Body--Topical Uses

Background and Purpose. This study aimed to evaluate the wound healing activities of Aftamed and chlorine dioxide gels in streptozotocin-induced diabetic rats. Experimental Approach. Forty-eight Sprague Dawley rats were chosen for this study, divided into 4 groups. Diabetes was induced. Two-centimet …

Background and Purpose. This study aimed to evaluate the wound healing activities of Aftamed and chlorine dioxide gels instreptozotocin-induced diabetic rats. Experimental Approach. Forty-eight Sprague Dawley rats were chosen for this study, divided into 4 groups. Diabetes was induced. Two-centimeter-diameter full-thickness skin excision wounds were created. Animals were topically treated twice daily. Groups 1, the diabetic control group, were treated with 0.2 mL of sterile distilled water. Group 2 served as a reference standard were treated with 0.2 mL of Intrasite gel. Groups 3 and 4 were treated with 0.2 mL of Aftamed and 0.2 mL of chlorine dioxide gels respectively. Granulation tissue was excised on the 10th day and processed for histological and biochemical analysis. The glutathione peroxidase ,superoxide dismutase activities and the malondialdehyde (MDA) levels were determined. Results. Aftamed-treated wounds exhibited significant increases in hydroxyproline, cellular proliferation, the number of blood vessels, and the level of collagen synthesis. Aftamed induced an increase in the free radical-scavenging enzyme activity and significantly reduced the lipid peroxidation levels in thewounds as measured by the reduction in the MDA level. Conclusions. This study showed that Aftamed gel is able to significantly accelerate the process of wound healing in diabetic rats.

We have invented a simple technique to produce high purity chlorine dioxide solutions and proved that ClO2 is a size selective antimicrobial agent. Its dilute solutions are not harmful for humans but can kill microbes within millisecons. In addition bacteria are not able to...

FutureCow offers the only Teat Scrubber that utilizes the best cleaning solution option, Chlorine Dioxide, in the teat cleaning process.

WuzaWart contains DioxiCare, Frontier's proprietary Chlorine Dioxide Complex. Chlorine dioxide along with glycerin quickly penetrate the wart tissue and attack the papilloma virus which causes the wart. This virus is anaerobic (wants to avoid ...

Says contains 120 ppm stable chlorine dioxide. Management of the underlying disease such a flea bite dermatitis, diabetes, tumor, etc must also accompany treatment of the topical infection with Ciderm Topical Antiseptic. If used in conjunction with other topical medications such as a steroids or antibiotics do not use Ciderm Topical Antiseptic Solution at the same time. Wait at least 10 mins after applying the Ciderm SP before applying other topical agents to avoid oxidation of the other medication.

3 treatments in dogs, & in vitro

{Wound treatment} {Graphs include decrease in chlorine dioxide (ClO2) as a function of time in a protein-rich environment, log reduction of pathogens (including biofilm), etc}

****!!!!****!!!** "There is disclosed a method for treating dermatologic diseases caused by microbial overgrowth or inflammation, such as psoriasis, fungal infections, eczema, dandruff, acne, genital herpes lesions, and leg ulcers. There is further disclosed an antiviral lubricating composition that is effective in preventing the transmission of the HIV virus and other sexually transmitted diseases. There is also disclosed systemic anti-inflammatory compositions and formulations and a method for reducing tissue inflammation in tissues such as the bowel, muscle, bone, tendon and joints (e.g., arthritis)." "composition which comprises a chlorine dioxide liberating compound and a protic acid." " Systemic formulations that are administered orally, or by injection into muscles, joint capsules, peritoneum, intralymphatically or directly into inflamed tissue." "The inhibition of PMN influx into a wound site can simultaneously reduce the formation of malondialdehyde and conjugated dienes, suggesting that most of the free radicals generated during the early stage of wound healing are mediated by PMNs"

Horse hoof treatment

Chlorine dioxide hoof bath treatment for digital dermatitis ( hairy heel warts), the most common infectious cause of lameness in dairy cattle

****{May categorically be considered usable as a "medical treatment"?, in addition to as "topical treatment". --Uncertain whether received approval for organic production. Apparently has been approved at a minimum as "topical" treatment in general production.}

Diluted form of chlorite-based WF10 (Tetrachlorodecaoxide/TCDO)

The tentatively lower rate of relapses and the acceleration of wound closure in a subgroup of patients with parasite persistence warrant future studies on the activity of DAC N-055. sodium chlorite

Both drugs are efficacious. Tetrachlorodecaoxide yields healthy granulation tissue earlier. Both drugs appear to be safe for application.

{Includes Alcide chlorine dioxide} "The repair processes of incised wounds depend, in part, on fibroplasia induced by soluble mediators from monocytic macrophages. Two topical antimicrobials were evaluated, each of which effectively controlled wound sepsis and yet each had widely different effects on fibroplasia and wound strength." "Alcide-treated wounds incorporated less than 50% of the amount of 14C-proline than did the wounds treated with C31G. However, Alcide-treated wounds epithelialized as rapidly as did control wounds, and had minimal scar formation. Microscopic evaluations indicated greatly reduced inflammatory infiltrates in Alcide-treated wounds, indicating that reduced wound strength may be associated with lack of fibroblast-stimulating activity by monocytes. "

Three surgical case reports are presented to demonstrate the clinical efficacy of using an improved aqueous solution of chlorine dioxide complex ******(160 ppm) as a topical antiseptic in the post operative management of serious wounds in dogs.