Streptococcus pneumoniae in the nasal cavity of mice causes lower respiratory tract infection after airway obstruction - PubMed

COVID & other Diseases
Nasal Colonization with Streptococcus pneumoniae Includes Subpopulations of Surface and Invasive Pneumococci
We demonstrated that during colonization with Streptococcus pneumoniae the nasal mucosal tissues of mice support two populations of pneumococci. Transparent-phase pneumococci can be readily washed from the outer surface, while a second population composed ...
Infection Control Today website articles
{Current COVID-19 related developments and news}
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus
A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies revealed a recurrent pattern of G614 increase at multiple geographic levels: national, ...
Subtle differences in virus composition affect disinfection kinetics and mechanisms - PubMed
****!!!!*** "Chlorine Dioxide caused great variability in the inactivation kinetics between viruses and was the only treatment that did not induce genome damage... ClO2 rapidly degraded the capsid proteins of all three viruses. Protein composition alone could not explain the observed degradation trends; instead, molecular dynamics simulations indicated that degradation is dictated by the solvent-accessible surface area of individual amino acids. Finally, despite the similarities of the three viruses investigated, *****their mode of inactivation by a single disinfectant varied. This explains why closely related viruses can exhibit drastically different inactivation kinetics."
Inactivation of influenza virus haemagglutinin by chlorine dioxide: oxidation of the conserved tryptophan 153 residue in the receptor-binding site | Microbiology Society
2012. by Norio Ogata. Airborne influenza virus infection of mice can be prevented by gaseous chlorine dioxide (ClO2). This study demonstrated that ClO2 abolished the function of the haemagglutinin (HA) of influenza A virus (H1N1) in a concentration-, time- and temperature-dependent manner. The IC50 during a 2 min reaction with ClO2 at 25 °C was 13.7 µM, and the half-life time of HA with 100 µM ClO2 at 25 °C was 19.5 s. Peptides generated from a tryptic digest of ClO2-treated virus were analysed by mass spectrometry. An HA fragment, 150NLLWLTGK157 was identified in which the tryptophan residue (W153) was 32 mass ...
Inhibition of the Binding of Spike Protein of SARS-CoV-2 Coronavirus to Human Angiotensin-Converting Enzyme 2 by Chlorine Dioxide
************** by Norio Ogata
Ventilator-associated tracheobronchitis: the impact of targeted antibiotic therapy on patient outcomes - PubMed
Nosocomial lower respiratory tract infections are a common cause of morbidity and mortality in ICU patients receiving mechanical ventilation. Many studies have investigated the management and prevention of ventilator-associated pneumonia (VAP), but few have focused on the role of ventilator-associat …
EPICOS, the pioneering study that seeks to protect healthcare workers against covid-19
Coronavirus (COVID-19): The latest science & expert commentary | Frontiersin.org
Trusted source for the latest science on SARS-CoV-2 & COVID-19
Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment | ACS Medicinal Chemistry Letters
While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant metabolite reaching the lungs. With its synthetic simplicity and in vivo efficacy in the veterinary setting, we contend that GS-441524 is superior to remdesivir for Covid-19 treatment.
COVID-19 and therapy with essential oils having antiviral, anti-inflammatory, and immunomodulatory properties
{Explanation of dynamics in lungs}
COVID-19: We may already have treatments for lungs of ‘Jell-O’ | Healthing.ca
The 'bradykinin hypothesis': Biologist discovers what leads to the devastating effects of COVID-19 — and the potential fix.
{COVID-19 articles} Coronavirus Highlights Urgent Need for Science-Backed Research ~Mary Ann Liebert, Inc., publishers
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in the most promising areas of biotechnology and regenerative medicine, biomedical research, clinical medicine and surgery, technology and engineering, law, integrative medicine, public health, and environmental studies.
Texas A&M Responds: COVID-19 - Texas A&M Today
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Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury - PubMed
{Note: Minks are theorized to be susceptible to coronavirus because of having ACE2.}
COVID-19 and Animals | CDC
CDC provides credible COVID-19 health information to the U.S.
Research Index for COVID-19 — TAMU Division of Research
**** {Studies currently in progress}
SARS-CoV-2 viability under different meteorological conditions, surfaces, fluids and transmission between animals
"Mice are not susceptible to SARS-CoV-2 infection and are, therefore, not suitable as research models" "SARS-CoV-2 can persist differently according to the surface, from hours to days (SARS-CoV-2 viability varies from hours to days depending on the surface), but infection only occurs when touching mucus membranes after contact with these contaminated surfaces. SARS-CoV-2 can also persist in air droplets for an uncertain period of time that could be longer if the virus is attached to pollution particles. Wastewater and tap water could act as SARS-CoV-2 propagation tools since positive samples of SARS-CoV-2 have been found in water samples in different countries worldwide." "All SARS viruses could be inactivated within 30 min at 20 °C with more than 0.5 mg/L residual free chlorine or 2.19 mg/L residual chlorine dioxide remaining"
Disinfectant-Fact-Sheet.pdf
Table ranks microorganisms in order of susceptibility to the various levels of disinfectants. Includes some Chlorine Dioxide info
Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques - ScienceDirect
The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world. Clinical features that drive SARS-CoV-2 pathogenesis in human…
Air, Surface Environmental, and Personal Protective Equipment (PPE) Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient
This study documents results of SARS-CoV-2 polymerase chain reaction (PCR) testing of environmental surfaces and personal protective equipment surrounding 3 COVID-19 patients in isolation rooms in a Singapore hospital.
Coronavirus Resource Center - Harvard Health
The rapid spread of the virus that causes COVID-19 continues to spark alarm worldwide. Countries around the world are grappling with surges in confirmed cases, hospitalizations, and deaths. Calls for preventive measures such as social distancing and ...
How Coronavirus Spreads ~CDC
SARS-CoV-2 in environmental perspective: Occurrence, persistence, surveillance, inactivation and challenges
**SARS-CoV {NOT SARS-CoV-2} showed inactivation with chlorine (10 mg/L for 10 min –free residue chlorine of 0.4 mg/L) and chlorine dioxide (40 mg/L for 30 min –free residue chlorine of 2.19 mg/L
CAS COVID-19 Resources ~Chemical Abstracts Service, American Chemical Society
As a specialist in scientific information solutions, CAS is partnering with research organizations around the globe to tackle the rapidly evolving and complex challenge of COVID-19. Aligned with our mission as a division of the American Chemical Society, CAS is making a wide range of resources and expertise openly available to support this fight. If customized support from CAS scientists and technologists would be valuable to augment your COVID-19 research efforts, we welcome your outreach to the CAS Customer Center.
WHO breaks down more myths about COVID-19
Search results for "COVID" in preprints, etc ~Biorxiv
The latest on the coronavirus
Harvard Chan School experts offer comments and context about the coronavirus in a variety of media outlets.
A Letter about the Airborne Transmission of SARS-CoV-2 Based on the Current Evidence - Aerosol and Air Quality Research
ABSTRACT
World Health Organization has suggested that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted through person-to-person transmission and contact with contaminated surfaces. However, rapid spread of the coronavirus disease 2019 (COVID-19) suggests other routes such as airborne transmission may be involved. A few research studies have been conducted to evaluate the potential transmission of this virus through air. Although some studies have found no evidence of airborne transmission, other more recent work is proving the presence of SARS-CoV-2 even in public places. Also, the past experiences and knowledge about the mechanisms of similar viruses such as SARS-CoV support this hypothesis. It seems that the best decision at the moment is to follow a conservative approach, and accept the hypothesis that SARS-CoV-2 is able to be transmitted through air. By this, control measures could be employed to prevent further COVID-19 infection.