How a hidden brain circuit fuels fibromyalgia, migraines, and PTSD | ScienceDaily
What if your brain is the reason some pain feels unbearable? Scientists at the Salk Institute have discovered a hidden brain circuit that gives pain its emotional punch—essentially transforming ordinary discomfort into lasting misery. This breakthrough sheds light on why some people suffer more intensely than others from conditions like fibromyalgia, migraines, and PTSD. By identifying the exact group of neurons that link physical pain to emotional suffering, the researchers may have found a new target for treating chronic pain—without relying on addictive medications.
Novel Lyme Disease Vaccine Effective Across All Ages
The investigational Lyme disease vaccine VLA15 shows favorable safety profile and strong immunogenicity across all age groups, with particularly robust responses in children and adolescents.
2,510 likes, 140 comments - unbiasedscipod on August 14, 2023: "Lyme disease (LD): while a public health concern, rampant misinformation fueled by vocal advocacy organizations has led the public to perceive it as a bigger threat than it is.
One of the most pervasive: chronic Lyme disease.
LD is a bacterial infection caused by Borrelia burgdorferi (rarely Borrelia mayonii in the US; Borrelia garinii & Borreli afzelii in Europe). In the US, 2 species of ticks can transmit these bacteria: Black-legged & western Black-legged ticks. It is not spread by other ticks, other arthropods, or by other means.
Most infections remain localized, cause mild illness, and present with the ‘bulls-eye rash’, erythema migrans. Other symptoms are generic: fever, fatigue, headache, muscle/joint pain, and lymphadenopathy.
In ~10-20% of infections (depending on bacterial strain), bacteria can spread elsewhere in the body like large joints and nerves and cause disseminated LD symptoms, which can be painful and debilitating.
The good news? The bacteria can be killed with antibiotics. Even without antibiotic treatment, most infections would be eliminated by your immune system.
In a small proportion of individuals who TRULY were infected, certain symptoms - fatigue, musculoskeletal pain, insomnia - may last after antibiotic treatment. These are post-treatment Lyme disease syndrome (PTLDS) symptoms, or sequelae, and are a result of the immune response – inflammation created to eliminate bacteria. PTLDS typically resolves over a period of months, like other post-infection sequelae.
This is NOT chronic infection. Bacteria are not hiding, persisting, or establishing dormancy or biofilms. Infection does not reactivate over the years. There is NO benefit to taking longer-term antibiotics. Bacteria are eliminated. Chronic Lyme disease is not a medically supported condition, no matter how loud advocacy organizations shout.
Unfortunately, chronic Lyme has become a scapegoat for an array of non-specific symptoms even without evidence someone had Lyme to begin with. This prevents people from addressing real causes of their symptoms and undergoing harmful and expensive ‘treatments’, as well as propagating fallacies and undue fear about Lyme to the public.".
11K likes, 527 comments - unbiasedscipod on August 9, 2023: "“Chronic Lyme” is a scapegoat in the ‘alternative health’ & ‘wellness’ industries. Many nonspecific symptoms are falsely attributed to a bacterial infection readily treated with antibiotics.
This trend has increased due to celebrity & media attention. We have discussed Lyme pseudoscience extensively, but with recent headlines about Bella Hadid, we must revisit.
Bella shared this 2016 ‘lab report’ filled with Lyme misinformation.
Here are the most glaring.
1️⃣Urine samples cannot be used to diagnose ANY of these, Lyme or otherwise. Credible expert organizations including Infectious Diseases Society of America are explicit about this.
2️⃣FDA-authorized Lyme tests assess immune responses (antibodies) to Borrelia burgdorferi in blood. There are NO credible Lyme tests that use PCR (what this test claims to use).
3️⃣The test falsely claims the first 4 ‘microbes’ listed are different species of Lyme bacteria.
4️⃣This test “detects” SEVERAL impossible co-infections alongside Lyme:
Bartonella bacilliformis only occurs in the Andes Mtns (South America) between 3,000 and 10,000 ft. of elevation. It is transmitted by sand flies, NOT ticks.
Bartonella henselae is also NOT spread by ticks, but by fleas (or animal scratch contaminated with infected flea feces).
Ehrlichia chaffeensis is transmitted by ticks, but NOT the species that transmits Lyme bacteria.
The likelihood Bella was bitten by 4 different arthropods all infected with these bacteria (incl. one only in S. American mountains) is near zero. It is also implausible she has been infected for over 7 years.
Self-appointed “Lyme specialists” have gotten rich by selling fake tests to diagnose illnesses that there is zero evidence (clinical or epidemiological) to support. They then prescribe unproven, harmful, long-term, and expensive treatments.
Is Bella feeling ill? Possibly! But it is very likely the array of “treatments” for infections she doesn’t have are the cause of that.
Unfortunately, celebrities who buy into the myths about Lyme fall prey and legitimize it with their large public platforms. Scientists, credible clinicians, and media outlets all need to help dispel this type of harmful nonsense.".
LIVE Mind-Body Tools to Thrive With Addiction or Chronic Illness
LIVE Mind-Body Tools to Thrive With Addiction or Chronic Illness 🤖 Use https://DocSnipes.com/Clones to get answers to mental health questions and inline ci...
Exercise worsens brain metabolism in ME/CFS by depleting metabolites, disrupting folate metabolism, and altering lipids and energy, contributing to cognitive dysfunction and post-exertional malaise. : r/science
New Technology to Revert Cancer Cells to Normal Cells. Groundbreaking technology can treat colon cancer by converting cancer cells into a state resembling normal colon cells without killing them, thus avoiding side effects. This study was done in mice.
2.8K votes, 32 comments. 34M subscribers in the science community. This community is a place to share and discuss new scientific research. Read about…
That chronic Lyme exists in the realm of experience doesn’t mean it isn’t real. When medicine does not acknowledge the reality of the subjective—the thick reality of lived experience—we fall laughably short in our efforts to serve patients. When it comes to tick-borne Lyme disease itself, we all need to expand our horizons. That suffering is real. It must be attended to. But to insist beyond all plausibility that one’s suffering is related to a tick bite is not feminist; it’s absurd. And to prey on suffering people who crave that certainty, offering them expensive, intensive, and dangerous treatments is worse than absurd; it’s cruel.
Leukemia in traditional Chinese medicine, White blood
The disease is caused by internal heat toxins which damage the essential substance and invade the bone marrow, resulting in consumption of blood and impairment of Yin.
Frontiers | Traditional Chinese medicine for acute myelocytic leukemia therapy: exploiting epigenetic targets
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy with historically high mortality rates. The treatment strategies for AML is still in...
Leukaemia Relief with Traditional Chinese Medicine - Me & Qi
Gain insights into leukaemia through the lens of Traditional Chinese Medicine on Me & Qi. Delve into the causes and explore natural TCM remedies for effective relief and wellness.
Most Cancer Treatments Near End of Life Are Useless: Study - Drugs.com MedNews
Cutting-edge cancer treatments are essentially useless for patients barely clinging to life, a new study shows. Chemotherapies, immunotherapies, targeted therap
The end of inflammation? New approach could treat dozens of diseases.
Cancer, aging, and severe COVID-19 have all been linked to damage from inflammation. Now scientists are flipping their focus to find new drugs that may revolutionize treatments.
Lyme disease: The pathogen's cunning strategies for persistent infection offer clues for vaccine development
Lyme disease is the leading vector-borne disease — meaning diseases that are transmitted to humans from another organism like a tick or mosquito — in North America and Europe. New human cases are estimated at over 400,000 in the United States each year. Canada has experienced a drastic increase in human cases, from 266 cases in 2011 to 3,147 in 2021, as the habitat of its vector, a tick, expands north. The initial symptoms of human Lyme disease...
My research focus is on arthropod vector- host-pathogen interactions. I aim to understand at the molecular level how pathogen infection levels are sustained in
Everything about Lyme disease is steeped in controversy. Now some doctors are too afraid to treat patients
These three Canadians say they are struggling with a chronic form of Lyme disease and feel abandoned by a health-care system divided over how to diagnose and treat the expanding illness.
Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion
Gutierrez Ruiz et al. analyzed the lysosomal proteome of pancreatic cancer cells expressing
oncogenic KRAS. They identified the GEF DOCK8 as being aberrantly expressed in pancreatic
cancer cells, where it controls lysosome morphology. DOCK8 regulates lysosomal actin,
which impacts trafficking and secretion of lysosomal cathepsins to promote tumor cell
invasion.
Researchers make unexpected discovery in how pancreatic cancer spreads
How cancer spreads or metastasizes is a big question for cancer researchers and patients. Mayo Clinic researchers studying pancreatic cancer—the third deadliest form of cancer in the U.S.—recently made a discovery that advances knowledge of how metastasis unfolds. They identified a cell-signaling protein that drives pancreatic cancer cell growth that could be a potential therapeutic target.
Cancer
