An in vitro study comparing a two-part activated chlorine dioxide oral rinse to chlorhexidine
"The difference in effectiveness between the chlorine dioxide gas of Oracare and stabilized/precursor forms of chlorine dioxide (sodium chlorite) was evident as none of the mouthrinses using the latter inactivated significantly greater levels of VSCs than the water control." "The MICs for Oracare were higher than those for chlorhexidine when compared directly against a panel of 11 microbial species. However, when normalized to parts per million of the active ingredients, the Oracare rivaled the activity of chlorhexidine and exceeded it in activity toward the periodontal pathogen Aggregatibacter actinomycetemcomitans. The Oracare rinse removed a statistically higher percentage of VSCs than chlorhexidine"