"Provided in the present invention is a method for initiating the proliferation, migration and differentiation of stem cells in mammals, comprising the following steps: preparing a stem cell initiation agent containing chlorine dioxide and administering the stem cell initiation agent to target tissues of mammals, wherein an effective amount of chlorine dioxide is provided when administering the stem cell initiation agent to the target tissues of mammals. Also provided in the present invention is the use of chlorine dioxide in the preparation of a drug for initiating the proliferation, migration and differentiation of stem cells. The method of the present invention has a broad application range, and is suitable for various requirements of treating diseases using the tissue regeneration ability and immunity regulation ability of stem cells or prompting the initiation of the proliferation, migration and differentiation of stem cells in injured organs and organisms having regenerated tissues; furthermore, using the method of the present invention, the proliferation, migration and differentiation of stem cells can be initiated quickly and moderately; and the method has few side effects or no side effects, and can continuously be used for initiating the proliferation, migration and differentiation of stem cells." "The chlorine dioxide-containing stem cell promoter of the present invention can be administered by any route which can reach the intended tissue, for example, by intravenous drip, intravenous injection, intraarterial injection, intramuscular injection, subcutaneous injection, Intradermal, intracardiac, intraperitoneal, intrathecal, intraarticular, puncture, rectal, sublingual, nasal, transdermal, inhalation or topical administration to damaged organs or Organization, etc., "

***!!! The present invention relates to a cell apoptosis inducer containing chlorine dioxide. The present invention relates to a cell apoptosis inducer kit containing the following two independent components: the first component: a chlorine dioxide precursor solid, or a solution containing a chlorine dioxide precursor; and the second component: an auqeous solution of an acidity pH adjuster; the two components are stored separately, and can be mixed before use so that in-situ reaction occurs and the cell apoptosis inducer containing chlorine dioxide is prepared; and the amounts and concentrations of the first component and the second component enable the pH of the mixed solution to be 1.5-6.5. The present invention further relates to use of the cell apoptosis inducer containing chlorine dioxide or the cell apoptosis inducer kit containing chlorine dioxide in preparing drugs for treating tumors, or use thereof in preparing anti-aging drugs for target tissues of mammals, or use thereof as cosmetics, or use thereof in preparing chemotherapeutic drugs. "the apoptosis inducing agent comprises chlorine dioxide dissolved in water, wherein the concentration of chlorine dioxide is from 500 to 2900 ppm, based on mass." VThe data showed that after 30 hours, untreated cells showed 15% spontaneous apoptosis. However, 80% of cells treated with the chlorine dioxide formulation showed cell death. Specifically, in Cama-1 cells, chlorine dioxide-induced apoptosis was started 9 hours after the addition of 500 ppm of chlorine dioxide preparation, and after 30 hours of treatment, the apoptotic cells reached 80%. Other conditions were the same, but the 500 ppm chlorine dioxide preparation was adjusted to a pH of 3.0 by a pH adjuster, and only over 45% of the cells showed death, indicating that the acidic environment contributes to an increase in cancer cell apoptosis."

****!!!!**** {Related to Alcide chlorine dioxide product} "Methods for preventing and treating microbial wound infections, especially of peritoneal cavity wounds including those having indwelling catheters, and enhancing wound repair while minimizing adhesions and scar formation involve the infusion or irrigation of the wound with a solution containing a pharmacologically acceptable carrier and chlorine dioxide in an amount ranging from about 5 ppm to 1000 ppm, and having a chlorine dioxide to chlorite ratio of at least 5:1. Typical solutions contain chlorine dioxide in isotonic saline and exhibit a pH of from about 5 to about 7.5. Sodium chlorite is employed in preferred embodiments." "formation of scarring and/or fibrous adhesions. An additional feature of ClO2 and related oxychlorine systems is their capability to inhibit the stimulation of fibroplasia, the proliferation of fibroblast cells and expression of collagen, which ordinarily ensues following wounding. As shown in the examples that follow, the oxychlorines resulting from acidification of chlorite to form chlorous acid significantly inhibits fibroblast proliferation and collagen formation." "A further study confirming the effect of ClO2 on wound healing set out in greater particularity below combines an investigation of the immediate cellular response (chemotaxis) of the body to injury using isolated polymorphonuclear leukocytes, and another investigation assessing the interaction of ClO2 with free radicals which form during the course of tissue repair collagen synthesis. In the former case, ClO2 was found to control chemotaxis by affecting the quality and morphology of the associated polymorphonuclear leukocytes. In the latter case, the ClO2, which is a stable free radical containing one unpaired electron, was found to neutralize the superoxide and related radicals involved in the process of collagen production." "solutions of 350 ppm in buffered saline have been shown to be safely infusable into cows' udders without stimulation of any immune response by the animals" "In contrast to antibiotics, systemic absorption of the compositions of the invention is minimized in treatments using them because of the inorganic nature of chlorine dioxide, and its reductive degradation to chloride as a result of its interaction with organic matter (including bacteria, fungi, and viruses). It is important to note that materials may be non-inflammatory (i.e., not provoke inflammation) but not anti-inflammatory (i.e., counter the effects of inflammation). Chlorine dioxide has been found to be non-inflammatory, by virtue of being infusible into the peritoneal cavity and other body cavities without evoking the inflammatory response, as well as being anti-inflammatory; see the copending U.S. application Ser. No. 08/133,465, filed Oct. 8, 1993, and parent case U.S. Pat. No. 5,252,343, cited and incorporated by reference above. In order to utilize the germ-killing and non-inflammatory qualities of chlorine dioxide, it is preferable to isolate it from chlorites and its acidic form, chlorous acid" " the lactate so formed may enhance angiogenesis, collagen synthesis and deposition, and modulate the response of fibroblasts to growth factors in the wound ...In embodiments where these effects are not desired, organic acids other than lactic acid are employed." "ability of the chlorine dioxide solutions to bring about a marked reduction in Staphylococcus epidermidis biofilms" "The 50 ppm ClO2 solution, on the other hand, is well tolerated by mammalian tissue, as, for example, when used as an eye irrigant, to treat bacterial infections induced in rabbits, to infuse into a cow's udder, or as a uterine douche for mares and cows in the prevention and treatment of endometritis." "a chlorine dioxide concentration of about 7.5 ppm inhibits free radical formation by 74% and at a concentration of 15 ppm, by 100%." "If the solution is prepared in the presence of a phosphate buffer which immediately neutralizes the lactic acid, the formation of chlorine dioxide is inhibited in the system. The solution has no inhibitory effect with rat fetal lung fibroblasts. Thus, it is not chlorite ion that is operative, but ClO2."

***!!!!*** {Includes photos of wound healing} "Three surgical case reports are presented to demonstrate the clinical efficacy of using an improved aqueous solution of chlorine dioxide complex (160 ppm) as a topical antiseptic in the post operative management of serious wounds in dogs"

"Preferably, the liquid medium has sufficient chlorine dioxide precursor so as to have a potential of producing chlorine dioxide in the range of about 0.002 % to about 3% by weight, based on the total weight of the liquid medium including the chlorine dioxide precursor or precursors." "A series of solutions was prepared using different concentrations of a stabilized chlorine dioxide product, sold by Bio-cide International, Inc. under the trademark Purogene. The stabilized chlorine dioxide product included 2.0% by weight of potential (ultimate yield) chlorine dioxide and 0.085% by weight of sodium carbonate."

"1 ppm Purite™=1 ppm stabilized chlorine dioxide 1 ppm Purite™=1.25 ppm chlorite ion 1 ppm Purite™=1.6761 ppm sodium chlorite 1 ppm Purite™=2.1216 ppm technical grade* sodium chlorite Technical grade sodium chlorite contains about 80% NaCIO2, 13% NaCl, 5% Na2 CO3 and 2% NaClO3." "Preferably, there is present from about 0.01 % (w/v) to about 0.05% (w/v), and even more preferably about 0.015% (w/v) to about 0.03% (w/v) stabilized chlorine dioxide present in the solution."

A method for treating nail fungus by soaking the infected nail(s) in a dilute solution of chlorine dioxide in water. "using a solution of chlorine dioxide in water containing a minimum of 80 parts per million chlorine dioxide as the treating agent."