affecting the quality and morphology of the associated polymorphonuclear leukocytes. In the latter case, the ClO2, which is a stable free radical containing one unpaired electron, was found to neutralize the superoxide and related radicals involved in the process of collagen production." "solutions of 350 ppm in buffered saline have been shown to be safely infusable into cows' udders without stimulation of any immune response by the animals" "In contrast to antibiotics, systemic absorption of the compositions of the invention is minimized in treatments using them because of the inorganic nature of chlorine dioxide, and its reductive degradation to chloride as a result of its interaction with organic matter (including bacteria, fungi, and viruses). It is important to note that materials may be non-inflammatory (i.e., not provoke inflammation) but not anti-inflammatory (i.e., counter the effects of inflammation). Chlorine dioxide has been found to be non-inflammatory, by virtue of being infusible into the peritoneal cavity and other body cavities without evoking the inflammatory response, as well as being anti-inflammatory; see the copending U.S. application Ser. No. 08/133,465, filed Oct. 8, 1993, and parent case U.S. Pat. No. 5,252,343, cited and incorporated by reference above. In order to utilize the germ-killing and non-inflammatory qualities of chlorine dioxide, it is preferable to isolate it from chlorites and its acidic form, chlorous acid" " the lactate so formed may enhance angiogenesis, collagen synthesis and deposition, and modulate the response of fibroblasts to growth factors in the wound ...In embodiments where these effects are not desired, organic acids other than lactic acid are employed." "ability of the chlorine dioxide solutions to bring about a marked reduction in Staphylococcus epidermidis biofilms" "The 50 ppm ClO2 solution, on the other hand, is well tolerated by mammalian tissue, as, for example, when used as an eye irrigant, to treat bacterial infections induced in rabbits, to infuse into a cow's udder, or as a uterine douche for mares and cows in the prevention and treatment of endometritis." "a chlorine dioxide concentration of about 7.5 ppm inhibits free radical formation by 74% and at a concentration of 15 ppm, by 100%." "If the solution is prepared in the presence of a phosphate buffer which immediately neutralizes the lactic acid, the formation of chlorine dioxide is inhibited in the system. The solution has no inhibitory effect with rat fetal lung fibroblasts. Thus, it is not chlorite ion that is operative, but ClO2."

***!!!!*** {Includes photos of wound healing} "Three surgical case reports are presented to demonstrate the clinical efficacy of using an improved aqueous solution of chlorine dioxide complex (160 ppm) as a topical antiseptic in the post operative management of serious wounds in dogs"

"Keratosis pilaris (KP) is a skin condition in which white bumps appear" "New unproven treatments include topical chlorine dioxide complex wash,"

" Sodium chlorite generates chlorine dioxide which is very effective in killing Gram+ and Gram- bacteria, yeasts and fungi, subsequently breaking down into the components of natural tears – salt, water and oxygen."

"Preferably, the liquid medium has sufficient chlorine dioxide precursor so as to have a potential of producing chlorine dioxide in the range of about 0.002 % to about 3% by weight, based on the total weight of the liquid medium including the chlorine dioxide precursor or precursors." "A series of solutions was prepared using different concentrations of a stabilized chlorine dioxide product, sold by Bio-cide International, Inc. under the trademark Purogene. The stabilized chlorine dioxide product included 2.0% by weight of potential (ultimate yield) chlorine dioxide and 0.085% by weight of sodium carbonate."

"1 ppm Purite™=1 ppm stabilized chlorine dioxide 1 ppm Purite™=1.25 ppm chlorite ion 1 ppm Purite™=1.6761 ppm sodium chlorite 1 ppm Purite™=2.1216 ppm technical grade* sodium chlorite Technical grade sodium chlorite contains about 80% NaCIO2, 13% NaCl, 5% Na2 CO3 and 2% NaClO3." "Preferably, there is present from about 0.01 % (w/v) to about 0.05% (w/v), and even more preferably about 0.015% (w/v) to about 0.03% (w/v) stabilized chlorine dioxide present in the solution."

2010 {in Chinese} "Chlorine dioxide slow release gel has a broad-spectrum antibacterial effect, and is satisfied with the therapeutic effect modeled on the back trauma of rabbits. "

"Chlorine dioxide aids inrelieving pain after wisdom tooth removal and enhancesthe healing process following oral surgical procedures .According to a study... chlorine dioxide is capable of completely killing Enterobacter faecalis within 30 minutes at higher concentrations, making chlorine dioxide an effective endodontic irrigant." "The delayed healing in the Penetrater chlorine dioxide oral gel group may be due to a loweramount of collagen in the wound tissue and to the lower number of myofibroblasts, which play a crucial role in woundcontraction" "The amounts of protein in wounds treated with Aftamed gel or Intrasite gel were significantly increased compared with the amount in the chlorine dioxide gel-treated group."

{Similar to TCDO} "daily moist-wound-treatment (MWT) with polyacrylate hydrogel with (group I) or without (group II) pharmaceutical sodium chlorite (DAC N-055)."

Local tetrachlorodecaoxygen anion complex (TCDO) had three therapeutic effects in difficult wounds, substantiated on day 14 in a multicentre double-bl…

Master Mineral Solution Testimonials: Disinfectant Success stories. Videos and Writings. MMS was discovered by Jim Humble in 1996 to be an effective solution for Malaria, and since that time according to user reports; much more.

"a 1:10 dilution of a MECA spray (metastabilized chlorous acid/chlorine dioxide), twice weekly for 3–4 weeks using about 8 ounces per rabbit at each application"

Rabbits with ringworm can be treated "with a dilution of a metastabilized chlorous acid-chlorine dioxide compound applied as either a dip or a spray".

Ringworm can be treated

" non-toxic, non-mutagenic and totally harmless to normal healthy tissue. In addition, our ClO2 based products all possess strong anti-inflammatory properties via oxidation of free radicals and elimination of harmful cytokines (chemicals that the body releases in response to a wound or infection). Deactivation of these molecules reduces pain, irritation and scarring." "DentA-ClO2 – Dental Paste: Reduces and helps eliminate the bacteria responsible for periodontitis and gingivitis (which causes bad breath) in dogs and cats. Whitens teeth. Derma-ClO2: Wound Healing Ointment: Promotes healing and prevents scarring from hot spots, scratches, rain rot and fungal or bacterial infection of the skin on all animals. Epi-ClO2 - Shampoo - Non-toxic, non-irritating antiseptic shampoo immediately cleans and deodorizes hair and skin. Soothing emollients relieve irritation and soften hair coat. Eliminates skunk odor. Oti-ClO2 – Ear Cleansing Solution: Gentle, non-toxic ear-cleaning agent formulated to maintain healthy ears in dogs and cats. Treats inflammation (otitis) of the external ear. Podi-ClO2 Green – Antimicrobial Gel: Preventive gel for hoof treatment that eliminates thrush, white line disease, hoof canker, abscesses and other infectious conditions. Podi-ClO2 Liquid – Antimicrobial Liquid: Hoof treatment that eliminates thrush, white line disease, hoof canker, abscesses and other infectious conditions

A method for treating nail fungus by soaking the infected nail(s) in a dilute solution of chlorine dioxide in water. "using a solution of chlorine dioxide in water containing a minimum of 80 parts per million chlorine dioxide as the treating agent."

"Chlorine dioxide products that are the ideal solutions for an extensive list of animal health-related applications, including but not limited to: * Treatment of fungal and yeast infections, including ringworm * Antiseptic shampoo cleans and deodorizes hair coat and skin, eliminates dandruff and skunk odors * Bacterial dermatitis and dermatological "hot spots" in animals * Gingivitis and periodontal disease, ear fungus and bacterial diseases. Some products can be sprayed or fogged for environmental cleaning."

A chlorine dioxide-containing gel was compared with 3 commercially available antimicrobials and 1 antibiotic intended for topical use. This gel was tested at 0.5 X and 4 X and was found to be more effective as a 4 X gel in treating Pseudomonas aeruginosa-infected excised wounds on mice. To further c …

Three surgical case reports are presented to demonstrate the clinical efficacy of using an improved aqueous solution of chlorine dioxide complex ******(160 ppm) as a topical antiseptic in the post operative management of serious wounds in dogs.

{Includes Alcide chlorine dioxide} "The repair processes of incised wounds depend, in part, on fibroplasia induced by soluble mediators from monocytic macrophages. Two topical antimicrobials were evaluated, each of which effectively controlled wound sepsis and yet each had widely different effects on fibroplasia and wound strength." "Alcide-treated wounds incorporated less than 50% of the amount of 14C-proline than did the wounds treated with C31G. However, Alcide-treated wounds epithelialized as rapidly as did control wounds, and had minimal scar formation. Microscopic evaluations indicated greatly reduced inflammatory infiltrates in Alcide-treated wounds, indicating that reduced wound strength may be associated with lack of fibroblast-stimulating activity by monocytes. "

A new animal antiseptic and disinfectant : Chlorine Dioxide Complex developed by Frontier Pharmaceutical Inc. This versatile biocide manages wounds, topical infections, deep and traumatic wounds, chronic skin and ear infections of bacterial, fungal, viral and protozoan origin

Both drugs are efficacious. Tetrachlorodecaoxide yields healthy granulation tissue earlier. Both drugs appear to be safe for application.