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Osteoblastoma-like osteosarcoma is a rare form of osteosarcoma that shares similar clinical and pathological characteristics with osteoblastoma. We describe a 12-year-old boy with osteoblastoma-like osteosarcoma of the cuboid and skull without lung involvement. Despite inadequate primary surgical tr …

We report an osteoblastoma-like osteosarcoma in the right proximal fibula in a 22-year-old woman. Radiographs showed an irregular osteolytic lesion from the metaphysis to the epiphysis in the proximal fibula with partial destruction of cortical bone. Tissue from a biopsy indicated a typical osteoblastoma. Curettage and bone graft was performed. One year after the surgery, local recurrence occurred, and a wide excision was performed. Histological examination of the en-bloc surgical specimen revealed the tumor had permeated through the host bony trabeculae, although the nuclear atypia was not marked. Immunohistochemical expression of MIB-1 was detected in 9.0% of cells.

Modern Pathology - Methylation and copy number profiling: emerging tools to differentiate osteoblastoma from malignant mimics?

A series of 11 osteosarcomas that histologically resembles osteoblastoma was reviewed. The ages of the seven males and four females ranged from 19 to 47 yr (average 29). In six patients the roentgenograms showed cortical destruction and poorly defined borders on the lesion; this roentgenographic pre …

With the important limitation of a small cohort of patients, the presence of areas of conventional (high-grade) osteosarcoma is the only parameter to predict the aggressiveness of osteoblastoma-like osteosarcoma.

Aggressive osteoblastoma (AO) is a rare variant of osteoblastoma characterized histologically by epithelioid osteoblasts and clinically by local recurrences if not excised completely. Aggressive osteoblastoma has been described in various unusual sites; however, based on our search of the literature …

Osteoblastoma is an uncommon benign bone-forming neoplasm that accounts for about 1% of all primary bone tumors and 1 to 5 % of all benign bone tumors, and 10% of all osseous spinal neoplasms.[1][2][3] Historically it was referred to as giant osteoid osteoma highlighting its histopathologic similarities to osteoid osteoma.[4] In fact, some authors consider the entities to be variant expressions of the same pathologic process; however, the prevailing opinion is that they are distinct pathologic entities with varying clinical presentations. Osteoblastoma commonly arises in the posterior elements of the spine and the sacrum (approximately 30 to 40%).[5] Other common locations include the mandible (referred to as cementoblastoma) and long tubular bones (lower upper extremities), where it is usually observed in the metadiaphysis.[4] An accurate diagnosis of osteoblastoma is critical in determining the appropriate treatment modality and prognosis.[6]

10.1055/b-0034-87942 Periosteal Reaction The periosteum is a membrane that covers the majority of bone except at locations at and near cartilage. How periosteum responds to stimuli (e.g., trauma, i…

Osteosarcoma is the most common bone cancer in adolescents and young adults, but it is a rare cancer with no improvement in patient survival in the last four decades. The main problem of this bone tumor is its evolution toward lung metastatic ...

[This article contains very loose assumptions]

Slipped tendon?

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The Classroom gives an overview of the info you need to raise chickens, manage the coop, keep them healthy and safe, and understand breeding.

Raptor Enrichment Ideas, Planning, Inspriation

Want to keep your bird happy and engaged? Check out these 6 fun and simple avian enrichment tips to boost your bird’s mental and physical health. Read the full post now!

Enrichment is widely used as tool for managing fearfulness, undesirable behaviors, and stress in captive animals, and for studying exploration and personality. Inconsistencies in previous studies of physiological and behavioral responses to enrichment led us to hypothesize that enrichment and its removal are stressful environmental changes to which the hormone corticosterone and fearfulness, activity, and exploration behaviors ought to be sensitive. We conducted two experiments with a captive population of wild-caught Clark's nutcrackers (Nucifraga columbiana) to assess responses to short- (10-d) and long-term (3-mo) enrichment, their removal, and the influence of novelty, within the same animal. Variation in an integrated measure of corticosterone from feathers, combined with video recordings of behaviors, suggests that how individuals perceive enrichment and its removal depends on the duration of exposure. Short- and long-term enrichment elicited different physiological responses, with the former acting as a stressor and birds exhibiting acclimation to the latter. Non-novel enrichment evoked the strongest corticosterone responses of all the treatments, suggesting that the second exposure to the same objects acted as a physiological cue, and that acclimation was overridden by negative past experience. Birds showed weak behavioral responses that were not related to corticosterone. By demonstrating that an integrated measure of glucocorticoid physiology varies significantly with changes to enrichment in the absence of agonistic interactions, our study sheds light on potential mechanisms driving physiological and behavioral responses to environmental change.

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Aflatoxicosis is a type of poisoning from ingestion of aflatoxins in contaminated foods or poultry feed. They are potent hepatotoxins produced by Aspergillus flavus, A. parasiticus, or Penicillium puberulum. The 4 aflatoxins of concern are B1, B2, G1, and G2. However, B1 is the most predominant and toxic.

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