COVID-19 & other Diseases

Illustration by Luis G. Rendon/The Daily BeastYou might not know it by looking around you at all those unmasked faces, but there’s still an awful lot of novel coronavirus out there. And the virus appears to be mutating faster th0an ever, producing steadily more contagious variants and subvariants.The evolutionary trend with SARS-CoV-2 might not mean there are definitely going to be big surges in infections, hospitalizations and deaths. At least not everywhere or for very long.But it underscores a

Vaccines against infectious bronchitis of chickens (Gallus gallus domesticus) have arguably been the most successful, and certainly the most widely used, of vaccines for diseases caused by coronaviruses, the others being against bovine, canine, feline ...

The SARS-Cov-2 pandemic that currently affects the entire world has been shown to be especially dangerous in the elderly (≥65 years) and in smokers, with notably strong comorbidity in patients already suffering from chronic diseases, such as Type 2 diabetes, cancers, chronic respiratory diseases, ob …

A nationwide survey by the Food and Drug Administration (FDA) suggests that risk factors for foodborne disease, such as inadequate handwashing by workers and keeping food at unsafe temperatures, are very common in the nation's restaurants, retail stores, and institutional food services.

****!!!!**** "an important role of SOD3 in protecting against the cytokine storm"

"This document was drafted to help answer many FAQ’s and to clarify a few facts regarding the role of the CDC, EPA, and FDA as it relates to disinfectants and hand sanitizers used to fight COVID-19."

"These studies are inconsistent and do not give clear evidence as to whether there is an association between the temperature, humidity, and virus transmission, and the global view seems to give a clearer conclusion; all the three studies that conducted analysis at the global level found an association between higher humidity, warmer temperatures, and lower transmission rate (10). However, climate-dependent epidemic modeling suggested that the absence of population immunity is a much stronger factor in viral transmission and that summer weather will not substantially limit the spread of the COVID-19 pandemic"

"This study reveals the leading role of airborne SARS-CoV-2 transmission and negligible role of fomite transmission in a poorly ventilated indoor environment, highlighting the need for more targeted interventions in such environments. The quanta generation rate of the index case differed by a factor of 1.8 on the two buses and transmission occurred in the afternoon of the same day, indicating a time-varying effective viral load within a short period of five hours."

The recently emerged coronavirus pandemic (COVID-19) has become a worldwide threat affecting millions of people, causing respiratory system related problems that can end up with extremely serious consequences. As the infection rate rises significantly ...

(2006) "February 2003, a severe acute respiratory syndrome coronavirus (SARS-CoV)"

"support the necessity to wear surgical masks during the COVID-19 pandemics; "

Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative pathogen of the COVID-19 pandemic, exerts a massive health and socioeconomic crisis. The virus infects alveolar epithelial type 2 cells (AT2s), leading to lung injury and impaired gas exchange, but the mech …

BU researchers, discovering the full extent of molecular activities triggered inside lung cells by COVID-19 infection, say there are at least 18 existing, FDA-approved drugs that could potentially be repurposed to combat COVID-19.

****!!!!****!!!!**

"The consumption pattern characterized by high consumption of vegetables, fruit, fish, olive oil and red wine has been associated with improvements in the total antioxidant capacity of individuals and reduced incidence of diseases related to oxidation. Also, high body iron levels may contribute to increase the oxidative stress by the generation of reactive oxygen species. "

Summary: High-affinity iron acquisition is mediated by siderophore-dependent pathways in the majority of pathogenic and nonpathogenic bacteria and fungi. Considerable progress has been made in characterizing and understanding mechanisms of siderophore ...

Mucormycosis, most commonly caused by Rhizopus oryzae, is a life-threatening infection that occurs in patients immunocompromised by diabetic ketoacidosis (DKA),...

What is oxidative stress, and why does it matter? We explain how this imbalance affects your body and ways to prevent it.

Abstract. Fungi of the basal lineage order Mucorales are able to cause infections in animals and humans. Mucormycosis is a well-known, life-threatening disease

"a retrospective review of outcomes in patients with rhino-orbital-cerebral mucormycosis suggested that combination therapy with lipid polyene plus caspofungin was superior to monotherapy with lipid polyenes" "patients with elevated levels of available serum iron are uniquely susceptible to infection by R. oryzae and other Zygomycetes, but not to other pathogenic fungi, such as Candida or Aspergillus"

"these observations provide novel insight into the unique susceptibility of patients with DKA to mucormycosis and could provide a foundation for novel therapeutic interventions." "the emergence of mucormycosis in patients with hematologic malignancies who are receiving voriconazole prophylaxis"

"Among the more recent therapeutic developments in mucormycosis treatment are: the lipid formulations of amphotericin B, which are now the drugs of choice; the new triazole posaconazole, with promising efficacy as salvage treatment; the iron chelators deferasirox and deferiprone; the echinocandins in combination with amphotericin B (AmB) and recombinant growth factors such as granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF)."

Background Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter is related to increased mortality in COVID-19. Still, it is not clear if iron dysmetabolism is mechanistically linked to COVID-19 pathobiology" "Alterations of iron homeostasis can persist for at least two months after the onset of COVID-19 and are closely associated with non-resolving lung pathologies and impaired physical performance. Determination of serum iron parameters may thus be a easy to access measure to monitor the resolution of COVID-19."