Placebo Controlled Trials for Vaccines
Testing & Placebo Controls
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The New Placebo Mandate for Vaccines: Unethical, Unscientific, and Impossible
Earlier this month, HHS Secretary Robert F. Kennedy Jr. announced plans to require all new vaccines to undergo placebo-controlled trials before approval. According to The Washington Post, an HHSâŚ
Randomized Controlled Trials: The Backbone of Vaccine Safety
No, They Don't Skip the Placebo Controls - Here's The Proof.
All Childhood Vaccines Were Tested Against Placebos - Here's the Evidence
Most Used Inert (Saline) Controls. When They Didn't, Science and Ethics Tell Us Why
The facts about placebo controlled vaccine clinical trials
Placebo-controlled studies for a vaccines is flawed. Placebo studies are sometimes unethical, especially when effective alternatives exist.
âNocebo effectâ: two-thirds of Covid jab reactions not caused by vaccine, study suggests
US researchers show negative version of placebo effect behind many symptoms such as headaches and fatigue
RFK Jr. resurrects an old antivax half-truth about âsaline placebosâ in randomized controlled trials of vaccines | Science-Based Medicine
RFK Jr. has resurrected the misleading claim that childhood vaccines have never been tested in randomized controlled trials with a saline placebo controls.
Almost none of the vaccines on the list that werenât licensed based on RCTs using saline controls are not first generation vaccines, which means that it would have been unethical to test them against a saline control.
The bottom line is that, if you trace back the history of the vaccines developed for a disease like, say, measles, you will eventually find the RCT testing the first effective vaccine against it and that vaccine will have had a placebo control. It might not have been saline (although in most cases decades ago it was), but it will have been a placebo that was âinertâ with respect to preventing that disease. Also, clinical trial standards have evolved over the last 70 years. If a vaccine was approved 60+ years ago using methodology that today we might consider inadequate, that does not change the calculus when it comes to testing new vaccines against the same disease. Such vaccines canât ethically be tested against saline placebo.
PolitiFact | Yes, there have been placebo-controlled studies on childhood vaccines
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Where are the Double Blind Placebo Controlled Randomized Trials about Vaccines - VAXOPEDIA
Learn about the role of double-blind, placebo-controlled randomized trials in vaccine research. Explore how they provide reliable evidence on vaccine safety and efficacy.