2004 Sept. {Summary from Toxicological Profile}

Nov 1990 thru Oct 2000. {Safety levels for people}

2004 Sept. ********No reports were located in which gastrointestinal, musculoskeletal, endocrine, dermal, or metabolic effects were associated with inhalation exposure of humans or animals to chlorine dioxide or chlorite. *******Example concentrations: 150 ppm (420 mg/m3), 10 ppm (28 mg/m3), etc. {Contact info for Association of Occupational and Environmental Clinics (AOEC) & American College of Occupational and Environmental Medicine (ACOEM)}

***** 1999 {Efficiency of various generating methods, Concentration & time. Etc.} "Higher strength solutions of sodium chlorite (e.g., 37 percent) also are more susceptible to crystallization or stratification at ambient temperatures as high as 25°C (78°F)." "In water treatment, chlorine dioxide solution concentrations rarely exceed 4 g/L for temperatures less than 40°C, and treatment levels generally range from 0.1 to 5.0 mg/L. " "Chlorine dioxide can be easily removed from dilute aqueous solution by turbulent aeration"

{regarding lab test on interaction with berries, as impacting health concerns}

*******!!!!***** {Going into effect 2021 or 2022. EPA core review docket for Chlorine Dioxide application guidelines and health safety}

********2021

*********** Going into effect in 2021****

2003

{Includes statements about chlorine dioxide's effects on human body.}

2007. Chlorine dioxide final volume 5

2006 Aug. "Readers are referred to USEPA (2000a) for a detailed review of the effects seen at specific concentrations and exposure durations along with the derivation of the RfC."

{Safety info for public from ATSDR (Agency for Toxic Substances & Disease Registry) }

**** 2017 Jan. "Any chlorine dioxide remaining at the consumer’s tap will be reduced to chlorite and chloride upon ingestion. *** Consequently, a guideline value for chlorine dioxide has not been established."..."For chlorite, JECFA established an ADIof 0–0.03mg/kg bw on the basis of the NOAEL of 3mg/kg bw per day...Using the upper bound of the chlorite ADI of 30 μg/kg bw, a typical human body weight of 60 kg, the assumption that drinking-water contributes80% of the total exposure and a typical consumption of 2 L of water per day, the provisional guideline value is calculated to be 0.7mg/L (rounded figure). This guideline value is designated as provisional because use of chlorine dioxide as a disinfectantmay result in the chlorite guideline value being exceeded, " "JECFA therefore established an ADIof 0–0.01 mg/kg bw for chlorate" "[Page 1] Conversion factor in air: 1 part per million (ppm) = 2.8 mg/m3"

Aug 2006. "Readers are referred to USEPA (2000a) for a detailed review of the effects seen at specific concentrations and exposure durations along with the derivation of the RfC."

2005.

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General CD info from California Office of Environmental Health Hazard Assessment