Body--Topical Uses

"Conventional treatments involve radical removal of affected hoof tissue resulting in hoof mutilation and usually transportation to a clinic; therefore, the goal of the study was to find a method of treatment that can be done in the field" "Ciderm EQ (sold under the Trade name White Lightning Gel)" "This treatment appears to be as or more effective than radical hoof mutilation" "Treatment for white line disease has usually involved radical hoof trimming in conjunction with some sort of topical antimicrobial therapy to reduce the incidence of secondary infections. Although these methods have seen variable success, they often result in secondary complications or a noticeable degree of loss of function... Chlorine dioxide gas, generated from a two-part gel, should be an effective antimicrobial agent in this circumstance due to its broad antibacterial and antifungal spectrum in addition to its ability to access small recesses that may harbor such organisms and be protected from other topical treatments." "Horses that started out with the highest lesion volumes also had the greatest percentage reduction in lesion volumes at the end of the 12 week study period. So it seems that even though different environments correlated with disease severity initially, the environment did not affect the response to therapy."

{Mucor sp is one of the types of fungi that can cause horse hoof wall separation.} White line disease " is restricted to the inner-most area of the stratum medium. This area has a moisture content of 75 percent in a normal hoof. " "This potent disinfectant used on a properly prepared hoof eliminated the presence of fungal spores. I have had positive results using this chemical on thrush, canker, scratches and rainrot. Chlorine dioxide at 20,000 ppm is activated using 1 deciliter chlorine dioxide, 1 deciliter of vinegar with 4 liters of water for a safe effective method of treating fungal infections of the horse’s hoof."

"most crucial step was to neutralize any active infection. This was done with Grand Circuit’s White Lightning, a chlorine dioxide in an aqueous base (water). One cup of White Lightning is mixed with an equal portion of acetic acid (white vinegar) and further diluted with 1 gallon of water to make the soaking solution" "Chlorine dioxide works by dissolving the biofilms (protective layer surrounding organisms), then it alters the pH, which thereby neutralizes the organism itself. It is effective against fungi and bacteria, so it immediately destroys thrush. It also is a treatment for canker, white line disease and other hoof ailments. When the infection is highly advanced, you can often smell it, much like thrush. White Lightning breaks down the hydrogen-sulfur bond, which is where the putrid smell comes from. Do not be surprised if after the first soak the smell dissipates."

White Lightning chlorine dioxide treatment for horses for hoof thrush, skin fungus and white line disease.

****!!!!*** [Taiko] "chlorine dioxide, which can cure an intractable skin disease, such as skin disease caused by humanpapilloma virus, against which no effective therapeutic method had been developed" "sodium dihydrogenphosphate as the pH adjuster whose pH is 2.5 to 6.8 as a 5% aqueous solution at 25°C, ****remarkably enhances**** the preservation stability of the chlorine dioxide solution"

****!!!!*** "effective amounts of an irritation reducing compound selected from the group consisting of allantoin, glycerine, aloe vera and mixtures, thereof, in a chlorine dioxide generating composition will substantially reduce skin irritation which is caused by chlorine dioxide exposure to the skin."

"There is disclosed a method for treating dermatologic diseases caused by microbial overgrowth or inflammation, such as psoriasis, fungal infections, eczema, dandruff, acne, genital herpes lesions, and leg ulcers. There is further disclosed an antiviral lubricating composition that is effective in preventing the transmission of the HIV virus and other sexually transmitted diseases. There is also disclosed systemic anti-inflammatory compositions and formulations and a method for reducing tissue inflammation in tissues such as the bowel, muscle, bone, tendon and joints (e.g. arthritis)."

****!!!!**** {Related to Alcide chlorine dioxide product} "Methods for preventing and treating microbial wound infections, especially of peritoneal cavity wounds including those having indwelling catheters, and enhancing wound repair while minimizing adhesions and scar formation involve the infusion or irrigation of the wound with a solution containing a pharmacologically acceptable carrier and chlorine dioxide in an amount ranging from about 5 ppm to 1000 ppm, and having a chlorine dioxide to chlorite ratio of at least 5:1. Typical solutions contain chlorine dioxide in isotonic saline and exhibit a pH of from about 5 to about 7.5. Sodium chlorite is employed in preferred embodiments." "formation of scarring and/or fibrous adhesions. An additional feature of ClO2 and related oxychlorine systems is their capability to inhibit the stimulation of fibroplasia, the proliferation of fibroblast cells and expression of collagen, which ordinarily ensues following wounding. As shown in the examples that follow, the oxychlorines resulting from acidification of chlorite to form chlorous acid significantly inhibits fibroblast proliferation and collagen formation." "A further study confirming the effect of ClO2 on wound healing set out in greater particularity below combines an investigation of the immediate cellular response (chemotaxis) of the body to injury using isolated polymorphonuclear leukocytes, and another investigation assessing the interaction of ClO2 with free radicals which form during the course of tissue repair collagen synthesis. In the former case, ClO2 was found to control chemotaxis by affecting the quality and morphology of the associated polymorphonuclear leukocytes. In the latter case, the ClO2, which is a stable free radical containing one unpaired electron, was found to neutralize the superoxide and related radicals involved in the process of collagen production." "solutions of 350 ppm in buffered saline have been shown to be safely infusable into cows' udders without stimulation of any immune response by the animals" "In contrast to antibiotics, systemic absorption of the compositions of the invention is minimized in treatments using them because of the inorganic nature of chlorine dioxide, and its reductive degradation to chloride as a result of its interaction with organic matter (including bacteria, fungi, and viruses). It is important to note that materials may be non-inflammatory (i.e., not provoke inflammation) but not anti-inflammatory (i.e., counter the effects of inflammation). Chlorine dioxide has been found to be non-inflammatory, by virtue of being infusible into the peritoneal cavity and other body cavities without evoking the inflammatory response, as well as being anti-inflammatory; see the copending U.S. application Ser. No. 08/133,465, filed Oct. 8, 1993, and parent case U.S. Pat. No. 5,252,343, cited and incorporated by reference above. In order to utilize the germ-killing and non-inflammatory qualities of chlorine dioxide, it is preferable to isolate it from chlorites and its acidic form, chlorous acid" " the lactate so formed may enhance angiogenesis, collagen synthesis and deposition, and modulate the response of fibroblasts to growth factors in the wound ...In embodiments where these effects are not desired, organic acids other than lactic acid are employed." "ability of the chlorine dioxide solutions to bring about a marked reduction in Staphylococcus epidermidis biofilms" "The 50 ppm ClO2 solution, on the other hand, is well tolerated by mammalian tissue, as, for example, when used as an eye irrigant, to treat bacterial infections induced in rabbits, to infuse into a cow's udder, or as a uterine douche for mares and cows in the prevention and treatment of endometritis." "a chlorine dioxide concentration of about 7.5 ppm inhibits free radical formation by 74% and at a concentration of 15 ppm, by 100%." "If the solution is prepared in the presence of a phosphate buffer which immediately neutralizes the lactic acid, the formation of chlorine dioxide is inhibited in the system. The solution has no inhibitory effect with rat fetal lung fibroblasts. Thus, it is not chlorite ion that is operative, but ClO2."

****!!!!****{Doses & studies for skin (& maybe internal?) treatments} " treating fungal infections using a metal salt of chlorite alone or in combination with a conventional antifungal agent... topical or systemic."*****[? Statements need verification] "chlorite ions are many times less toxic than chlorine dioxide to animal cells and that maintaining it at a higher pH will allow for a higher concentrations to be used. Concentrations of up to 0.5% in internal fluids have been shown to be acceptable for internal use. Higher dosages are likely to be acceptable also. External use allows for considerably higher concentrations to be used, and even higher concentrations are acceptable for short-term contact." "A pattern observed indicates that sodium chlorite alone at a pH that does not create chlorine dioxide and in combination with conventional antifungal agents is a superior antifungal agent than the antifungal alone against 100% of fungi tested."

***!!!!*** {Includes photos of wound healing} "Three surgical case reports are presented to demonstrate the clinical efficacy of using an improved aqueous solution of chlorine dioxide complex (160 ppm) as a topical antiseptic in the post operative management of serious wounds in dogs"

"Keratosis pilaris (KP) is a skin condition in which white bumps appear" "New unproven treatments include topical chlorine dioxide complex wash,"

" Sodium chlorite generates chlorine dioxide which is very effective in killing Gram+ and Gram- bacteria, yeasts and fungi, subsequently breaking down into the components of natural tears – salt, water and oxygen."

"Preferably, the liquid medium has sufficient chlorine dioxide precursor so as to have a potential of producing chlorine dioxide in the range of about 0.002 % to about 3% by weight, based on the total weight of the liquid medium including the chlorine dioxide precursor or precursors." "A series of solutions was prepared using different concentrations of a stabilized chlorine dioxide product, sold by Bio-cide International, Inc. under the trademark Purogene. The stabilized chlorine dioxide product included 2.0% by weight of potential (ultimate yield) chlorine dioxide and 0.085% by weight of sodium carbonate."

"1 ppm Purite™=1 ppm stabilized chlorine dioxide 1 ppm Purite™=1.25 ppm chlorite ion 1 ppm Purite™=1.6761 ppm sodium chlorite 1 ppm Purite™=2.1216 ppm technical grade* sodium chlorite Technical grade sodium chlorite contains about 80% NaCIO2, 13% NaCl, 5% Na2 CO3 and 2% NaClO3." "Preferably, there is present from about 0.01 % (w/v) to about 0.05% (w/v), and even more preferably about 0.015% (w/v) to about 0.03% (w/v) stabilized chlorine dioxide present in the solution."

2010 {in Chinese} "Chlorine dioxide slow release gel has a broad-spectrum antibacterial effect, and is satisfied with the therapeutic effect modeled on the back trauma of rabbits. "

"ii) as a topical antiseptic for application to body parts, iii) to prevent or deter scar formation; iv) to treat dermatological disorders such as wounds, burns, ulcers, psoriasis, acne and other scar forming lesions; and v) to treat ophthalmic disorders such as infections, inflamation, dry eye, wound healing, and allergic conjunctivities." "The anti-microbial composition of the present invention is at a pH range between about 6.0 and about 8.8."

"Chlorine dioxide aids inrelieving pain after wisdom tooth removal and enhancesthe healing process following oral surgical procedures .According to a study... chlorine dioxide is capable of completely killing Enterobacter faecalis within 30 minutes at higher concentrations, making chlorine dioxide an effective endodontic irrigant." "The delayed healing in the Penetrater chlorine dioxide oral gel group may be due to a loweramount of collagen in the wound tissue and to the lower number of myofibroblasts, which play a crucial role in woundcontraction" "The amounts of protein in wounds treated with Aftamed gel or Intrasite gel were significantly increased compared with the amount in the chlorine dioxide gel-treated group."

{Note: "Activated" sodium chlorite (chlorine dioxide) has also been shown to be safe and effective at appropriate doses for topically treating wounds}

"29 patients underwent local treatment with TCDO (Oxoferin) while Beta-isodona was used in 31 cases." "Oxoferin induces a development of granulation tissue on exposed tendons, bones, and fasciae and the granular tissue is of much better quality than after treatment with Betaisodona. Concerning its effect on the degree of contamination, Oxoferin proved to be at least as efficacious as the established and effective antiseptic Betaisodona. Both substances are tolerated well and the application is simple"

Contains 160 ppm chlorine dioxide

{Similar to TCDO} "daily moist-wound-treatment (MWT) with polyacrylate hydrogel with (group I) or without (group II) pharmaceutical sodium chlorite (DAC N-055)."

Local tetrachlorodecaoxygen anion complex (TCDO) had three therapeutic effects in difficult wounds, substantiated on day 14 in a multicentre double-bl…

Master Mineral Solution Testimonials: Disinfectant Success stories. Videos and Writings. MMS was discovered by Jim Humble in 1996 to be an effective solution for Malaria, and since that time according to user reports; much more.

"a 1:10 dilution of a MECA spray (metastabilized chlorous acid/chlorine dioxide), twice weekly for 3–4 weeks using about 8 ounces per rabbit at each application"

Rabbits with ringworm can be treated "with a dilution of a metastabilized chlorous acid-chlorine dioxide compound applied as either a dip or a spray".

Ringworm can be treated

" non-toxic, non-mutagenic and totally harmless to normal healthy tissue. In addition, our ClO2 based products all possess strong anti-inflammatory properties via oxidation of free radicals and elimination of harmful cytokines (chemicals that the body releases in response to a wound or infection). Deactivation of these molecules reduces pain, irritation and scarring." "DentA-ClO2 – Dental Paste: Reduces and helps eliminate the bacteria responsible for periodontitis and gingivitis (which causes bad breath) in dogs and cats. Whitens teeth. Derma-ClO2: Wound Healing Ointment: Promotes healing and prevents scarring from hot spots, scratches, rain rot and fungal or bacterial infection of the skin on all animals. Epi-ClO2 - Shampoo - Non-toxic, non-irritating antiseptic shampoo immediately cleans and deodorizes hair and skin. Soothing emollients relieve irritation and soften hair coat. Eliminates skunk odor. Oti-ClO2 – Ear Cleansing Solution: Gentle, non-toxic ear-cleaning agent formulated to maintain healthy ears in dogs and cats. Treats inflammation (otitis) of the external ear. Podi-ClO2 Green – Antimicrobial Gel: Preventive gel for hoof treatment that eliminates thrush, white line disease, hoof canker, abscesses and other infectious conditions. Podi-ClO2 Liquid – Antimicrobial Liquid: Hoof treatment that eliminates thrush, white line disease, hoof canker, abscesses and other infectious conditions

A method for treating nail fungus by soaking the infected nail(s) in a dilute solution of chlorine dioxide in water. "using a solution of chlorine dioxide in water containing a minimum of 80 parts per million chlorine dioxide as the treating agent."