Oxine AH is a powerful weapon against fungal and bacterial infections of the hoof and lower leg – such as thrush, white line disease, and scratches – yet it doesn't harm living tissue whe…

ClO2-containing oxychlorine solutions could be an innovative strategy for the suppression of surgical adhesion formation, with the additional advantage of contributing antiseptic properties.

A chlorine dioxide liquid agent comprising dissolved chlorine dioxide gas as a constituent, which is used as a remedy for skin diseases and mucosal diseases to be applied to an infected area in order to improve symptoms of an infected area caused by infection with a pathogenic microorganism Infectious skin and mucous membrane diseases.

****!!!!**** "The chlorine dioxide solution contains dissolved chlorine dioxide gas as a constituent component." " sodium chlorite and potassium chlorite are preferred, and sodium chlorite is most preferred, not only for the reasons of easy availability, but also from the viewpoint of excellent sustainability of chlorine dioxide activity." "acne vulgaris... Chlorine dioxide concentration at the time of dilution: 150 ppm)" "chlorine dioxide liquid with a concentration of 10 ppm or more will inactivate adenoviruses that cause epidemic keratoconjunctivitis, and it is disclosed that the chlorine dioxide liquid does not affect the eyeball even at a concentration of 250 ppm." " By selecting sodium dihydrogen phosphate or a mixture of sodium dihydrogen phosphate and disodium hydrogen phosphate, and using it in combination with sodium chlorite, the storage stability is further improved" "In this way, unnecessary consumption of sodium chlorite is suppressed and sodium chlorite is effectively consumed, so the storage stability is further improved (prolonged), and the concentration of chlorine dioxide fluctuates over time (variation) during storage. ) Is further reduced (not only the decrease in concentration is suppressed, but the increase in concentration is also suppressed"

"also relates to compositions that are useful for topical application, especially to nails and adjacent tissue for the treatment of mycotic and microbial infections." "In additon to the treatment of microbial and mycotic infections, the antimicrobial compositions of the present invention also serve to rid the treatment area of cellular debris that accumulates as a result of the infection." "may further comprise... surfactants... used to stabilize the chlorine dioxide compound in an aqueous solution." "those with the worst nail condition at the beginning showed the highest percentage improvement over the four week period."

"Topically, the tetrachlorodecaoxygen anion complex (TCDO) has a therapeutic effect in wound healing [2, 9] with an increase of pO2 in the capillary blood [3] and systematically in experimental infections [1], It constitutes a negatively charged complex of chlorine and oxygen (Cl4O10)n, MWn=1 = 301.8. Incubation with hemoproteins leads to complex degradation and the appearance of oxygen water in chloride [4], whereby toxic oxygen species are not formed [8]. Heme-ac-tivated TCDO was described to be bactericidal for a number of microbial species [6, 7], to enhance phagocytosis by resident peritoneal macrophages of mice [7], and to stimulate humoral and cellular immunity [1]."

Werner, Sabine, and Richard Grose. Regulation of Wound Healing by Growth Factors and Cytokines. Physiol Rev 83: 835–870, 2003; 10.1152/physrev.00032.2002.—Cutaneous wound healing is a complex proce...

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The compositions of the present invention include a protic acid and a chlorite ion, and may further include other optional components such as a gelling agent, colorant and/or preservative. Methods disclosed herein include applying the composition to a surface of a bee-hive. Honey produced by bees administered a composition of this invention is also disclosed.

" in the case of skin or mucocutaneous diseases, the liquid composition of the present invention containing... preferably 10 to 250 ppm of chlorine dioxide, ... preferably 700 to 20000 ppm of sodium chlorite. Gauze, cotton or non-woven fabric is impregnated and applied to the affected area or inserted into the affected area 1 to 3 times a day for at least 5 minutes, preferably 10 minutes or more. In the case of instillation or nose dropping, the liquid composition of the present invention containing chlorine dioxide at a concentration of... preferably 10 to 250 ppm, may be used about 1 to 6 times a day." " sprayed into the air in the room to prevent viral diseases such as influenza virus, bacterial diseases and fungal diseases" "(4) The chlorine dioxide solution composition is soaked directly into the mask or eye patch, or a gauze or non-woven fabric soaked with the chlorine dioxide solution composition is attached to the mask or eye patch, so that viral diseases, bacterial diseases and Prevent fungal diseases."

"The topical composition includes the use of chlorine dioxide, chlorite salts, benzoyl peroxide, an alpha hydroxy acid, antifungal and antibiotic agents. Also provided is a heat-generating device for use in treating at least one nail infected with fungus and a toe sock device." "Heavily infected toes are piled high with fungus-laden keratin debris that prevents topical medications... from reaching all the infected tissue." "concentrations... of chlorine dioxide, more preferably 20-40 ppm" "Saturating conditions may be maintained by having a chemical generating system so that additional chlorine dioxide is being synthesized constantly or in response to loss of chlorine dioxide by leakage, decay or use during treatment." "For example 0.66% chlorite generates to a suitable chlorine dioxide concentration. For compositions where one wishes a 1% chlorite in chlorine dioxide composition, one may add 1.66% metal chlorite along with an acid or other suitable reagent to degrade some of the metal chlorite into chlorine dioxide. Benzoyl peroxide and similar compounds is also a preferred component of the present invention... 6-10% are more preferred particularly when used in conjunction with 1-3% metal chlorite and an antifungal and antibiotic." "While citric acid/citrate buffer is typically used, other pH-adjusting agents or buffering agents may be used"

{Includes: methods of obtaining high-purity chlorine dioxide; thickeners} "Also disclosed are methods of making and using a substantially non-cytotoxic thickened fluid compositions or solutions comprising chlorine dioxide solution. An oxidizing composition of reduced irritation is also disclosed." "Lower concentrations in the range of about 5 to about 500 ppm are useful when used in the mouth or near the nose so as to minimize exposure to the chlorine-like odor of a chlorine dioxide-containing composition. Higher concentrations in the range of about 20 to about 2000 ppm are useful when used in areas containing a substantial concentration of reactive organic material, such as wound fluid in wounds." "cytotoxicity results predominantly from the presence of oxy-chlorine anions. Accordingly,... no more than about 0.25 mg oxy-chlorine anion per gram" "To minimize soft tissue irritation by the chlorine dioxide containing composition, the substantially non-cytotoxic composition has a pH of at least about 3.5" "Substantially pure chlorine dioxide may be prepared by any known method, then bubbling a gas (e.g., air) through that solution (sparging) and into a second container of deionized water, to prepare the product solution of substantially pure chlorine dioxide. Only ClO2 and possibly some water vapor is transferred..." "200 ppm aqueous solution of chlorine dioxide. Sample 39 was prepared by diluting an about 600 ppm substantially pure chlorine dioxide solution"

"In an embodiment, the composition comprises about 1 to about 1000 ppm chlorine dioxide. In another embodiment, the composition comprises about 20 to about 400 ppm chlorine dioxide" "In some embodiments, the device comprises: an optional backing layer; a layer comprising the chlorine dioxide source; and a barrier layer interposed between the chlorine dioxide source layer and the tissue, wherein the barrier layer substantially prohibits passage therethrough of the oxy-chlorine anions and permits passage therethrough of the substantially oxy-chlorine anion free chlorine dioxide composition."

***!!!*** "The USEPA requires products making fungicidal claims to demonstrate disinfectant efficacy against Trychophyton mentagrophytes, also known as "T. ment". Trichophyton species are associated with public health related infections including ring worm and Athlete's Foot. Applied to tests as a spore, this fungi poses a formidable challenge for disinfectant products such that disinfectant products have an EPA stated maximum allowable contact time of 10 minutes to demonstrate total kill. The product tested in this study demonstrated total kill of the test microorganism at contact times of both 1 and 2 minutes."

"For the treatment of skin fungus (greased heels, girth itch, ringworm, minor abrasions, scratches, rain rot, etc)."

100 ppm chlorine dioxide

"Conventional treatments involve radical removal of affected hoof tissue resulting in hoof mutilation and usually transportation to a clinic; therefore, the goal of the study was to find a method of treatment that can be done in the field" "Ciderm EQ (sold under the Trade name White Lightning Gel)" "This treatment appears to be as or more effective than radical hoof mutilation" "Treatment for white line disease has usually involved radical hoof trimming in conjunction with some sort of topical antimicrobial therapy to reduce the incidence of secondary infections. Although these methods have seen variable success, they often result in secondary complications or a noticeable degree of loss of function... Chlorine dioxide gas, generated from a two-part gel, should be an effective antimicrobial agent in this circumstance due to its broad antibacterial and antifungal spectrum in addition to its ability to access small recesses that may harbor such organisms and be protected from other topical treatments." "Horses that started out with the highest lesion volumes also had the greatest percentage reduction in lesion volumes at the end of the 12 week study period. So it seems that even though different environments correlated with disease severity initially, the environment did not affect the response to therapy."

{Mucor sp is one of the types of fungi that can cause horse hoof wall separation.} White line disease " is restricted to the inner-most area of the stratum medium. This area has a moisture content of 75 percent in a normal hoof. " "This potent disinfectant used on a properly prepared hoof eliminated the presence of fungal spores. I have had positive results using this chemical on thrush, canker, scratches and rainrot. Chlorine dioxide at 20,000 ppm is activated using 1 deciliter chlorine dioxide, 1 deciliter of vinegar with 4 liters of water for a safe effective method of treating fungal infections of the horse’s hoof."

"most crucial step was to neutralize any active infection. This was done with Grand Circuit’s White Lightning, a chlorine dioxide in an aqueous base (water). One cup of White Lightning is mixed with an equal portion of acetic acid (white vinegar) and further diluted with 1 gallon of water to make the soaking solution" "Chlorine dioxide works by dissolving the biofilms (protective layer surrounding organisms), then it alters the pH, which thereby neutralizes the organism itself. It is effective against fungi and bacteria, so it immediately destroys thrush. It also is a treatment for canker, white line disease and other hoof ailments. When the infection is highly advanced, you can often smell it, much like thrush. White Lightning breaks down the hydrogen-sulfur bond, which is where the putrid smell comes from. Do not be surprised if after the first soak the smell dissipates."

White Lightning chlorine dioxide treatment for horses for hoof thrush, skin fungus and white line disease.

****!!!!*** [Taiko] "chlorine dioxide, which can cure an intractable skin disease, such as skin disease caused by humanpapilloma virus, against which no effective therapeutic method had been developed" "sodium dihydrogenphosphate as the pH adjuster whose pH is 2.5 to 6.8 as a 5% aqueous solution at 25°C, ****remarkably enhances**** the preservation stability of the chlorine dioxide solution"

****!!!!****{Doses & studies for skin (& maybe internal?) treatments} " treating fungal infections using a metal salt of chlorite alone or in combination with a conventional antifungal agent... topical or systemic."*****[? Statements need verification] "chlorite ions are many times less toxic than chlorine dioxide to animal cells and that maintaining it at a higher pH will allow for a higher concentrations to be used. Concentrations of up to 0.5% in internal fluids have been shown to be acceptable for internal use. Higher dosages are likely to be acceptable also. External use allows for considerably higher concentrations to be used, and even higher concentrations are acceptable for short-term contact." "A pattern observed indicates that sodium chlorite alone at a pH that does not create chlorine dioxide and in combination with conventional antifungal agents is a superior antifungal agent than the antifungal alone against 100% of fungi tested."

***!!!!*** {Includes photos of wound healing} "Three surgical case reports are presented to demonstrate the clinical efficacy of using an improved aqueous solution of chlorine dioxide complex (160 ppm) as a topical antiseptic in the post operative management of serious wounds in dogs"

" Sodium chlorite generates chlorine dioxide which is very effective in killing Gram+ and Gram- bacteria, yeasts and fungi, subsequently breaking down into the components of natural tears – salt, water and oxygen."

{Similar to TCDO} "daily moist-wound-treatment (MWT) with polyacrylate hydrogel with (group I) or without (group II) pharmaceutical sodium chlorite (DAC N-055)."

Master Mineral Solution Testimonials: Disinfectant Success stories. Videos and Writings. MMS was discovered by Jim Humble in 1996 to be an effective solution for Malaria, and since that time according to user reports; much more.

"a 1:10 dilution of a MECA spray (metastabilized chlorous acid/chlorine dioxide), twice weekly for 3–4 weeks using about 8 ounces per rabbit at each application"

A method for treating nail fungus by soaking the infected nail(s) in a dilute solution of chlorine dioxide in water. "using a solution of chlorine dioxide in water containing a minimum of 80 parts per million chlorine dioxide as the treating agent."