Sarcoma research Kylllie.Smith-Fry@hci.utah.edu ~Kind animal care tech

Kevin B. Jones, MD Leader, Huntsman Cancer Institute Sarcoma Disease Center Division Chief, Sarcoma, Department of Orthopaedics Professor, Department of Orthopaedics and Adjunct Professor of Oncological Sciences As an orthopaedic surgeon specialized in the care of pediatric and adult patients with sarcoma, I see first-hand the limitations and frank failures of the currently available treatment options. Not only do we fail to cure far too many young patients with sarcomas, but the long-term effects of our treatments create other major challenges to the health of the survivors in the long term. With protected time for basic investigation, I dedicate my entire laboratory to the study of pediatric and young adult fusion oncogene-associated sarcomas. In efforts always angling toward improved targeted therapies, we use mouse genetic models of sarcomagenesis to dissect pathways of importance to initiation and progression of tumors. This work utilizes conditional activation of translocation-associated fusion oncogenes as well as manipulation of additional modifying genes directed toward improved understanding of the conditions that promote or inhibit sarcomagenesis. This work has led to generous experience with comparative genomics and epigenomics. The simple genetic changes that drive translocation-associated sarcomas make a strong argument for cancer being defined as a transcriptional state for cells, rather than a state of accumulated mutations or genetic losses and gains. The study of the epigenetic determinants of this transcriptional state in cells that harbor very few genetic code alterations has already revealed important knowledge that pertains to more complex genome cancer types as well as to transcriptional biology more generally. I also believe firmly in the synergy possible in collaborative team science. Such efforts are required for progress toward improved treatments for rare malignancies that can never be studied with optimal efficacy in a silo. With such collaborative work as direct goal, I have participated in and assembled teams to work on pediatric sarcomas both within my institution and internationally.

Tumor research

Osteosarcoma, NOS is a malignant tumor in which the cells synthesize bone; it is the most common primary malignant solid tumor of bone (plasma cell myeloma is actually the most common primary bone tumor but it's not a solid tumor)

Background Reports of osteoblastic tumours are limited to a few case reports in veterinary medicine. Osteoblastoma-like osteosarcoma has been accepted by the World Health Organization as an intermediate form between an osteosarcoma and osteoblastoma. This type of tumour indicates an osteosarcoma, that may resemble osteoblastoma clinically, histologically, and radiologically and have the capability for metastasis. Osteoblastoma-like osteosarcoma has not been described in veterinary medicine so far. Case presentation An eight-year old cat was presented due to progressive ataxia and paraparesis of the pelvic limbs. Imaging confirmed a well-defined, extradural mass originating from the spinous process of the second thoracic vertebra (T2) leading to severe compression of the spinal cord. Decompressive cytoreduction was achieved by removal of the mass after dorsal laminectomy of T1. After recovering from an acute worsening 3.5 weeks after surgery, the cat had an improved neurological status and the dorsal compression was resolved at follow-up 8 months later. A focal contrast enhancing lesion was still evident at the base of T2 spinous process and lung metastasis was additionally suspected. Based on histopathological, radiographic, and clinical features, an “osteoblastoma-like osteosarcoma” was suspected. Conclusions To the best of our knowledge, this is the first description of this tumour in veterinary medicine. In addition, this case report highlights the difficulty in the diagnosis and definition of osseous neoplasia in cats and provides a literature review.

Osteoblastoma-like osteosarcoma is a rare form of osteosarcoma that shares similar clinical and pathological characteristics with osteoblastoma. We describe a 12-year-old boy with osteoblastoma-like osteosarcoma of the cuboid and skull without lung involvement. Despite inadequate primary surgical tr …

Osteoblastoma is an uncommon benign bone-forming neoplasm that accounts for about 1% of all primary bone tumors and 1 to 5 % of all benign bone tumors, and 10% of all osseous spinal neoplasms.[1][2][3] Historically it was referred to as giant osteoid osteoma highlighting its histopathologic similarities to osteoid osteoma.[4] In fact, some authors consider the entities to be variant expressions of the same pathologic process; however, the prevailing opinion is that they are distinct pathologic entities with varying clinical presentations. Osteoblastoma commonly arises in the posterior elements of the spine and the sacrum (approximately 30 to 40%).[5] Other common locations include the mandible (referred to as cementoblastoma) and long tubular bones (lower upper extremities), where it is usually observed in the metadiaphysis.[4] An accurate diagnosis of osteoblastoma is critical in determining the appropriate treatment modality and prognosis.[6]

The Classroom gives an overview of the info you need to raise chickens, manage the coop, keep them healthy and safe, and understand breeding.

Enrichment is widely used as tool for managing fearfulness, undesirable behaviors, and stress in captive animals, and for studying exploration and personality. Inconsistencies in previous studies of physiological and behavioral responses to enrichment led us to hypothesize that enrichment and its removal are stressful environmental changes to which the hormone corticosterone and fearfulness, activity, and exploration behaviors ought to be sensitive. We conducted two experiments with a captive population of wild-caught Clark's nutcrackers (Nucifraga columbiana) to assess responses to short- (10-d) and long-term (3-mo) enrichment, their removal, and the influence of novelty, within the same animal. Variation in an integrated measure of corticosterone from feathers, combined with video recordings of behaviors, suggests that how individuals perceive enrichment and its removal depends on the duration of exposure. Short- and long-term enrichment elicited different physiological responses, with the former acting as a stressor and birds exhibiting acclimation to the latter. Non-novel enrichment evoked the strongest corticosterone responses of all the treatments, suggesting that the second exposure to the same objects acted as a physiological cue, and that acclimation was overridden by negative past experience. Birds showed weak behavioral responses that were not related to corticosterone. By demonstrating that an integrated measure of glucocorticoid physiology varies significantly with changes to enrichment in the absence of agonistic interactions, our study sheds light on potential mechanisms driving physiological and behavioral responses to environmental change.

Aflatoxicosis is a type of poisoning from ingestion of aflatoxins in contaminated foods or poultry feed. They are potent hepatotoxins produced by Aspergillus flavus, A. parasiticus, or Penicillium puberulum. The 4 aflatoxins of concern are B1, B2, G1, and G2. However, B1 is the most predominant and toxic.

PARASITICIDES (antiparasitics) for veterinary use in LIVESTOCK - cattle, sheep, goats, pig, poultry - HORSES, DOGS and CATS, parasiticidal drugs, antiparasitic drugs, antiparasitics, insecticides, tickicides, louisicides, larvicides, scabicides, acaricides, nematicides, taenicides, flukicides,

November 19 – 20, 2024

Learn about the veterinary topic of Antimicrobial Use in Animals. Find specific details on this topic and related topics from the Merck Vet Manual.

Cephalosporins - Learn about the causes, symptoms, diagnosis & treatment from the Merck Manuals - Medical Consumer Version.

Overview of Antibiotics - Learn about the causes, symptoms, diagnosis & treatment from the Merck Manuals - Medical Consumer Version.

Three weeks after confirming the diagnosis of crusted scabies on an HIV-positive patient, I started to scratch while driving in the parking lot at Cooper University Hospital. I didn’t give it much thought until the next day, when this stinging-itching sensation wouldn’t relent (interestingly the scratching felt soooo gooood). I realized that I probably had acquired scabies.

Basic Facts Riley and Little--large fowl Ameraucana hens. 1 1/2 yrs old. Smallish normally, and EXTREMELY underweight recently. Sunny—Riley and Little’s father. 2 1/2 years. Normal size. Good weight. Sunny and his mate (mother of Riley & Little) are from 1 breeder and are possibly full brother...

My BYC post: Oh the salts- salts aren't used to curb diarrhea - they actually create it. It's used as a flush in **extreme** cases to flush absolutely everything out of the bird's system. (In other animals, and humans, it's an emetic - causes vomiting for the same reason - to expel everything from the...

How To Incise and Drain an Abscess - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical Professional Version.

You will learn about bird leg anatomy with a labeled diagram. Get details of bones, muscles, sciatic nerves, and more from the birds legs.

An I&D or Incision and Drainage and performed to drain purulent fluid (aka pus) from a fluid collection called an abscess.

This comprehensive database from Drugs.com contains treatment options for Chickens Ab - AV Index and a variety of animals including pets, livestock and numerous exotic species.

Scaly leg and face mites; Scaley leg mites; and Depluming mites. When the feet are involved, lameness may be seen in advanced cases because of ankylosis of the hock and other joints, necrosis and sloughing of toes, swollen nail beds, and twisted nails Ivermectin may be toxic if given intramuscularly. ivermectin will precipitate if mixed with water. // A water-soluble, 10-mg/ml liquid ivermectin Moxidectin is another option.

Vitamin A is critical for differentiation of epithelial cells into cuboidal, columnar, or mucous-producing cells. Hypovitaminosis A, causes epithelial metaplasia and hyperkeratosi

Mange is commonly seen in animals, but humans can develop this skin condition as well.