*****!!!**** {Includes graphs of bactericidal effects at different temperatures and pH} "Chlorine dioxide reacts primarily by oxidation; however, chlorine reacts by both oxidation and electrophilic substitution to yield volatile and nonvolatile chlorinated organic substances (THMs)." "1.34 lb of pure sodium chlorite will react with 0.5 lb of chlorine to produce 1.0 lb of chlorine dioxide. However, since dry technical sodium chlorite is 80% active, the reaction takes 1.68 lb of technical sodium chlorite. Usually a slight excess of chlorine should be used to insure that the reaction solution has a pH value between 2-4. This will produce chlorine dioxide more efficiently" "chlorine dioxidecan also be prepared by mixing sodium hypochlorite bleaching solution with sodium chlorite and an acid... The reaction with sulfuric acid as shown... produces the highest purity chlorine dioxide. Other inorganic and organic acids may be used and hydrochloric acid reportedly produces the most efficient generation of chlorine dioxide." "Sodium chlorite may cause anemia by oral exposure and has low toxicity by dermal exposure. Dry sodium chlorite has an oral LD50 (rat) of 165 mg/kg and sodium chlorite solutions have an oral LD50 (rat) of 350 mg/kg. Sodium chlorite dry and solution products have a dermal LD50 (rabbit) of greater than 2 g/kg." "Sodium chlorite, dry, is a fire or explosion hazard when contaminated with combustible material... Sodium chlorite, solution, also becomes a fire or explosion hazard if allowed to dry and can ignite... Continue to keep damp."

****!!!!**** "The method of chlorine dioxide bacterial kill at low ppm concentration seems to occur by the disruption of protein synthesis and enzyme inactivation.48 49 This is similar to the "time honored", non-toxic mechanism of some common antibiotics. Oxidation of RNA and DNA do not appear to take place, or are at least unimportant in the process. The site of action lies in the soluble fraction of the cell and there appears to be no damage to whole structural components such as ribosomes" "At high ClO2 ppm, the method of rapid bacterial and viral kill appears to be the softening and destroying of the cell wall or viral capsid.52 Human cells do not have similar cell walls and are apparently unaffected. Our skin and bodies are likely protected from the general oxidative effects of ClO2 by the many reducing agents in our cells and blood, such as catalase, glutathione, superoxide dismutase, vitamins E, C, A, B complex, uric acid, zinc and selenium. This is probably the same internal protective mechanism that prevents damage from oxygen and free radicals. Bacteria and viruses do not contain most of these reducing compounds. Because ClO2 is a strong oxidizing agent and also itself a free radical, it quickly neutralizes reactive molecules,such as ****cytokines**** and oxygen free-radicals such as NO•, O2¯, H2O2, HClO, and OH •that are produced in the body by macrophages. These oxygen compounds are released in response to stress or infection and cause inflammation and pain. Other potential irritants found in wounds are similarly oxidized or reduced, such as leukotrienes, TNF, and interleukin. This neutralizing property of ClO2, combined with its ability to completely disinfect, makes IOXIDERM and DIOXIGUARD ideal wound medications. Unlike iodine compounds, or chlorhexidine, healing is not impeded.53 54 Veterinarians have been treating deep wounds and abscesses on tigers and elephants as well as dogs and cats with outstanding success.55 DIOXIDERM GEL had similar striking results on human (otherwise non-healing) diabetic ulcers." "The NOAEL, from animal ingestion studies involving ClO2 and ClO2 ̄, ranges to 100 ppmv[???] about the concentration of Frontier's DioxiDerm gel for topical use. . Water solutions of ClO2 will remain stable for several months if stored in a glass or PET bottle. “Stabilized” chlorine dioxide, which is a buffered solution ofsodium chlorite, does not release ClO2 until the pH of the solution is brought below 3." "Many nutrition and toxicology studies have been performed assessing chlorine dioxide's effect on flour. Treatment of flour with 200 ppm, fed to rats, had no effect after several generations.24,25 Flour treated with up to 500 ppm (5 times the concentration in DioxiCure Gel) fed to puppies had no untoward effect.26 Thirteen human subjects fed experimentally for six weeks with flour products that were treated with doses up to 400 ppm had no detectable toxic symptoms.27 Flour bleached with normal dosage is not reduced appreciably in nutritive value.28 Essential fatty acids are generally not effected, but tocopherol and cystine are oxidized." "hippuric acid, cinnamic acid, betaine, creatine, alanine, phenylalanine, valine, leucine, asparaginic acid, asparagine, glutaminic acid, serine, hydroxyproline, taurine, ... HO groups in alcohols and HO acids"

{Includes other ***!!!!*** excellent links on effects on chemistry body}

Sodium Chlorate, etc

{A number of statements in this document need verification. Author has non-traditional background.} "The use of a family of chemical agents, releasing active species of oxygen, effective against infectious microorganisms and viruses is described with emphasis on Chlorine Dioxide (CLO2), one of the oxides of chlorine. " "Explanation of the biochemical mechanisms of acid of CLO2 as an anti-microbial agent, is presented. Particular attention is given to Candida albicans, cytomegalovirus, polio virus, Herpes I and II, HTLV-III and Pseudomonas responding to the clinical application of CLO2. It is implied that these biochemical mechanisms are so fundamental that the development of resistant strains of bacteria and/or yeast would not occur with other anti-infectious agents. Limited lists of health abnormalities that respond to CLO2 are discussed."