Mouth & Nasal Uses

"Antibacterial properties of sodium hypochlorite (NaOCl), chlorhexidine gluconate (CHX), Listerine®, and high purity chlorine dioxide (Solumium, ClO2) on selected common oral pathogen microorganisms and on dental biofilm in vitro." "The results have showed that hyper pure ClO2 solution is more effective than other currently used disinfectants in case of aerobic bacteria and Candida yeast. In case of anaerobes its efficiency is similar to CHX solution. The biofilm dissolving effect of hyper pure ClO2 is significantly stronger compared to CHX and Listerine® after 5 min treatment." [Download similar data at https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwje2I-O_ofxAhVBHKYKHVJ0DMcQFjAHegQIERAE&url=https%3A%2F%2Fwww.escmid.org%2Fescmid_publications%2Fonline_lecture_library%2Fmaterial%2F%3Fmid%3D16383&usg=AOvVaw0jFFG1x1optl48d1RAWeT-]

"Why Use CloSYS or ProFresh? The chlorine dioxide ingredient in both products offers 2 benefits. It complements Listerine by more effectively killing the oxygen hating anaerobic bacteria. Focus on bathing your back teeth and tongue. This is where anaerobic bacteria live, and deeper pockets usually form around your back teeth first."

"One mouth rinse growing in use and popularity among cancer patients contains stabilized chlorine dioxide (SCD)and has shown no adverse side effects. This article presents the results of patient interviews conducted to determinethe effectiveness of SCD products in alleviating medically-induced oral mucositis. Included are 5 case histories thatreflect positive, yet diverse, experiences of cancer patients using SCD oral health products during, and after, theircancer treatments"

CloSYS ingredients -stabilized chlorine dioxe naturally activated by the amino acids in saliva.

DioxiCare System developed by Howard Alliger, founder of Frontier & pioneer in the chemistry of chlorine dioxide. first to patent chlorine dioxide for use on the body,1978. Company now led by his daughter Valerie. "If interested in learning more about this research, feel free to contact us. "

{Full paper} {Probably Solonium} "First of all, it is used to disinfect the root canal instead of sodium hypochlorite, but it is also used to treat aphthous, herpes and other oral infections and to reduce inflammation. The positive experiences are reported in a series of articles published in Dental News in 2009. In our opinion, in the near future, hyperpure chlorine dioxide will have many other applications in addition to dentistry as medical, hospital and industrial disinfectants."

**** White Papers and Studies available on Frontier's Active Chlorine Dioxide Mouthwash, Toothpaste, Periodontal Gel, and other DioxiCare® products.

We investigated the effectiveness of chlorine dioxide (ClO2) solution in comparison to sodium hypochlorite (NaOCl) and chlorhexidine gluconate (CHX) in the elimination of intracanal Enterococcus faecalis biofilm. Extracted human teeth were inoculated with E. faecalis. After preparation the canals we …

Background: Aerosols generated during ultrasonic scaling is a potential risk factor for cross-contamination in dental settings. The aim of this study is to evaluate and compare the efficacy of commercially available chlorine dioxide as preprocedural mouthrinses in reducing the level of viable bacteria in aerosols. Materials and Methods : This single-center clinical double-blinded study was conducted over a period of 4 months. A total of 80 patients were divided randomly into two groups (A and B) of 40 patients each to receive the chlorine dioxide mouthwash and water as preprocedural rinse. ...

**TABLE 1. Microbicidal effect of free chlorine on microorganisms. "Immersion in sodium hypochlorite removed 5.6 log units of bacteria found on Dental impressions contaminated by in vivo use and was the most effective disinfectant (versus chlorine dioxide, etc) tested." "CHARACTERISTICS OF THE IDEAL DISINFECTANT--Positives and negatives of bleach"1997

{Solumium} We observed an antibacterial effect of ClO2 and NaOCl gas phases onE. faecalis growth, but not of CHX. ClO2eliminates intracanal biofilm and keeps root canal nearly free from bacteria. "his molecule is unique because it dissolves in aqueous solutions, oil as well as apolar organic solvents. Therefore, ClO2 is not only a surface disinfectant. It has the ability to penetrate into the skin and ucous membranes in a few tenth of millimeters depth" "metastabilized 0.04% and 0.16% chlorous acid/ClO2 (MECA) mouthwash was also found beneficial" "Solumium Dental (1200 ppm ClO2) and Solumium Oral (300 ppm ClO2)" "Mixed-on-site 10% (Clidox-S) or 13.8% (BioClenz) ClO2 solutions... However, the 10% and the 13.8% mentioned in these papers were probably mistakenly written as ClO2 concentration, they are rather the sodium chlorite (precursor) concentrations,"

"Cetylpyridinium chloride is a simple molecule that is cheap, safe, clinically approved, widely accessible in hospitals and the consumer sector and which could enter clinical trials immediately. If reported to have activity in vitro against SARS-CoV-2 subsequent delivery in the form of a mouthwash or nasal spray containing this compound may be an effective way both to combat the virus at its point of entry and reduce SARS-CoV-2 transmission. Similarly, this compound could be added to shampoo and body cleansers so that one could effectively bathe in low concentrations of this compound to destroy shed coronavirus."

White Papers and Studies available on Frontier's Active Chlorine Dioxide Mouthwash, Toothpaste, Periodontal Gel, and other DioxiCare® products.

A low irritation nasal composition for the prevention and treatment of cold and flu viruses comprising pyroglutamic acid and an organic acid having a dissociation constant (pKa) value of 3.0 to 5.0. wherein the composition has a pH of less than 4, 5 and the combination of said pyroglutamic and organic acids provides a superficial pH of the nasal cavity tissue of pH 3, 5 to 5, 5.

***!!!!*** "by exposing affected tissue of the sinus and contiguous tissue in the, nasal cavity and greater oral cavity to effective amounts" "in order to maintain the substantially same concentration... within the range of about 10 ppm to about 20 ppm from the first few seconds up to about a minute or so after the initial formation of chlorine dioxide for up to 2 or 3 days, the composition comprises a carbohydrate, including a sugar such as ribose and a hydroxyl free aldehyde such as cinnamic aldehyde in combination as a disproportionation agent, sodium chlorite and acid to provide a pH... of about 6.0" "The inclusion of a disproportionation agent (preferably a hydroxyl free aldehyde...) in combination with an acid and a salt of chlorite... will speed the production of chlorine dioxide and minimize the residual chlorite for maximum effect." "speeding the release of chlorine dioxide at mild acidity" " glycerin is one of the few emollients that can be used with chlorine dioxide since it will not be oxidized. Glycerin, then, is an acceptable additive to the chlorine dioxide antiseptic solution. It also tastes good." "Numerous acids may be used... including a variety of organic acids, for example, citric, propionic, fumaric, glycolic, lactic, malic, tartaric and acetic" "mucus looseners, such as... and/or guaifenesin to loosen the mucus on the exposed membranes which may be safely ... delivered to the patient, among other optional components" "the composition is administered first by gargling, following by administering the compositions by nasal spray, inhalation and/or nasal lavage." "“neti pot,” usually produces fast results. The concentration of chlorine dioxide may also be lowered to about half that which is used in the nasal spray." " its ability many times to oxidize and neutralize the body's irritating... inflammatory cytokines, enzymes, and oxygen radicals. Eosinophil peroxidase, for example, a white blood cell formation, is probably neutralized by chlorine dioxide oxidation. The importance of this action is obvious in that, aside from the peroxidase killing invading fungus cells, which was nature's purpose, the enzyme is involved in mucus membrane attack and probably the illnesses of 35 million chronic fungal sinusitis patients." [Mouth gargle and nasal rinse at] "about 15 ppm" "each nostril was sprayed while briskly breathing in at the same time. Again, with infection present, there was mild burning for a moment"

To reduce inflammation and improve breathing. The disclosure is also related to a composition for freshening and cleansing the sinus cavities and nostrils that includes a homeopathic ingredient and saline carrier solution. The disclosure is also related to the use of such composition to provide many anticipated and unexpected benefits that emanate from cleansing debris and microbes from the sinuses and nostrils.

Previous research has shown the oxidizing properties and microbiological efficacies of chlorine dioxide (ClO[2] ). Its clinical efficacies on oral malodor have been evaluated and reported only in short duration trials, moreover, no clinical studies have ...

Irrigation plays an indispensable role in removal of tissue remnants and debris from the complicated root canal system. This study compared the human pulp tissue dissolution by different concentrations of chlorine dioxide, calcium hypochlorite and sodium ...

Within the limitations of this study, Chlorax (4.65% NaOCl) dissolved tissue faster than the Ca(OCl)(2) solutions and Tesco thin bleach (1.36% NaOCl) over the first 35 minutes, but there were no significant differences among the solutions thereafter.

The organic tissue dissolution properties of irrigating solutions are important for the success of endodontic treatment. Chlorine dioxide (ClO2) has been recently proposed as an irrigation solution in endodontics. The organic tissue dissolution property of sodium hypochlorite (NaOCl) is well-known a …

Sodium hypochlorite (NaOCl) is recommended as an endodontic irrigant in view of its broad antimicrobial and tissue dissolution capacities. To enhance its penetration into inaccessible areas of root c...

Maria Perno Goldie, RDH, MS, reviews the findings from some studies that have sought to identify the importance of and barriers to effective oral hygiene, as well as implications of poor oral health and the most recommended methods of providing oral care to mechanically ventilated patients.

PDF | Aims and Objectives: Ventilator-associated pneumonia is associated with increased morbidity and mortality. The aim of this pilot study was to... | Find, read and cite all the research you need on ResearchGate

Download Citation | On Dec 20, 2012, Ali Hajibagheri and others published Mouth Care in Patients Receiving Mechanical Ventilation: A Systematic Review | Find, read and cite all the research you need on ResearchGate

Ventilator‐associated pneumonia (VAP) is defined as pneumonia developing in people who have received mechanical ventilation for at least 48 hours. VAP is a potentially serious complication in these patients who are already critically ill. Oral ...

In this analysis, nasal colonization with MRSA was found to be a poor predictor for the subsequent occurrence of MRSA lower respiratory tract infections and MRSA bloodstream infections requiring antimicrobial treatment. Clinicians should be cautious in using the results of nasal-colonization testing …