ClO2-containing oxychlorine solutions could be an innovative strategy for the suppression of surgical adhesion formation, with the additional advantage of contributing antiseptic properties.

"The device comprises an optional backing layer; a chlorine dioxide source layer comprising chlorine dioxide or chlorine dioxide-generating components, and oxy-chlorine anions; and a barrier layer interposed between the chlorine dioxide source layer and the tissue, wherein the barrier layer substantially ***prohibits passage therethrough of the oxy-chlorine anions and permits passage therethrough of the substantially oxy-chlorine anion free chlorine dioxide*** composition" " In certain embodiments, the chlorine dioxide concentration ranges... most preferably from about 30 to about 200 ppm chlorine dioxide..."

"Provided in the present invention is a method for initiating the proliferation, migration and differentiation of stem cells in mammals, comprising the following steps: preparing a stem cell initiation agent containing chlorine dioxide and administering the stem cell initiation agent to target tissues of mammals, wherein an effective amount of chlorine dioxide is provided when administering the stem cell initiation agent to the target tissues of mammals. Also provided in the present invention is the use of chlorine dioxide in the preparation of a drug for initiating the proliferation, migration and differentiation of stem cells. The method of the present invention has a broad application range, and is suitable for various requirements of treating diseases using the tissue regeneration ability and immunity regulation ability of stem cells or prompting the initiation of the proliferation, migration and differentiation of stem cells in injured organs and organisms having regenerated tissues; furthermore, using the method of the present invention, the proliferation, migration and differentiation of stem cells can be initiated quickly and moderately; and the method has few side effects or no side effects, and can continuously be used for initiating the proliferation, migration and differentiation of stem cells." "The chlorine dioxide-containing stem cell promoter of the present invention can be administered by any route which can reach the intended tissue, for example, by intravenous drip, intravenous injection, intraarterial injection, intramuscular injection, subcutaneous injection, Intradermal, intracardiac, intraperitoneal, intrathecal, intraarticular, puncture, rectal, sublingual, nasal, transdermal, inhalation or topical administration to damaged organs or Organization, etc., "

***!!! The present invention relates to a cell apoptosis inducer containing chlorine dioxide. The present invention relates to a cell apoptosis inducer kit containing the following two independent components: the first component: a chlorine dioxide precursor solid, or a solution containing a chlorine dioxide precursor; and the second component: an auqeous solution of an acidity pH adjuster; the two components are stored separately, and can be mixed before use so that in-situ reaction occurs and the cell apoptosis inducer containing chlorine dioxide is prepared; and the amounts and concentrations of the first component and the second component enable the pH of the mixed solution to be 1.5-6.5. The present invention further relates to use of the cell apoptosis inducer containing chlorine dioxide or the cell apoptosis inducer kit containing chlorine dioxide in preparing drugs for treating tumors, or use thereof in preparing anti-aging drugs for target tissues of mammals, or use thereof as cosmetics, or use thereof in preparing chemotherapeutic drugs. "the apoptosis inducing agent comprises chlorine dioxide dissolved in water, wherein the concentration of chlorine dioxide is from 500 to 2900 ppm, based on mass." VThe data showed that after 30 hours, untreated cells showed 15% spontaneous apoptosis. However, 80% of cells treated with the chlorine dioxide formulation showed cell death. Specifically, in Cama-1 cells, chlorine dioxide-induced apoptosis was started 9 hours after the addition of 500 ppm of chlorine dioxide preparation, and after 30 hours of treatment, the apoptotic cells reached 80%. Other conditions were the same, but the 500 ppm chlorine dioxide preparation was adjusted to a pH of 3.0 by a pH adjuster, and only over 45% of the cells showed death, indicating that the acidic environment contributes to an increase in cancer cell apoptosis."

"There is disclosed a method for treating dermatologic diseases caused by microbial overgrowth or inflammation, such as psoriasis, fungal infections, eczema, dandruff, acne, genital herpes lesions, and leg ulcers. There is further disclosed an antiviral lubricating composition that is effective in preventing the transmission of the HIV virus and other sexually transmitted diseases. There is also disclosed systemic anti-inflammatory compositions and formulations and a method for reducing tissue inflammation in tissues such as the bowel, muscle, bone, tendon and joints (e.g. arthritis)."

****!!!!**** {Related to Alcide chlorine dioxide product} "Methods for preventing and treating microbial wound infections, especially of peritoneal cavity wounds including those having indwelling catheters, and enhancing wound repair while minimizing adhesions and scar formation involve the infusion or irrigation of the wound with a solution containing a pharmacologically acceptable carrier and chlorine dioxide in an amount ranging from about 5 ppm to 1000 ppm, and having a chlorine dioxide to chlorite ratio of at least 5:1. Typical solutions contain chlorine dioxide in isotonic saline and exhibit a pH of from about 5 to about 7.5. Sodium chlorite is employed in preferred embodiments." "formation of scarring and/or fibrous adhesions. An additional feature of ClO2 and related oxychlorine systems is their capability to inhibit the stimulation of fibroplasia, the proliferation of fibroblast cells and expression of collagen, which ordinarily ensues following wounding. As shown in the examples that follow, the oxychlorines resulting from acidification of chlorite to form chlorous acid significantly inhibits fibroblast proliferation and collagen formation." "A further study confirming the effect of ClO2 on wound healing set out in greater particularity below combines an investigation of the immediate cellular response (chemotaxis) of the body to injury using isolated polymorphonuclear leukocytes, and another investigation assessing the interaction of ClO2 with free radicals which form during the course of tissue repair collagen synthesis. In the former case, ClO2 was found to control chemotaxis by affecting the quality and morphology of the associated polymorphonuclear leukocytes. In the latter case, the ClO2, which is a stable free radical containing one unpaired electron, was found to neutralize the superoxide and related radicals involved in the process of collagen production." "solutions of 350 ppm in buffered saline have been shown to be safely infusable into cows' udders without stimulation of any immune response by the animals" "In contrast to antibiotics, systemic absorption of the compositions of the invention is minimized in treatments using them because of the inorganic nature of chlorine dioxide, and its reductive degradation to chloride as a result of its interaction with organic matter (including bacteria, fungi, and viruses). It is important to note that materials may be non-inflammatory (i.e., not provoke inflammation) but not anti-inflammatory (i.e., counter the effects of inflammation). Chlorine dioxide has been found to be non-inflammatory, by virtue of being infusible into the peritoneal cavity and other body cavities without evoking the inflammatory response, as well as being anti-inflammatory; see the copending U.S. application Ser. No. 08/133,465, filed Oct. 8, 1993, and parent case U.S. Pat. No. 5,252,343, cited and incorporated by reference above. In order to utilize the germ-killing and non-inflammatory qualities of chlorine dioxide, it is preferable to isolate it from chlorites and its acidic form, chlorous acid" " the lactate so formed may enhance angiogenesis, collagen synthesis and deposition, and modulate the response of fibroblasts to growth factors in the wound ...In embodiments where these effects are not desired, organic acids other than lactic acid are employed." "ability of the chlorine dioxide solutions to bring about a marked reduction in Staphylococcus epidermidis biofilms" "The 50 ppm ClO2 solution, on the other hand, is well tolerated by mammalian tissue, as, for example, when used as an eye irrigant, to treat bacterial infections induced in rabbits, to infuse into a cow's udder, or as a uterine douche for mares and cows in the prevention and treatment of endometritis." "a chlorine dioxide concentration of about 7.5 ppm inhibits free radical formation by 74% and at a concentration of 15 ppm, by 100%." "If the solution is prepared in the presence of a phosphate buffer which immediately neutralizes the lactic acid, the formation of chlorine dioxide is inhibited in the system. The solution has no inhibitory effect with rat fetal lung fibroblasts. Thus, it is not chlorite ion that is operative, but ClO2."

***!!!!*** {Includes photos of wound healing} "Three surgical case reports are presented to demonstrate the clinical efficacy of using an improved aqueous solution of chlorine dioxide complex (160 ppm) as a topical antiseptic in the post operative management of serious wounds in dogs"

" Sodium chlorite generates chlorine dioxide which is very effective in killing Gram+ and Gram- bacteria, yeasts and fungi, subsequently breaking down into the components of natural tears – salt, water and oxygen."

"Preferably, the liquid medium has sufficient chlorine dioxide precursor so as to have a potential of producing chlorine dioxide in the range of about 0.002 % to about 3% by weight, based on the total weight of the liquid medium including the chlorine dioxide precursor or precursors." "A series of solutions was prepared using different concentrations of a stabilized chlorine dioxide product, sold by Bio-cide International, Inc. under the trademark Purogene. The stabilized chlorine dioxide product included 2.0% by weight of potential (ultimate yield) chlorine dioxide and 0.085% by weight of sodium carbonate."

"1 ppm Purite™=1 ppm stabilized chlorine dioxide 1 ppm Purite™=1.25 ppm chlorite ion 1 ppm Purite™=1.6761 ppm sodium chlorite 1 ppm Purite™=2.1216 ppm technical grade* sodium chlorite Technical grade sodium chlorite contains about 80% NaCIO2, 13% NaCl, 5% Na2 CO3 and 2% NaClO3." "Preferably, there is present from about 0.01 % (w/v) to about 0.05% (w/v), and even more preferably about 0.015% (w/v) to about 0.03% (w/v) stabilized chlorine dioxide present in the solution."

{Note: "Activated" sodium chlorite (chlorine dioxide) has also been shown to be safe and effective at appropriate doses for topically treating wounds}

"29 patients underwent local treatment with TCDO (Oxoferin) while Beta-isodona was used in 31 cases." "Oxoferin induces a development of granulation tissue on exposed tendons, bones, and fasciae and the granular tissue is of much better quality than after treatment with Betaisodona. Concerning its effect on the degree of contamination, Oxoferin proved to be at least as efficacious as the established and effective antiseptic Betaisodona. Both substances are tolerated well and the application is simple"

A method for treating nail fungus by soaking the infected nail(s) in a dilute solution of chlorine dioxide in water. "using a solution of chlorine dioxide in water containing a minimum of 80 parts per million chlorine dioxide as the treating agent."

"Chlorine dioxide products that are the ideal solutions for an extensive list of animal health-related applications, including but not limited to: * Treatment of fungal and yeast infections, including ringworm * Antiseptic shampoo cleans and deodorizes hair coat and skin, eliminates dandruff and skunk odors * Bacterial dermatitis and dermatological "hot spots" in animals * Gingivitis and periodontal disease, ear fungus and bacterial diseases. Some products can be sprayed or fogged for environmental cleaning."

(2008 originally published) Chlorine dioxide oxidizes and neutralizes free radicals and cytokines. Ingredients in some of Frontier's 20 CD products include catalysts that cause CD to release immediately, wetting agents, etc. Use high concentrations for: removing scars, tooth whitening, horse hoof fungal thrush, nail fungus (400 ppm). Fairly high: wart removal (200 ppm)--[Comment: Could possibly get FDA approval by listing salicylic acid as the active ingredient, & then also including sodium chlorite and lactic acid activator??] (****Includes urea as a wetting agent to help get into skin****). Medium: itchy scalp fungus. Low concentrations: gynegel against STDs (not FDA approved at that time), acne. Other uses: kill yeast in dogs' ears, canker sores, pet shampoo, exfoliant for women's faces, skin protectant including glycerin for men's hands (callouses, scratches), topical that removes pain of sunburn by oxidizing free radicals & cytokines; vaginal disinfectant, cosmesis, sinus flush that quickly relieves rhino colds and acts more slowly on flu; mouth rinse. Toothpaste kills bacteria faster & oxidizes their sulfur compounds & odors, treats periodontal disease, removes biofilm, & whitens enamel. *****!!!**** Treats Raynaud's Syndrome by opening up blood vessels in hands. Did some testing of intravenous injection of monkey for HIV, but dosed too high so killed too much of red blood cells." "When *chlorine* oxidizes organic compounds, it adds a chlorine atom, making the compound carcinogenic and irritating. Chlorine dioxide doesn't."

******!!!!********* "inhaling high concentration ClO2 gases for an extended time can be dangerous for human health because the alveolar membrane is extremely thin (a mere 1-2 microns and in some places even below 1 micron). The effect of ClO2 in these membranes is somewhat counterbalanced, however, by the intense blood circulation there." "O2 can remove biofilms swiftly [12] because it is highly soluble in water and unlike ozone it does not react with the extracellular polysaccharides of the biofilm. This way ClO2 can penetrate into biofilms rapidly to reach and kill the microbes living within the film."

Says contains 120 ppm stable chlorine dioxide. Management of the underlying disease such a flea bite dermatitis, diabetes, tumor, etc must also accompany treatment of the topical infection with Ciderm Topical Antiseptic. If used in conjunction with other topical medications such as a steroids or antibiotics do not use Ciderm Topical Antiseptic Solution at the same time. Wait at least 10 mins after applying the Ciderm SP before applying other topical agents to avoid oxidation of the other medication.

3 treatments in dogs, & in vitro

****{May categorically be considered usable as a "medical treatment"?, in addition to as "topical treatment". --Uncertain whether received approval for organic production. Apparently has been approved at a minimum as "topical" treatment in general production.}

{Includes Alcide chlorine dioxide} "The repair processes of incised wounds depend, in part, on fibroplasia induced by soluble mediators from monocytic macrophages. Two topical antimicrobials were evaluated, each of which effectively controlled wound sepsis and yet each had widely different effects on fibroplasia and wound strength." "Alcide-treated wounds incorporated less than 50% of the amount of 14C-proline than did the wounds treated with C31G. However, Alcide-treated wounds epithelialized as rapidly as did control wounds, and had minimal scar formation. Microscopic evaluations indicated greatly reduced inflammatory infiltrates in Alcide-treated wounds, indicating that reduced wound strength may be associated with lack of fibroblast-stimulating activity by monocytes. "