{Includes Alcide chlorine dioxide} "The repair processes of incised wounds depend, in part, on fibroplasia induced by soluble mediators from monocytic macrophages. Two topical antimicrobials were evaluated, each of which effectively controlled wound sepsis and yet each had widely different effects on fibroplasia and wound strength." "Alcide-treated wounds incorporated less than 50% of the amount of 14C-proline than did the wounds treated with C31G. However, Alcide-treated wounds epithelialized as rapidly as did control wounds, and had minimal scar formation. Microscopic evaluations indicated greatly reduced inflammatory infiltrates in Alcide-treated wounds, indicating that reduced wound strength may be associated with lack of fibroblast-stimulating activity by monocytes. "

A new animal antiseptic and disinfectant : Chlorine Dioxide Complex developed by Frontier Pharmaceutical Inc. This versatile biocide manages wounds, topical infections, deep and traumatic wounds, chronic skin and ear infections of bacterial, fungal, viral and protozoan origin

Both drugs are efficacious. Tetrachlorodecaoxide yields healthy granulation tissue earlier. Both drugs appear to be safe for application.

(2008 originally published) Chlorine dioxide oxidizes and neutralizes free radicals and cytokines. Ingredients in some of Frontier's 20 CD products include catalysts that cause CD to release immediately, wetting agents, etc. Use high concentrations for: removing scars, tooth whitening, horse hoof fungal thrush, nail fungus (400 ppm). Fairly high: wart removal (200 ppm)--[Comment: Could possibly get FDA approval by listing salicylic acid as the active ingredient, & then also including sodium chlorite and lactic acid activator??] (****Includes urea as a wetting agent to help get into skin****). Medium: itchy scalp fungus. Low concentrations: gynegel against STDs (not FDA approved at that time), acne. Other uses: kill yeast in dogs' ears, canker sores, pet shampoo, exfoliant for women's faces, skin protectant including glycerin for men's hands (callouses, scratches), topical that removes pain of sunburn by oxidizing free radicals & cytokines; vaginal disinfectant, cosmesis, sinus flush that quickly relieves rhino colds and acts more slowly on flu; mouth rinse. Toothpaste kills bacteria faster & oxidizes their sulfur compounds & odors, treats periodontal disease, removes biofilm, & whitens enamel. *****!!!**** Treats Raynaud's Syndrome by opening up blood vessels in hands. Did some testing of intravenous injection of monkey for HIV, but dosed too high so killed too much of red blood cells." "When *chlorine* oxidizes organic compounds, it adds a chlorine atom, making the compound carcinogenic and irritating. Chlorine dioxide doesn't."

"29 patients underwent local treatment with TCDO (Oxoferin) while Beta-isodona was used in 31 cases." "Oxoferin induces a development of granulation tissue on exposed tendons, bones, and fasciae and the granular tissue is of much better quality than after treatment with Betaisodona. Concerning its effect on the degree of contamination, Oxoferin proved to be at least as efficacious as the established and effective antiseptic Betaisodona. Both substances are tolerated well and the application is simple"

NaClO2 was found to have the best balance of high antibacterial toxicity with low ocular toxicity.

The tentatively lower rate of relapses and the acceleration of wound closure in a subgroup of patients with parasite persistence warrant future studies on the activity of DAC N-055. sodium chlorite

Diluted form of chlorite-based WF10 (Tetrachlorodecaoxide/TCDO)

****{May categorically be considered usable as a "medical treatment"?, in addition to as "topical treatment". --Uncertain whether received approval for organic production. Apparently has been approved at a minimum as "topical" treatment in general production.}

Chlorine dioxide hoof bath treatment for digital dermatitis ( hairy heel warts), the most common infectious cause of lameness in dairy cattle

Horse hoof treatment

{Note: "Activated" sodium chlorite (chlorine dioxide) has also been shown to be safe and effective at appropriate doses for topically treating wounds}

Silkworm disease management: chlorine dioxide (500 ppm) in slaked lime (0.5%) solution was found 100% effective against silkworm pathogens viz., the spores of Nosema bombycis and Bacillus thuringiensis, nuclear polyhedra of BmNPV and conidia of Beauveria bassiana. The disinfectant tested, at laboratory and farmers' level, was found effective in disinfection of rearing house, appliances and against egg surface contamination. The disinfectant did not have adverse effect on silkworm growth, health and economic characters.

MMS can be absorb by the skin and delivered directly into underlying muscle. According to Jim Humble, using MMS orally provides the active ingredient - Chlorine

.The use of activated MMS when further diluted in water on the skin could be beneficial in many cases. It could help many skin disorder, burns, wounds and scars

****!!!!**** "In case of clinically diagnosed wound infections, topical wound disinfection was allowed for 5 consecutive days with saline containing 970 ppm chlorine dioxide... wound cleansing and disinfection with gauzes soaked in physiological saline solution containing 320 ppm chlorine dioxide... for 15 minutes... In CL endemic regions with poor infrastructure, bipolar HF-EC is a robust technology to debride CL lesions under local anaesthesia. The combination with DAC N-055 MWT provides additional anti-parasitic, antimicrobial and wound healing effects."

****!!!!****!!!** "There is disclosed a method for treating dermatologic diseases caused by microbial overgrowth or inflammation, such as psoriasis, fungal infections, eczema, dandruff, acne, genital herpes lesions, and leg ulcers. There is further disclosed an antiviral lubricating composition that is effective in preventing the transmission of the HIV virus and other sexually transmitted diseases. There is also disclosed systemic anti-inflammatory compositions and formulations and a method for reducing tissue inflammation in tissues such as the bowel, muscle, bone, tendon and joints (e.g., arthritis)." "composition which comprises a chlorine dioxide liberating compound and a protic acid." " Systemic formulations that are administered orally, or by injection into muscles, joint capsules, peritoneum, intralymphatically or directly into inflamed tissue." "The inhibition of PMN influx into a wound site can simultaneously reduce the formation of malondialdehyde and conjugated dienes, suggesting that most of the free radicals generated during the early stage of wound healing are mediated by PMNs"

{Wound treatment} {Graphs include decrease in chlorine dioxide (ClO2) as a function of time in a protein-rich environment, log reduction of pathogens (including biofilm), etc}

.The use of activated MMS when further diluted in water on the skin could be beneficial in many cases. It could help many skin disorder, burns, wounds and scars

3 treatments in dogs, & in vitro

Says contains 120 ppm stable chlorine dioxide. Management of the underlying disease such a flea bite dermatitis, diabetes, tumor, etc must also accompany treatment of the topical infection with Ciderm Topical Antiseptic. If used in conjunction with other topical medications such as a steroids or antibiotics do not use Ciderm Topical Antiseptic Solution at the same time. Wait at least 10 mins after applying the Ciderm SP before applying other topical agents to avoid oxidation of the other medication.

Contains 160 ppm chlorine dioxide

WuzaWart contains DioxiCare, Frontier's proprietary Chlorine Dioxide Complex. Chlorine dioxide along with glycerin quickly penetrate the wart tissue and attack the papilloma virus which causes the wart. This virus is anaerobic (wants to avoid ...

FutureCow offers the only Teat Scrubber that utilizes the best cleaning solution option, Chlorine Dioxide, in the teat cleaning process.

Allow acidified sodium chlorite teat dip

{ClorDiSys} Killed pinworms collected from mice. Relative humidity ranged from 52% to 67%, and temperatures ranged from 23 to 26 °C. Chlorine dioxide gas was delivered to the chamber until a concentration of 1 mg/L (360 ppm) was reached. The exposure periods were calculated by multiplying the desired ppm by the exposure period in hours.

We have invented a simple technique to produce high purity chlorine dioxide solutions and proved that ClO2 is a size selective antimicrobial agent. Its dilute solutions are not harmful for humans but can kill microbes within millisecons. In addition bacteria are not able to...

Background and Purpose. This study aimed to evaluate the wound healing activities of Aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats. Experimental Approach. Forty-eight Sprague Dawley rats were chosen for this study, divided ...