{Related to Predictive Models and Tools for Assessing Chemicals under the Toxic Substances Control Act (TSCA)} Providing quantal response models, which are also used in the U.S. EPA benchmark dose software suite, and generates a model-averaged dose response model to generate benchmark dose and benchmark dose lower bound estimates.

The software-based tool “ToxRTool” (Toxicological data Reliability Assessment Tool) provides comprehensive criteria and guidance for evaluations of the inherent quality of toxicological data, thus making the decision process of assigning reliability categories more transparent and harmonised. ToxRTool consists of two parts, one to evaluate in vivo and one to evaluate in vitro data.The primary result of the tool is the assignment of Klimisch categories 1, 2 or 3 (Klimisch et al., 1997). Additionally, the tool offers the option to assign a Klimisch category according to personal judgement.