Body--Topical Uses

"penetrate debris under the nail and remove discoloration due to nail fungus."

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PURPOSE: To provide the titled remedying liquid composed of an aqueous solution containing a chlorine dioxide agent, salicylic acid and assistant components comprising a dermatic growth promoter and an antidesiccant and having advantages of easy applicability, high radical curing ratio and rapid hair growth... EFFECT: It has strong drug action and the infection to man can be completely prevented by the use of a sprayer, etc.

A chlorine dioxide liquid agent comprising dissolved chlorine dioxide gas as a constituent, which is used as a remedy for skin diseases and mucosal diseases to be applied to an infected area in order to improve symptoms of an infected area caused by infection with a pathogenic microorganism Infectious skin and mucous membrane diseases.

****!!!!**** "The chlorine dioxide solution contains dissolved chlorine dioxide gas as a constituent component." " sodium chlorite and potassium chlorite are preferred, and sodium chlorite is most preferred, not only for the reasons of easy availability, but also from the viewpoint of excellent sustainability of chlorine dioxide activity." "acne vulgaris... Chlorine dioxide concentration at the time of dilution: 150 ppm)" "chlorine dioxide liquid with a concentration of 10 ppm or more will inactivate adenoviruses that cause epidemic keratoconjunctivitis, and it is disclosed that the chlorine dioxide liquid does not affect the eyeball even at a concentration of 250 ppm." " By selecting sodium dihydrogen phosphate or a mixture of sodium dihydrogen phosphate and disodium hydrogen phosphate, and using it in combination with sodium chlorite, the storage stability is further improved" "In this way, unnecessary consumption of sodium chlorite is suppressed and sodium chlorite is effectively consumed, so the storage stability is further improved (prolonged), and the concentration of chlorine dioxide fluctuates over time (variation) during storage. ) Is further reduced (not only the decrease in concentration is suppressed, but the increase in concentration is also suppressed"

"also relates to compositions that are useful for topical application, especially to nails and adjacent tissue for the treatment of mycotic and microbial infections." "In additon to the treatment of microbial and mycotic infections, the antimicrobial compositions of the present invention also serve to rid the treatment area of cellular debris that accumulates as a result of the infection." "may further comprise... surfactants... used to stabilize the chlorine dioxide compound in an aqueous solution." "those with the worst nail condition at the beginning showed the highest percentage improvement over the four week period."

"Topically, the tetrachlorodecaoxygen anion complex (TCDO) has a therapeutic effect in wound healing [2, 9] with an increase of pO2 in the capillary blood [3] and systematically in experimental infections [1], It constitutes a negatively charged complex of chlorine and oxygen (Cl4O10)n, MWn=1 = 301.8. Incubation with hemoproteins leads to complex degradation and the appearance of oxygen water in chloride [4], whereby toxic oxygen species are not formed [8]. Heme-ac-tivated TCDO was described to be bactericidal for a number of microbial species [6, 7], to enhance phagocytosis by resident peritoneal macrophages of mice [7], and to stimulate humoral and cellular immunity [1]."

Werner, Sabine, and Richard Grose. Regulation of Wound Healing by Growth Factors and Cytokines. Physiol Rev 83: 835–870, 2003; 10.1152/physrev.00032.2002.—Cutaneous wound healing is a complex proce...

"15 patients who were treated with Vacuum-Assisted Closure (VAC) negative pressure therapy system"

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"contacting a stable precursor with a transition metal in a buffered aqueous medium."

"63 transcutaneous measurements of oxygen pressure and 36 series of infrared thermograms in 9 hypoxic wounds showed that topical administration of tetrachlorine decaoxide (TCDO) results in increased oxygen supply of the wound. This effect is associated with improvement of the skin temperature and decrease of the pathological temperature difference between the wound and the surrounding tissue. TCDO can induce physiological wound healing, since it improves the mechanisms of the immune defence system, wound cleansing, granulation, and epithelialization in slow-healing wounds."

{Regard sodium chlorite contact lens solution}

To evaluate the efficacy and safety of newly formulated brimonidine (0.1% brimonidine tartrate preserved with sodium chlorite: brimonidine) as add-on therapy in on-treatment Japanese normal-tension glaucoma (NTG) patients.Brimonidine was added to on-treatment ...

"In 1986, a randomized controlled trial (RCT) has shown that moist dressing with a sodium chlorite (NaClO2)-based drug is beneficial for rapid wound cleansing and granulation [3]. If not further concentrated under vacuum (which is commonly practiced with industrial NaClO2), pharmaceutical chlorite contains a chlorine peroxide contaminant, formerly called tetradecachlorooxygen (TCDO), a chemical name refuted by the German Health Authorities [4]. The chlorine peroxide seems to be important for systemic regenerative effects in stem cell compartments of rats [5],[6]. Recent advances in bacterial heme protein biochemistry [7],[8] have reformed our understanding of chlorite biochemistry [9] showing that in vivo reactions of chlorite with heme analogues can either produce hypochlorite, which in turn can react with H2O2 to form singlet oxygen 1O2, or which can dismutate to Cl- and 1O2. In animal experiments with non-thermal (NTP) [10] or cold atmospheric plasma (CAP) [11] lower μM levels 1O2 have shown to induce wound healing."

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Introduction: Diabetic ulcer is a very common entity encountered in the general surgical practice. The problem needs keen interest and meticulous wound care for its management to prevent serious complications of these infected and gangrenous ulcers. Objective: The objective of the study was to compare the efficacy of honey dressing and oxoferin (tetrachlorodecaoxide) dressing in the management of infected wounds in diabetic amputated limbs. Study Design: Randomized clinical trial. Setting: Surgical Unit-IV of Districted head quarter hospital Faisalabad. Subjects and Methods: The total sample size comprises of 98 patients were divided into two groups A and B. Group A was treated with honey dressing while group B was treated With oxoferin (tetrachlorodecaoxide) dressingArea of the wounds to be dressed was measured in two largest dimensions and noted in cm. Sterile gauzes soaked in commercially available tube packed honey and oxoferin (tetrachlorodecaoxide) solution were applied over the wounds. Outcome of the both methods were assessed by measuring of the size of the wound at presentation and then after one week. Results: Significant decrease in wound size in oxoferin group was in 24 patients (49 %) and in honey group was in 11 patients (22.4 %) Conclusion: Although the clinical experience detailed in this study showed better results to oxoferin as compare to honey dressing, more quality randomised controlled trials are needed to provide evidence to encourage the use of honey in wound care.

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Oxoferin 0.002% Solution is used in the treatment of Wound infection. View Oxoferin 0.002% Solution (bottle of 30 ml Solution) uses, composition, side-effects, price, substitutes, drug interactions, precautions, warnings, expert advice and buy online at best price on 1mg.com

Product Highlight - OXOFERIN

"Oxoferin (Sterile) solution is a Brookes specialty, being the only product of its kind available for the treatment of all types of chronic problems wounds. Oxoferin Sterile Solution is a research of Oxo cheme Transformation Sciences, Germany. Oxoferin (Topical Solution) contains Tetrachlorodecaoxide and enjoys the distinction of being the only product that contains oxygen in the solution and stable form. One more exclusive benefit that makes Oxoferin solution (sterile) stand out is its ability to kill all pathogens, though it does not contain any antibiotic. Oxoferin solution (sterile) works on both cleansing and regenerative phases of wound healing. Oxoferin is an immune-modulator Agent."