Mouth & Nasal Uses

The effects of chlorine dioxide (ClO2), sodium hypochlorite (NaOCl), and hydrogen peroxide (H2O2) on cell death and the cell cycle of human gingival f…

Objective This work aims to determine the efficacy of preprocedural oral rinsing with chlorine dioxide solutions to minimize the risk of coronavirus disease 2019 (COVID-19) transmission during high-...

PDF | Chlorine dioxide (ClO2) is a high-level disinfectant that is safe and widely used for sterilization. Due to the limitations on preparing a stable... | Find, read and cite all the research you need on ResearchGate

"TheraBreath toothpastes and oral rinses can help reduce the appearance of canker sores. Further, they contain an exclusive ingredient developed by Dr. Katz called OXYD-8, a stabilized form of chlorine dioxide that eliminates oral bacteria responsible for halitosis, periodontal disease, and dry mouth syndrome. While researchers do not think that anaerobic bacteria are an underlying cause of canker sores, many people suffering from chronic mouth lesions may also have dry mouth and/or bad breath."

We investigated the effectiveness of chlorine dioxide (ClO2) solution in comparison to sodium hypochlorite (NaOCl) and chlorhexidine gluconate (CHX) in the elimination of intracanal Enterococcus faecalis biofilm. Extracted human teeth were inoculated with E. faecalis.

"found out the components within the Xlear nasal sprayTM, particularly grapefruit seed extract (GSE) and xylitol, were successful in statistically significant reduction of the viral load of SARS-CoV-" "5.9. Nasal Delivery of Hypochlorous Acid Hypochlorous acid (HClO), which is known as a potent broad-spectrum antibacterial agent, has shown strong antimicrobial (antibacterial, fungicidal or virucidal) effect in nasal formulations ... a unique Acid-Oxidizing solution (AOS2020) containing pure and stable HClO in a liquid carrier solution, using APR’s Tehclo™ nanotechnology delivery platform, which entraps HCLO in an aqueous solution, enabling its inhalation. AOS2020 comprises a hypotonic solution with unique physicochemical characteristics in terms of pH 2.5–3, oxidative reduction potential 1000–1200 mV and free chlorine species of which pure HClO is not less than 95%... The study involves COVID-19 patients with mild symptoms of the disease and aims at evaluating the efficacy and safety of the spray product in reducing viral load in the upper respiratory airways in recently infected individuals. Results, when available, could represent an additional near-term protective option that could be particularly helpful in high-risk environments."

Ivermectin is an FDA-approved broad-spectrum anti-parasitic agent that has been shown to inhibit SARS-CoV-2 replication in vitro.We aimed to assess the therapeutic efficacy of ivermectin mucoadhesive nanosuspension intranasal spray in treatment of patients ...

****!!!!**** "severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), SARS-CoV, human coronavirus (HCoV) 229E, influenza A (H3N2), rhinovirus type 14, adenovirus type 5, and herpes simplex virus (HSV) type 1 and 2 were examined." "Stabilized chlorine dioxide containing ClōSYS® oral care products reduced the viral load of multiple viruses within 30 s."

****!!!!****

Nothing works faster and lasts longer to stop bad breath than TheraBreath, says independent clinical mouthwash stdy conducted by Essex Testing.

****!!!! "suggesting that one of the main mechanisms of action of chlorine dioxide may be irreversible inhibition of the major cysteine to H2S enzyme, cysteine desulfhydrase."

{Sinusave} non-irritating hygienic composition consisting essentially of a product of compounding under homogenizing conditions water, 0.01% to 5% by weight, as chlorine dioxide, of a source of chlorine dioxide; 0.01% to 3% by weight of at least one olfactory stimulant, 0 to 5% by weight of at least one fixative compound less volatile than the olfactory stimulant 0.1 to 2.5% by weight of at least one inorganic salt selected from the group consisting of alkali metal chloride, alkali metal bicarbonate, and alkali metal chlorate; and 0.0002 to 0.006% (as aluminum) by weight of at least one water soluble aluminum compound, provided that the total concentration of inorganic salt is in the range from 0.6% by weight to 2.5% by weight, holding the composition within the nostril for a hygienic holding period, and discharging the composition from the treated nostril.

****!!!!****!!!!**** {Freshclor mouth rinse brand is associated with CloSYS}

Stabilized chlorine dioxide has been used as an antimicrobial ingredient in mouth rinses for decades, and now, it's helping keep dental professionals safe during the COVID-19 pandemic.

****!!!!**** "Because ClO2 readily degasses from ACD, there needs to be a way to maintain and measure the ACD solution in real time. In our studies, we found that pH and oxidation-reduction potential (ORP) change as a function of chlorine dioxide concentration and are easily controlled and measured." "Through use of this continuous monitoring and automatic dosing system, the water ORP was controlled between 800 and 860 mV. This range is the effective concentration of chlorine dioxide that is without chlorine-like odor and microorganism growth. The ACD dental chair controlled the total bacterial count to 5 CFU/mL and the chlorite concentration was less than 0.0004 mg/L, meeting legal standards of Taiwan, the USA, and China. In addition to the application of ACD in dental chairs, it may also be used in closed water systems for food, cosmetics, beverages, and other industries."

{CloSYS}

{benzalkonium} "its patented nanotechnology, which uses oil-in-water nano-droplets for products applied to the skin and nose. The droplets are small enough to be applied to the skin, the company says, but too large to get into the bloodstream." ""It's approved for use by the FDA as a treatment to kill germs on the skin," Dr. Costley said of the company’s nanotechnology. "As long as we stay within the FDA guidelines, we're approved for uses in the United States.""

Since the spread of SARS-CoV-2 became a pandemic, the number of cases has been continuously growing worldwide. Numerous recommendations and suggestions have been published to prevent the acquisition ...

Egyebek mellett torokfájás, ínygyulladás, herpesz, sebek, illetve gombás megbetegedések kezelésére is használták a magyar fejlesztésű Solumium termékeket. Ám nemrég megtiltották a forgalmazásukat - mondta Noszticzius Zoltán a SOLUMIUM Kft. ügyvezetője.

{Testing of nasal rinses and mouthwashes against COVID-19}

"recently developed hyper-pure and stabile 0.12% ClO2 solution (Solumium)"

****!!!!****!!!!**** "SORE THROAT: To treat... intense gargling 3 times in a series... Pain caused by the illness will decrease substantially in the first 5-15 minutes after treatment, with all symptoms normally disappearing in a few hours." "Blocked Nose... Gingivitis... Fungal Infections... Disinfection of Scratches and Abrasions of the Skin..." "SOLUMIUM ORAL may be effective even after several years of storage" "Must be diluted to a concentration below 0.8 mg/l before released to surface water"

"Chlorhexidine inhibited plaque growth significantly more than the mouthrinse containing chlorine dioxide...The results of the questionnaire showed that the panelists found chlorhexidine easier to use and more effective. However, they preferred the taste of the chlorine dioxide mouthrinse and experienced less taste alterations."

A Utah company, Xlear [xylitol nasal spray], is being sued by the Federal Trade Commission over claims its nasal sprays can stop COVID-19.

{Solumium chlorine dioxide}

This series of papers consisting of three communications describes the properties and applications of chlorine dioxide (ClO2) with a special emphasis on its hyper-pure aqueous solution available commercially in Hungary under the trade name SOLUMIUM DENTAL since the end of 2008. This first part of the series discusses the history of chlorine dioxide as a disinfectant, its properties and its fields of applications. It is also explained why chlorine dioxide is regarded as an ideal biocide and why its medical applications were delayed until now in spite of its advantageous properties as a biocide. The history of chlorine dioxide ClO2 and its fields of application Chlorine dioxide is a greenish yellow gas, easily soluble in water and aqueous solutions. It had been known for long. It was discovered by Sir Humphry Davy in 1811, however it became well known in the XX century only. The largest quantities are used in the paper industry for whitening cellulose. In this application it replaced chlorine because the latter produces dioxin which is carcinogenic. Its second most important field of application is the disinfection of municipal water. For this purpose it was first used in the small town of Niagara Falls next to the Niagara Water Falls in 1944 substituting chlorine. Chlorine dioxide has many favourable properties compared to chlorine. Its disinfectant effect exceeds that of chlorine, moreover it does not chlorinate organic compounds. In Niagara Falls the water was contaminated with phenol, which caused the problems, because chlorine transformed phenol into chlorophenol, which gave the water a really bad taste. What is more, during the chlorination of water so-called trihalo methanes (THM) are formed, which are carcinogenic. It is therefore advisable to change over from the cheaper chlorine to the more expensive but healthier chlorine dioxide where the water contains a higher amount of organic materials. This had been done first in 1956 in Bruxelles among the big cities. Application of ClO2 in the food industry, oral hygiene and dentistry Recently chlorine dioxide solutions were introduced for other purposes, like in the United States for washing fruits and meats. Besides disinfection chlorine dioxide can be used also for deodorizing, for mouthwash, and for other purposes. Chlorine dioxide not only kills all the bacteria responsible for bad breath but directly reacts with the sulphur containing compounds (like sulphurhydrogen, methyl-mercaptan and dimethyl-sulphide) causing the bad breath, and this way successfully stops halitosis as demonstrated by a very thorough Japanese study [1]. The same paper emphasizes two important advantages of mouthwashes made with chlorine dioxide compared to those containing chlorohexidine: the former does not discolour the teeth and tongue and even its continuous use does not produce unwanted side effects. The wide spread of these mouthwashes has been hindered as besides chlorine dioxide they also contained other chemicals which unfavourably affect on one side the quality and on the other side the long term stability of these mouthwashes. To avoid problems caused by the instability chlorine dioxide can be prepared on the spot by mixing the necessary chemicals. This procedure is used e.g. by the DioxiCare [2] system of the Frontier Pharmaceutical firm in New York, which is recommended also for stopping toothache. The local production of chlorine dioxide solves only the problem of durability, however, the chemicals needed for the ClO2 production still stay in the mixture.

"DioxiWhite Pro Teeth Whitening System with DioxiCare 500-750 ppm"

(2020). {***Click "Display Table" button for important dosing instructions***} " tolerability data-on-file (2017) shared by Sinox Pharma, Inc. show that a 0.008% (wt/vol %) ClO2 solution derived from ASC is nonirritating when administered as an intranasal cleanser to individuals with sub-clinical or clinical sinusitis." "more recent evaluations in animals and humans demonstrate that exposure to low concentrations of ASC or ClO2 (≤0.2% and 0.02%, [2000 ppm ASC and 200 ppm ClO2] respectively) such as those found to be effective in human mouth rinse studies are well tolerated" "Snoot™ (Sinox Pharma, Inc.) at the ‘Original’ strength. This formulation yields between 60 parts per million (ppm) and 75 ppm (~0.01% wt/vol) ClO2 over the course of 12 hours" "DioxiRinse™ (Frontier Pharmaceutical, Inc.) to be used at the ‘Standard Strength’ yielding a concentration of ~40 ppm (0.006% wt/vol) ClO2." "immediate cleansing using both products is suggested, even if the recommended maximum use of 4 times in a 12-hour period is exceeded. However, 6 administrations in a 24-hour period are strongly discouraged."

(2008)

(2008)