Diseases

Hyperuricemia is defined as an elevated serum uric acid level, usually greater than 6 mg/dL in women and 7 mg/dL in men. Elevated serum uric acid is present in an estimated 38 million Americans, and the incidence is increasing worldwide as developing countries adopt more Western diets and lifestyles. Most people with this condition will not have obvious clinical manifestations, however, it is unclear what the long-term effects of hyperuricemia are on overall cardiovascular health, renal function, and overall morbidity.[1] Hyperuricemia results from increased uric acid production, decreased excretion, or a combination of both processes.

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Learn about risk factors and common causes of health conditions. Search medical conditions and chronic diseases from A to Z.

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Ventral rectopexy has gained popularity in Europe to treat full-thickness rectal external and internal prolapse. This procedure has been shown to achieve acceptable anatomic results with low recurrence rates, few complications, and improvements of ...

Hirsutism causes excess hair growth. It affects women and people assigned female at birth. It doesn’t have a known cause, but it’s a symptom of PCOS. It’s treatable.

PCOS is a common type of hormone imbalance in people assigned female at birth. It can cause irregular periods, weight gain, infertility, acne and excess hair growth.

Conclusion. When excessive height loss occurs in the elderly, which may be indicated by a cervical-bent posture, examination of the head and neck should be performed to detect common carotid artery (CCA) and internal carotid artery (ICA) aberration. ...

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Parkinson’s disease (PD) is the most common movement disorder in the world, affecting 1–2 per 1,000 of the population. The main pathological changes of PD are damage of dopaminergic neurons in substantia nigra of the central nervous system and ...

Abstract This chapter describes primary and secondary bone tumors affecting the skull base and provides important epidemiologic and imaging clues for the differential diagnosis. Except for bone met…

25% of Americans with diabetes also have anemia. There is a relationship between the two diseases. The risk of developing anemia with diabetes increases with age.

Not all chest pains are symptoms of a heart attack. Learn which symptoms could signal trouble and which are probably something else.

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European Journal of Human Genetics - Marfan syndrome: clinical diagnosis and management

Marfan syndrome (MFS) is a rare inherited autosomic disorder, which encompasses a variety of systemic manifestations caused by mutations in the Fibrillin-1 encoding gene (FBN1). Cardinal clinical phenotypes of MFS are highly variable in terms of severity, ...

"It's being misunderstood and left out."

Anyone can develop spondylolisthesis but it more commonly affects people with Marfan syndrome. An additional chara...

It’s difficult to detect — the first diagnosis is often made in a morgue. Its roots are defective genes. Its victims are usually tall and lanky with long and supple fingers. They’…

The world’s undiagnosed Marfan patients often go through life unaware of the hidden killer lurking in their DNA – a gene variant which may lead to sudden death at any moment via an aortic dissection. Currently, there is no therapy available to counteract this disastrous aortic event, so patient awareness of their condition is key to prevention. To learn more about Marfan syndrome and improve diagnosis, our project needs patients to enroll online in our research cohort. In this way, patients can themselves help us contribute to new therapies and averting sudden deaths.

A congenital connective tissue disorder that confers pro basketball height also permanently benches an NBA prospect’s dreams of joining the league

Dr. Ryan Goodwin, Director, Cleveland Clinic Center for Pediatric Orthopaedics and Scoliosis Surgery is joined by physical therapists Raquel Griffis, PT, DPT and Lisa Seely, PT to discuss the changes that occur to the musculoskeletal system with Marfan Syndrome, treatment options, when to seek a physical therapist (PT), how to work with a PT, and a case presentation of a child with Marfan. Filmed at the Regional Symposium on Marfan Syndrome and Related Disorders presented by Cleveland Clinic and The Marfan Foundation

High arterial tortuosity may signify early arterial pathology which may precede development of intracranial aneurysms. We measured arterial tortuosity of intracranial vessels and reviewed the medical records of three groups of patients: with intracranial ...

The tortuosity index of intracranial arteries is an easily calculated and highly reproducible measure, which shows a high specificity for Marfan syndrome and Loeys-Dietz syndrome and may be useful in differentiating these 2 entities.

There is a general assumption in the cerebrovascular literature that there is an association between carotid artery tortuosity and connective tissues disease; however, this has not been firmly established. The purpose of this study was to determine the ...

kidney cysts seems to be linked to an increased aortic dissection risk,,,

According to this study the drug Irbesartan reduces aortic dilatation in children and young adults with Marfan syndrome.