Oxine AH is a powerful weapon against fungal and bacterial infections of the hoof and lower leg – such as thrush, white line disease, and scratches – yet it doesn't harm living tissue whe…

****!!!!**** "The chlorine dioxide solution contains dissolved chlorine dioxide gas as a constituent component." " sodium chlorite and potassium chlorite are preferred, and sodium chlorite is most preferred, not only for the reasons of easy availability, but also from the viewpoint of excellent sustainability of chlorine dioxide activity." "acne vulgaris... Chlorine dioxide concentration at the time of dilution: 150 ppm)" "chlorine dioxide liquid with a concentration of 10 ppm or more will inactivate adenoviruses that cause epidemic keratoconjunctivitis, and it is disclosed that the chlorine dioxide liquid does not affect the eyeball even at a concentration of 250 ppm." " By selecting sodium dihydrogen phosphate or a mixture of sodium dihydrogen phosphate and disodium hydrogen phosphate, and using it in combination with sodium chlorite, the storage stability is further improved" "In this way, unnecessary consumption of sodium chlorite is suppressed and sodium chlorite is effectively consumed, so the storage stability is further improved (prolonged), and the concentration of chlorine dioxide fluctuates over time (variation) during storage. ) Is further reduced (not only the decrease in concentration is suppressed, but the increase in concentration is also suppressed"

" in the case of skin or mucocutaneous diseases, the liquid composition of the present invention containing... preferably 10 to 250 ppm of chlorine dioxide, ... preferably 700 to 20000 ppm of sodium chlorite. Gauze, cotton or non-woven fabric is impregnated and applied to the affected area or inserted into the affected area 1 to 3 times a day for at least 5 minutes, preferably 10 minutes or more. In the case of instillation or nose dropping, the liquid composition of the present invention containing chlorine dioxide at a concentration of... preferably 10 to 250 ppm, may be used about 1 to 6 times a day." " sprayed into the air in the room to prevent viral diseases such as influenza virus, bacterial diseases and fungal diseases" "(4) The chlorine dioxide solution composition is soaked directly into the mask or eye patch, or a gauze or non-woven fabric soaked with the chlorine dioxide solution composition is attached to the mask or eye patch, so that viral diseases, bacterial diseases and Prevent fungal diseases."

{Includes: methods of obtaining high-purity chlorine dioxide; thickeners} "Also disclosed are methods of making and using a substantially non-cytotoxic thickened fluid compositions or solutions comprising chlorine dioxide solution. An oxidizing composition of reduced irritation is also disclosed." "Lower concentrations in the range of about 5 to about 500 ppm are useful when used in the mouth or near the nose so as to minimize exposure to the chlorine-like odor of a chlorine dioxide-containing composition. Higher concentrations in the range of about 20 to about 2000 ppm are useful when used in areas containing a substantial concentration of reactive organic material, such as wound fluid in wounds." "cytotoxicity results predominantly from the presence of oxy-chlorine anions. Accordingly,... no more than about 0.25 mg oxy-chlorine anion per gram" "To minimize soft tissue irritation by the chlorine dioxide containing composition, the substantially non-cytotoxic composition has a pH of at least about 3.5" "Substantially pure chlorine dioxide may be prepared by any known method, then bubbling a gas (e.g., air) through that solution (sparging) and into a second container of deionized water, to prepare the product solution of substantially pure chlorine dioxide. Only ClO2 and possibly some water vapor is transferred..." "200 ppm aqueous solution of chlorine dioxide. Sample 39 was prepared by diluting an about 600 ppm substantially pure chlorine dioxide solution"

{Mucor sp is one of the types of fungi that can cause horse hoof wall separation.} White line disease " is restricted to the inner-most area of the stratum medium. This area has a moisture content of 75 percent in a normal hoof. " "This potent disinfectant used on a properly prepared hoof eliminated the presence of fungal spores. I have had positive results using this chemical on thrush, canker, scratches and rainrot. Chlorine dioxide at 20,000 ppm is activated using 1 deciliter chlorine dioxide, 1 deciliter of vinegar with 4 liters of water for a safe effective method of treating fungal infections of the horse’s hoof."

****!!!!*** [Taiko] "chlorine dioxide, which can cure an intractable skin disease, such as skin disease caused by humanpapilloma virus, against which no effective therapeutic method had been developed" "sodium dihydrogenphosphate as the pH adjuster whose pH is 2.5 to 6.8 as a 5% aqueous solution at 25°C, ****remarkably enhances**** the preservation stability of the chlorine dioxide solution"

****!!!!****{Doses & studies for skin (& maybe internal?) treatments} " treating fungal infections using a metal salt of chlorite alone or in combination with a conventional antifungal agent... topical or systemic."*****[? Statements need verification] "chlorite ions are many times less toxic than chlorine dioxide to animal cells and that maintaining it at a higher pH will allow for a higher concentrations to be used. Concentrations of up to 0.5% in internal fluids have been shown to be acceptable for internal use. Higher dosages are likely to be acceptable also. External use allows for considerably higher concentrations to be used, and even higher concentrations are acceptable for short-term contact." "A pattern observed indicates that sodium chlorite alone at a pH that does not create chlorine dioxide and in combination with conventional antifungal agents is a superior antifungal agent than the antifungal alone against 100% of fungi tested."

***!!!!*** {Includes photos of wound healing} "Three surgical case reports are presented to demonstrate the clinical efficacy of using an improved aqueous solution of chlorine dioxide complex (160 ppm) as a topical antiseptic in the post operative management of serious wounds in dogs"

A method for treating nail fungus by soaking the infected nail(s) in a dilute solution of chlorine dioxide in water. "using a solution of chlorine dioxide in water containing a minimum of 80 parts per million chlorine dioxide as the treating agent."

****!!!!**** "In case of clinically diagnosed wound infections, topical wound disinfection was allowed for 5 consecutive days with saline containing 970 ppm chlorine dioxide... wound cleansing and disinfection with gauzes soaked in physiological saline solution containing 320 ppm chlorine dioxide... for 15 minutes... In CL endemic regions with poor infrastructure, bipolar HF-EC is a robust technology to debride CL lesions under local anaesthesia. The combination with DAC N-055 MWT provides additional anti-parasitic, antimicrobial and wound healing effects."

****!!!!****!!!** "There is disclosed a method for treating dermatologic diseases caused by microbial overgrowth or inflammation, such as psoriasis, fungal infections, eczema, dandruff, acne, genital herpes lesions, and leg ulcers. There is further disclosed an antiviral lubricating composition that is effective in preventing the transmission of the HIV virus and other sexually transmitted diseases. There is also disclosed systemic anti-inflammatory compositions and formulations and a method for reducing tissue inflammation in tissues such as the bowel, muscle, bone, tendon and joints (e.g., arthritis)." "composition which comprises a chlorine dioxide liberating compound and a protic acid." " Systemic formulations that are administered orally, or by injection into muscles, joint capsules, peritoneum, intralymphatically or directly into inflamed tissue." "The inhibition of PMN influx into a wound site can simultaneously reduce the formation of malondialdehyde and conjugated dienes, suggesting that most of the free radicals generated during the early stage of wound healing are mediated by PMNs"