COVID-19 & other Diseases

COVID-19 & other Diseases

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Nightmare COVID Variants Are Cracking the Code to Our Immunity
Nightmare COVID Variants Are Cracking the Code to Our Immunity
Illustration by Luis G. Rendon/The Daily BeastYou might not know it by looking around you at all those unmasked faces, but there’s still an awful lot of novel coronavirus out there. And the virus appears to be mutating faster th0an ever, producing steadily more contagious variants and subvariants.The evolutionary trend with SARS-CoV-2 might not mean there are definitely going to be big surges in infections, hospitalizations and deaths. At least not everywhere or for very long.But it underscores a
·news.yahoo.com·
Nightmare COVID Variants Are Cracking the Code to Our Immunity
Severe acute respiratory syndrome vaccine development: experiences of vaccination against avian infectious bronchitis coronavirus
Severe acute respiratory syndrome vaccine development: experiences of vaccination against avian infectious bronchitis coronavirus
Vaccines against infectious bronchitis of chickens (Gallus gallus domesticus) have arguably been the most successful, and certainly the most widely used, of vaccines for diseases caused by coronaviruses, the others being against bovine, canine, feline ...
·ncbi.nlm.nih.gov·
Severe acute respiratory syndrome vaccine development: experiences of vaccination against avian infectious bronchitis coronavirus
Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19 - PubMed
Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19 - PubMed
The SARS-Cov-2 pandemic that currently affects the entire world has been shown to be especially dangerous in the elderly (≥65 years) and in smokers, with notably strong comorbidity in patients already suffering from chronic diseases, such as Type 2 diabetes, cancers, chronic respiratory diseases, ob …
·pubmed.ncbi.nlm.nih.gov·
Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19 - PubMed
Disease hazards common in food operations, FDA says
Disease hazards common in food operations, FDA says
A nationwide survey by the Food and Drug Administration (FDA) suggests that risk factors for foodborne disease, such as inadequate handwashing by workers and keeping food at unsafe temperatures, are very common in the nation's restaurants, retail stores, and institutional food services.
·cidrap.umn.edu·
Disease hazards common in food operations, FDA says
Effects of Environmental Factors on Severity and Mortality of COVID-19
Effects of Environmental Factors on Severity and Mortality of COVID-19
"These studies are inconsistent and do not give clear evidence as to whether there is an association between the temperature, humidity, and virus transmission, and the global view seems to give a clearer conclusion; all the three studies that conducted analysis at the global level found an association between higher humidity, warmer temperatures, and lower transmission rate (10). However, climate-dependent epidemic modeling suggested that the absence of population immunity is a much stronger factor in viral transmission and that summer weather will not substantially limit the spread of the COVID-19 pandemic"
·frontiersin.org·
Effects of Environmental Factors on Severity and Mortality of COVID-19
Predominant airborne transmission and insignificant fomite transmission of SARS-CoV-2 in a two-bus COVID-19 outbreak originating from the same pre-symptomatic index case
Predominant airborne transmission and insignificant fomite transmission of SARS-CoV-2 in a two-bus COVID-19 outbreak originating from the same pre-symptomatic index case
"This study reveals the leading role of airborne SARS-CoV-2 transmission and negligible role of fomite transmission in a poorly ventilated indoor environment, highlighting the need for more targeted interventions in such environments. The quanta generation rate of the index case differed by a factor of 1.8 on the two buses and transmission occurred in the afternoon of the same day, indicating a time-varying effective viral load within a short period of five hours."
·ncbi.nlm.nih.gov·
Predominant airborne transmission and insignificant fomite transmission of SARS-CoV-2 in a two-bus COVID-19 outbreak originating from the same pre-symptomatic index case
Surface interactions and viability of coronaviruses
Surface interactions and viability of coronaviruses
The recently emerged coronavirus pandemic (COVID-19) has become a worldwide threat affecting millions of people, causing respiratory system related problems that can end up with extremely serious consequences. As the infection rate rises significantly ...
·ncbi.nlm.nih.gov·
Surface interactions and viability of coronaviruses
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 - PubMed
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 - PubMed
Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative pathogen of the COVID-19 pandemic, exerts a massive health and socioeconomic crisis. The virus infects alveolar epithelial type 2 cells (AT2s), leading to lung injury and impaired gas exchange, but the mech …
·pubmed.ncbi.nlm.nih.gov·
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 - PubMed
How Coronavirus Damages Lung Cells within Mere Hours
How Coronavirus Damages Lung Cells within Mere Hours
BU researchers, discovering the full extent of molecular activities triggered inside lung cells by COVID-19 infection, say there are at least 18 existing, FDA-approved drugs that could potentially be repurposed to combat COVID-19.
·bu.edu·
How Coronavirus Damages Lung Cells within Mere Hours
Diet, iron biomarkers and oxidative stress in a representative sample of Mediterranean population - Nutrition Journal
Diet, iron biomarkers and oxidative stress in a representative sample of Mediterranean population - Nutrition Journal
"The consumption pattern characterized by high consumption of vegetables, fruit, fish, olive oil and red wine has been associated with improvements in the total antioxidant capacity of individuals and reduced incidence of diseases related to oxidation. Also, high body iron levels may contribute to increase the oxidative stress by the generation of reactive oxygen species. "
·nutritionj.biomedcentral.com·
Diet, iron biomarkers and oxidative stress in a representative sample of Mediterranean population - Nutrition Journal
Siderophore-Based Iron Acquisition and Pathogen Control
Siderophore-Based Iron Acquisition and Pathogen Control
Summary: High-affinity iron acquisition is mediated by siderophore-dependent pathways in the majority of pathogenic and nonpathogenic bacteria and fungi. Considerable progress has been made in characterizing and understanding mechanisms of siderophore ...
·ncbi.nlm.nih.gov·
Siderophore-Based Iron Acquisition and Pathogen Control
Iron Uptake and Mucormycosis Pathogenesis
Iron Uptake and Mucormycosis Pathogenesis
Mucormycosis, most commonly caused by Rhizopus oryzae, is a life-threatening infection that occurs in patients immunocompromised by diabetic ketoacidosis (DKA),...
·grantome.com·
Iron Uptake and Mucormycosis Pathogenesis
Iron Acquisition: A Novel Prospective on Mucormycosis Pathogenesis and Treatment
Iron Acquisition: A Novel Prospective on Mucormycosis Pathogenesis and Treatment
"a retrospective review of outcomes in patients with rhino-orbital-cerebral mucormycosis suggested that combination therapy with lipid polyene plus caspofungin was superior to monotherapy with lipid polyenes" "patients with elevated levels of available serum iron are uniquely susceptible to infection by R. oryzae and other Zygomycetes, but not to other pathogenic fungi, such as Candida or Aspergillus"
·ncbi.nlm.nih.gov·
Iron Acquisition: A Novel Prospective on Mucormycosis Pathogenesis and Treatment
Pathogenesis of Mucormycosis
Pathogenesis of Mucormycosis
"these observations provide novel insight into the unique susceptibility of patients with DKA to mucormycosis and could provide a foundation for novel therapeutic interventions." "the emergence of mucormycosis in patients with hematologic malignancies who are receiving voriconazole prophylaxis"
·ncbi.nlm.nih.gov·
Pathogenesis of Mucormycosis
Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3) | Haematologica
Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3) | Haematologica
"Among the more recent therapeutic developments in mucormycosis treatment are: the lipid formulations of amphotericin B, which are now the drugs of choice; the new triazole posaconazole, with promising efficacy as salvage treatment; the iron chelators deferasirox and deferiprone; the echinocandins in combination with amphotericin B (AmB) and recombinant growth factors such as granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF)."
·haematologica.org·
Diagnosis and treatment of mucormycosis in patients with hematological malignancies: guidelines from the 3rd European Conference on Infections in Leukemia (ECIL 3) | Haematologica
Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study - Respiratory Research
Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study - Respiratory Research
Background Severe coronavirus disease 2019 (COVID-19) is frequently associated with hyperinflammation and hyperferritinemia. The latter is related to increased mortality in COVID-19. Still, it is not clear if iron dysmetabolism is mechanistically linked to COVID-19 pathobiology" "Alterations of iron homeostasis can persist for at least two months after the onset of COVID-19 and are closely associated with non-resolving lung pathologies and impaired physical performance. Determination of serum iron parameters may thus be a easy to access measure to monitor the resolution of COVID-19."
·respiratory-research.biomedcentral.com·
Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study - Respiratory Research