"The only cleanser with Cl02 Complex to inactivate and remove allergens, irritants and germs that accumulate on the skin. Dermatologist recommended. Safe for all skin types. How AsepticMD Is Different: This helps to unblock pores, preventing the formation of pimples. However, what makes the AsepticMD kit different from other treatments is the rest of the formulation, which contains a unique ingredient called Dioxicare. Dioxicare is derived from chlorine dioxide, one of the most powerful disinfectants known – even stronger than bleach at killing bacteria when tested head-to-head – and bacteria do not become resistant to it. In addition, chlorine dioxide is also one of the only disinfectants that effectively penetrates the sticky, gooey biofilms that protect bacteria. In addition to its effects on bacteria on the skin, Dioxicare has another benefit that is just as important – it deeply cleans the skin and unblocks the pores in a way that no other cleanser can. It does this by breaking the connections, called disulfide bonds, that make keratin stick together. This instantly weakens and loosens the keratin plugs that block the pores. Finally, Dioxicare fights inflammation in the skin. One of the main causes of inflammation are proteins called cytokines. Chlorine dioxide inactivates these cytokines, turning off the excess inflammation in the skin. Despite all of these powerful effects, Dioxicare is safe – it doesn’t irritate or dry out the skin. In fact, chlorine dioxide is so safe that it is used to purify water and sanitize foods, meaning that millions of Americans eat it and drink it every day"

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Disclosed herein are topical compositions comprising a quaternary ammonium salt and optionally ammonium chloride and/or stabilized chlorine dioxide. Also disclosed herein are methods of reducing the s

***!!!!!!!!!***!!!!*** "Chlorine dioxide has been suggested to be a size selective antimicrobial agent, killing micron sized organisms rapidly but causing much less harm to larger organisms compared to hypochlorite solutions [20]. Disinfection of living tissues with aqueous chlorine dioxide solutions appears to be quite safe as bacteria can be killed using low concentrations of chlorine dioxide and short contact times, while much higher concentrations and contact times are required to cause damage to tissue" "In contrast, the toxicity of the chlorine dioxide product increased 4–6 fold as the exposure time increased from one to 24 hours (Fig 4). Although at exposures of 24 hours the concentration of the chlorine dioxide product was 20 fold higher compared to that of sodium hypochlorite to achieve an LC50. This result was consistent whether the toxicity to the skin cells was assessed at 24 or 48 hr" "the very low toxicity (~10%; v/v) of the chlorine dioxide product after one hour of contact increased only slowly over the next 23 hours, suggesting that reducing the exposure time should decrease the likelihood of skin injury. Studies such as this, where “naked” cells in culture are exposed to the test agent, should provide a conservative estimate of tissue injury, especially to intact skin, where the outer cornified epidermal layers are already dead and serve almost exclusively as a protective barrier." "In summary, we report that a stabilized liquid formulation of chlorine dioxide is an effective sporicidal agent, and reduced B. anthracis spore counts by >5 logs in five minutes or less in suspension."

***!!!*** "The USEPA requires products making fungicidal claims to demonstrate disinfectant efficacy against Trychophyton mentagrophytes, also known as "T. ment". Trichophyton species are associated with public health related infections including ring worm and Athlete's Foot. Applied to tests as a spore, this fungi poses a formidable challenge for disinfectant products such that disinfectant products have an EPA stated maximum allowable contact time of 10 minutes to demonstrate total kill. The product tested in this study demonstrated total kill of the test microorganism at contact times of both 1 and 2 minutes."

****!!!!*** [Taiko] "chlorine dioxide, which can cure an intractable skin disease, such as skin disease caused by humanpapilloma virus, against which no effective therapeutic method had been developed" "sodium dihydrogenphosphate as the pH adjuster whose pH is 2.5 to 6.8 as a 5% aqueous solution at 25°C, ****remarkably enhances**** the preservation stability of the chlorine dioxide solution"

"There is disclosed a method for treating dermatologic diseases caused by microbial overgrowth or inflammation, such as psoriasis, fungal infections, eczema, dandruff, acne, genital herpes lesions, and leg ulcers. There is further disclosed an antiviral lubricating composition that is effective in preventing the transmission of the HIV virus and other sexually transmitted diseases. There is also disclosed systemic anti-inflammatory compositions and formulations and a method for reducing tissue inflammation in tissues such as the bowel, muscle, bone, tendon and joints (e.g. arthritis)."

****!!!!**** {Related to Alcide chlorine dioxide product} "Methods for preventing and treating microbial wound infections, especially of peritoneal cavity wounds including those having indwelling catheters, and enhancing wound repair while minimizing adhesions and scar formation involve the infusion or irrigation of the wound with a solution containing a pharmacologically acceptable carrier and chlorine dioxide in an amount ranging from about 5 ppm to 1000 ppm, and having a chlorine dioxide to chlorite ratio of at least 5:1. Typical solutions contain chlorine dioxide in isotonic saline and exhibit a pH of from about 5 to about 7.5. Sodium chlorite is employed in preferred embodiments." "formation of scarring and/or fibrous adhesions. An additional feature of ClO2 and related oxychlorine systems is their capability to inhibit the stimulation of fibroplasia, the proliferation of fibroblast cells and expression of collagen, which ordinarily ensues following wounding. As shown in the examples that follow, the oxychlorines resulting from acidification of chlorite to form chlorous acid significantly inhibits fibroblast proliferation and collagen formation." "A further study confirming the effect of ClO2 on wound healing set out in greater particularity below combines an investigation of the immediate cellular response (chemotaxis) of the body to injury using isolated polymorphonuclear leukocytes, and another investigation assessing the interaction of ClO2 with free radicals which form during the course of tissue repair collagen synthesis. In the former case, ClO2 was found to control chemotaxis by affecting the quality and morphology of the associated polymorphonuclear leukocytes. In the latter case, the ClO2, which is a stable free radical containing one unpaired electron, was found to neutralize the superoxide and related radicals involved in the process of collagen production." "solutions of 350 ppm in buffered saline have been shown to be safely infusable into cows' udders without stimulation of any immune response by the animals" "In contrast to antibiotics, systemic absorption of the compositions of the invention is minimized in treatments using them because of the inorganic nature of chlorine dioxide, and its reductive degradation to chloride as a result of its interaction with organic matter (including bacteria, fungi, and viruses). It is important to note that materials may be non-inflammatory (i.e., not provoke inflammation) but not anti-inflammatory (i.e., counter the effects of inflammation). Chlorine dioxide has been found to be non-inflammatory, by virtue of being infusible into the peritoneal cavity and other body cavities without evoking the inflammatory response, as well as being anti-inflammatory; see the copending U.S. application Ser. No. 08/133,465, filed Oct. 8, 1993, and parent case U.S. Pat. No. 5,252,343, cited and incorporated by reference above. In order to utilize the germ-killing and non-inflammatory qualities of chlorine dioxide, it is preferable to isolate it from chlorites and its acidic form, chlorous acid" " the lactate so formed may enhance angiogenesis, collagen synthesis and deposition, and modulate the response of fibroblasts to growth factors in the wound ...In embodiments where these effects are not desired, organic acids other than lactic acid are employed." "ability of the chlorine dioxide solutions to bring about a marked reduction in Staphylococcus epidermidis biofilms" "The 50 ppm ClO2 solution, on the other hand, is well tolerated by mammalian tissue, as, for example, when used as an eye irrigant, to treat bacterial infections induced in rabbits, to infuse into a cow's udder, or as a uterine douche for mares and cows in the prevention and treatment of endometritis." "a chlorine dioxide concentration of about 7.5 ppm inhibits free radical formation by 74% and at a concentration of 15 ppm, by 100%." "If the solution is prepared in the presence of a phosphate buffer which immediately neutralizes the lactic acid, the formation of chlorine dioxide is inhibited in the system. The solution has no inhibitory effect with rat fetal lung fibroblasts. Thus, it is not chlorite ion that is operative, but ClO2."

****!!!!****{Doses & studies for skin (& maybe internal?) treatments} " treating fungal infections using a metal salt of chlorite alone or in combination with a conventional antifungal agent... topical or systemic."*****[? Statements need verification] "chlorite ions are many times less toxic than chlorine dioxide to animal cells and that maintaining it at a higher pH will allow for a higher concentrations to be used. Concentrations of up to 0.5% in internal fluids have been shown to be acceptable for internal use. Higher dosages are likely to be acceptable also. External use allows for considerably higher concentrations to be used, and even higher concentrations are acceptable for short-term contact." "A pattern observed indicates that sodium chlorite alone at a pH that does not create chlorine dioxide and in combination with conventional antifungal agents is a superior antifungal agent than the antifungal alone against 100% of fungi tested."

***!!!!*** {Includes photos of wound healing} "Three surgical case reports are presented to demonstrate the clinical efficacy of using an improved aqueous solution of chlorine dioxide complex (160 ppm) as a topical antiseptic in the post operative management of serious wounds in dogs"

{Similar to TCDO} "daily moist-wound-treatment (MWT) with polyacrylate hydrogel with (group I) or without (group II) pharmaceutical sodium chlorite (DAC N-055)."

" non-toxic, non-mutagenic and totally harmless to normal healthy tissue. In addition, our ClO2 based products all possess strong anti-inflammatory properties via oxidation of free radicals and elimination of harmful cytokines (chemicals that the body releases in response to a wound or infection). Deactivation of these molecules reduces pain, irritation and scarring." "DentA-ClO2 – Dental Paste: Reduces and helps eliminate the bacteria responsible for periodontitis and gingivitis (which causes bad breath) in dogs and cats. Whitens teeth. Derma-ClO2: Wound Healing Ointment: Promotes healing and prevents scarring from hot spots, scratches, rain rot and fungal or bacterial infection of the skin on all animals. Epi-ClO2 - Shampoo - Non-toxic, non-irritating antiseptic shampoo immediately cleans and deodorizes hair and skin. Soothing emollients relieve irritation and soften hair coat. Eliminates skunk odor. Oti-ClO2 – Ear Cleansing Solution: Gentle, non-toxic ear-cleaning agent formulated to maintain healthy ears in dogs and cats. Treats inflammation (otitis) of the external ear. Podi-ClO2 Green – Antimicrobial Gel: Preventive gel for hoof treatment that eliminates thrush, white line disease, hoof canker, abscesses and other infectious conditions. Podi-ClO2 Liquid – Antimicrobial Liquid: Hoof treatment that eliminates thrush, white line disease, hoof canker, abscesses and other infectious conditions

(2008 originally published) Chlorine dioxide oxidizes and neutralizes free radicals and cytokines. Ingredients in some of Frontier's 20 CD products include catalysts that cause CD to release immediately, wetting agents, etc. Use high concentrations for: removing scars, tooth whitening, horse hoof fungal thrush, nail fungus (400 ppm). Fairly high: wart removal (200 ppm)--[Comment: Could possibly get FDA approval by listing salicylic acid as the active ingredient, & then also including sodium chlorite and lactic acid activator??] (****Includes urea as a wetting agent to help get into skin****). Medium: itchy scalp fungus. Low concentrations: gynegel against STDs (not FDA approved at that time), acne. Other uses: kill yeast in dogs' ears, canker sores, pet shampoo, exfoliant for women's faces, skin protectant including glycerin for men's hands (callouses, scratches), topical that removes pain of sunburn by oxidizing free radicals & cytokines; vaginal disinfectant, cosmesis, sinus flush that quickly relieves rhino colds and acts more slowly on flu; mouth rinse. Toothpaste kills bacteria faster & oxidizes their sulfur compounds & odors, treats periodontal disease, removes biofilm, & whitens enamel. *****!!!**** Treats Raynaud's Syndrome by opening up blood vessels in hands. Did some testing of intravenous injection of monkey for HIV, but dosed too high so killed too much of red blood cells." "When *chlorine* oxidizes organic compounds, it adds a chlorine atom, making the compound carcinogenic and irritating. Chlorine dioxide doesn't."

******!!!!********* "inhaling high concentration ClO2 gases for an extended time can be dangerous for human health because the alveolar membrane is extremely thin (a mere 1-2 microns and in some places even below 1 micron). The effect of ClO2 in these membranes is somewhat counterbalanced, however, by the intense blood circulation there." "O2 can remove biofilms swiftly [12] because it is highly soluble in water and unlike ozone it does not react with the extracellular polysaccharides of the biofilm. This way ClO2 can penetrate into biofilms rapidly to reach and kill the microbes living within the film."

****!!!!**** "In case of clinically diagnosed wound infections, topical wound disinfection was allowed for 5 consecutive days with saline containing 970 ppm chlorine dioxide... wound cleansing and disinfection with gauzes soaked in physiological saline solution containing 320 ppm chlorine dioxide... for 15 minutes... In CL endemic regions with poor infrastructure, bipolar HF-EC is a robust technology to debride CL lesions under local anaesthesia. The combination with DAC N-055 MWT provides additional anti-parasitic, antimicrobial and wound healing effects."

A chlorine dioxide-containing gel was compared with 3 commercially available antimicrobials and 1 antibiotic intended for topical use. This gel was tested at 0.5 X and 4 X and was found to be more effective as a 4 X gel in treating Pseudomonas aeruginosa-infected excised wounds on mice. To further c …

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Chlorine dioxide complex™ is a new molecule to dermatology that is a unique, non-toxic, broad spectrum anti-microbial and keratolytic compound. Chlorine dioxide has been used as an antiseptic in industrial settings for decades, primarily in water treatment facilities for municipal water supplies and …

The tentatively lower rate of relapses and the acceleration of wound closure in a subgroup of patients with parasite persistence warrant future studies on the activity of DAC N-055. sodium chlorite