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Pure&Clean hypochlorous acid
Pure&Clean hypochlorous acid
Testimonials-Pure&Clean, we are focused on helping people live better lives in an increasingly contaminated world. Our vision is to change global healthcare.
·pureandclean.us·
Pure&Clean hypochlorous acid
Heme-iron in lipid oxidation
Heme-iron in lipid oxidation
Oxygen transport, oxygen storage and oxygen activation in aerobic organisms depend on the iron porphyrin moiety in heme proteins. Under fluctuating ox…
·sciencedirect.com·
Heme-iron in lipid oxidation
Effect of low doses of biocides on the antimicrobial resistance and the biofilms of Cronobacter sakazakii and Yersinia enterocolitica
Effect of low doses of biocides on the antimicrobial resistance and the biofilms of Cronobacter sakazakii and Yersinia enterocolitica
"Treatment of biofilms for 10 minutes with disinfectants at 1MIC or 2MIC reduced the biovolume of live cells. PAA (YE) and BZK (CS and YE) at 1MIC did not alter the percentage of dead cells relative to non-exposed biofilms, and their effect of countering biofilm was due principally to the detachment of cells. These results suggest that doses of PAA and BZK close to MICs might lead to the dissemination of live bacteria from biofilms with consequent hazards for public health."
·nature.com·
Effect of low doses of biocides on the antimicrobial resistance and the biofilms of Cronobacter sakazakii and Yersinia enterocolitica
Clean Chemistry Issued New Patents for Water Treatment Technology
Clean Chemistry Issued New Patents for Water Treatment Technology
"PeroxyMAX, one of the chemistries covered under the patents is the safest, most effective solution for the treatment of fresh and produced water for hydraulic fracturing. It enables separations in recovered fluids, floating oil and dropping solids and controls bacteria in a more efficient manner than more dangerous and corrosive alternatives on the market like chlorine dioxide."
·businesswire.com·
Clean Chemistry Issued New Patents for Water Treatment Technology
Redox regulation by reversible protein S-thiolation in bacteria | Microbiology
Redox regulation by reversible protein S-thiolation in bacteria | Microbiology
Low molecular weight (LMW) thiols function as thiol-redox buffers to maintain the reduced state of the cytoplasm. The best studied LMW thiol is the tripeptide glutathione (GSH) present in all eukaryotes and Gram-negative bacteria. Firmicutes bacteria, including Bacillus and Staphylococcus species utilize the redox buffer bacillithiol (BSH) while Actinomycetes produce the related redox buffer mycothiol (MSH). In eukaryotes, proteins are post-translationally modified to S-glutathionylated proteins under conditions of oxidative stress. S-glutathionylation has emerged as major redox-regulatory mechanism in eukaryotes and protects active site cysteine residues against overoxidation to sulfonic acids. First studies identified S-glutathionylated proteins also in Gram-negative bacteria. Advances in mass spectrometry have further facilitated the identification of protein S-bacillithiolations and S-mycothiolation as BSH- and MSH-mixed protein disulfides formed under oxidative stress in Firmicutes and Actinomycetes, respectively. In Bacillus subtilis, protein S-bacillithiolation controls the activities of the redox-sensing OhrR repressor and the methionine synthase MetE in vivo. In Corynebacterium glutamicum, protein S-mycothiolation was more widespread and affected the functions of the maltodextrin phosphorylase MalP and thiol peroxidase (Tpx). In addition, novel bacilliredoxins (Brx) and mycoredoxins (Mrx1) were shown to function similar to glutaredoxins in the reduction of BSH- an...
·frontiersin.org·
Redox regulation by reversible protein S-thiolation in bacteria | Microbiology
Healthcare Workers
Healthcare Workers
{Note: Appropriate concentrations to use need to be verified) Disinfecting with sodium hypochlorite: "Based on the EPA List N: Disinfectants for Use Against SARS-CoV-2 products, 2500 ppm (0.25%) for 5 minutes is effective. Most readily available bleach is approximately 6% so 2/3 cup of bleach per gallon of cold tap water (1:24 dilution) for 5 minutes is appropriate." "If a lower concentration of bleach is desired, the EPA standard disinfection rate for hypochlorite products is 600 ppm for 10 minutes."
·cdc.gov·
Healthcare Workers
DHS Science and Technology Evaluation of Disinfectants against SARS-CoV-2 ~US Department of Homeland Security
DHS Science and Technology Evaluation of Disinfectants against SARS-CoV-2 ~US Department of Homeland Security
****!!!!**** {Direct testing against SARS-CoV-2} "To better inform the choice and use of disinfectants by DHS operators against SARS-CoV-2, the NBACC performed studies to evaluate the effectiveness of several products to reduce SARS-CoV-2 contamination when it was in simulated respiratory fluids. Disinfectants were tested against both wet and dried virus droplets to simulate disinfection of fresh and old contamination. No pre-cleaning or wiping was done during these tests to model a high tempo operations scenario where disinfectant is simply applied onto a potentially contaminated surface without precleaning or wiping"
·dhs.gov·
DHS Science and Technology Evaluation of Disinfectants against SARS-CoV-2 ~US Department of Homeland Security
Indirect Photodegradation of Dissolved Free Amino Acids: The Contribution of Singlet Oxygen and the Differential Reactivity of DOM from Various Sources
Indirect Photodegradation of Dissolved Free Amino Acids: The Contribution of Singlet Oxygen and the Differential Reactivity of DOM from Various Sources
"Only four of the eighteen free amino acid residues examined were found to be photolabile under environmentally relevant conditions: histidine, methionine, tyrosine, and tryptophan."
·pubs.acs.org·
Indirect Photodegradation of Dissolved Free Amino Acids: The Contribution of Singlet Oxygen and the Differential Reactivity of DOM from Various Sources
Virucidal Activity of Disinfectants Against Parvoviruses and Reference Viruses
Virucidal Activity of Disinfectants Against Parvoviruses and Reference Viruses
Not all biocides present the same efficacy against viruses, with ethanol being poorly efficient and heat as well as sodium hypochlorite presenting limited efficacy depending on conditions tested. In our experiments, tested bio-cides containing peracetic acid presented very good overall virucidal efficacy; however, observed differences in susceptibility of different parvovirus species should be taken into account. Atmos-pheric decontamination with VHP presented good effica-cy against all tested viruses including parvoviruses even in the presence of blood. In general, this type of technol-ogy is used following pre-cleaning, although it has been shown to be very effective even under grossly soiled con-ditions
·journals.sagepub.com·
Virucidal Activity of Disinfectants Against Parvoviruses and Reference Viruses
Human and Environmental Toxicity of Sodium Lauryl Sulfate (SLS): Evidence for Safe Use in Household Cleaning Products
Human and Environmental Toxicity of Sodium Lauryl Sulfate (SLS): Evidence for Safe Use in Household Cleaning Products
Environmental chemical exposure is a major concern for consumers of packaged goods. The complexity of chemical nomenclature and wide availability of scientific research provide detailed information but lends itself to misinterpretation by the lay person. ...
·ncbi.nlm.nih.gov·
Human and Environmental Toxicity of Sodium Lauryl Sulfate (SLS): Evidence for Safe Use in Household Cleaning Products
Precursor Material Qualification (metal powders)
Precursor Material Qualification (metal powders)
[Methods to help address variability] The lack of repeatable process outcomes from additive manufacturing (AM) has been broadly acknowledged as an impediment to widespread implementation. While most R&D efforts have been focused on in-process parameters and metrics and how they both relate to final part properties (e.g., microstructure, mechanical properties), much less focus has been placed on the precursor material. The Additive Manufacturing Standards Collaboration (AMSC) has identified ten gaps in the standardization of characterization of precursor material (PCM), of which five are deemed a ‘medium’ or ‘high’ priority indi...
·www.nist.gov·
Precursor Material Qualification (metal powders)
Decontamination Efficacy of Three Commercial-Off-The-Shelf (COTS) Sporicidal Disinfectants on Medium-Sized Panels Contaminated with Surrogate Spores of Bacillus anthracis
Decontamination Efficacy of Three Commercial-Off-The-Shelf (COTS) Sporicidal Disinfectants on Medium-Sized Panels Contaminated with Surrogate Spores of Bacillus anthracis
In the event of a wide area release and contamination of a biological agent in an outdoor environment and to building exteriors, decontamination is likely to consume the Nation’s remediation capacity, requiring years to cleanup, and leading to incalculable economic losses. This is in part due to scant body of efficacy data on surface areas larger than those studied in a typical laboratory (5×10-cm), resulting in low confidence for operational considerations in sampling and quantitative measurements of prospective technologies recruited in effective cleanup and restoration response. In addition to well-documented fumigation-based cleanup efforts, agencies responsible for mitigation of contaminated sites are exploring alternative methods for decontamination including combinations of disposal of contaminated items, source reduction by vacuuming, mechanical scrubbing, and low-technology alternatives such as pH-adjusted bleach pressure wash. If proven effective, a pressure wash-based removal of Bacillus anthracis spores from building surfaces with readily available equipment will significantly increase the readiness of Federal agencies to meet the daunting challenge of restoration and cleanup effort following a wide-area biological release. In this inter-agency study, the efficacy of commercial-of-the-shelf sporicidal disinfectants applied using backpack sprayers was evaluated in decontamination of spores on the surfaces of medium-sized (∼1.2 m2) panels of steel, pressure-treated (PT) lumber, and brick veneer. Of the three disinfectants, pH-amended bleach, Peridox, and CASCAD evaluated; CASCAD was found to be the most effective in decontamination of spores from all three panel surface types.
·journals.plos.org·
Decontamination Efficacy of Three Commercial-Off-The-Shelf (COTS) Sporicidal Disinfectants on Medium-Sized Panels Contaminated with Surrogate Spores of Bacillus anthracis