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Analysis: A landslide majority of American adults have been vaccinated. Here's how that stacks up against other commonplace activities.
Analysis: A landslide majority of American adults have been vaccinated. Here's how that stacks up against other commonplace activities.
The US has now vaccinated 70% of adults with at least one shot against Covid-19, according to the latest data from the US Centers for Disease Control and Prevention, belatedly reaching a milestone the Biden administration had hoped to hit by July 4.
Analysis: A landslide majority of American adults have been vaccinated. Here's how that stacks up against other commonplace activities.
For Seniors Especially, Covid Can Be Stealthy
For Seniors Especially, Covid Can Be Stealthy
With infections increasing once more, and hospitalization rising among older adults, health experts offer a timely warning: a coronavirus infection can look different in older patients.
For Seniors Especially, Covid Can Be Stealthy
See How Vaccines Can Make the Difference in Delta Variant’s Impact
See How Vaccines Can Make the Difference in Delta Variant’s Impact
In a Times simulation, we modeled Delta-driven Covid outbreaks in two communities, one with a high vaccination rate and another with a low rate. Their levels of serious illness and death were starkly different.
See How Vaccines Can Make the Difference in Delta Variant’s Impact
Testosterone's Role in COVID-19
Testosterone's Role in COVID-19
COVID-19 consistently displays a higher mortality in males. This sex-specific difference in outcomes is seen not only in the current COVID-19 pandemic, but also in prior viral epidemics and pandemics. Sex hormones, such as testosterone, play a clear role ...
Testosterone's Role in COVID-19
Effect of the covid-19 pandemic in 2020 on life expectancy across populations in the USA and other high income countries: simulations of provisional mortality data
Effect of the covid-19 pandemic in 2020 on life expectancy across populations in the USA and other high income countries: simulations of provisional mortality data
Objective To estimate changes in life expectancy in 2010-18 and during the covid-19 pandemic in 2020 across population groups in the United States and to compare outcomes with peer nations. Design Simulations of provisional mortality data. Setting US and 16 other high income countries in 2010-18 and 2020, by sex, including an analysis of US outcomes by race and ethnicity. Population Data for the US and for 16 other high income countries from the National Center for Health Statistics and the Human Mortality Database, respectively. Main outcome measures Life expectancy at birth, and at ages 25 and 65, by sex, and, in the US only, by race and ethnicity. Analysis excluded 2019 because life table data were not available for many peer countries. Life expectancy in 2020 was estimated by simulating life tables from estimated age specific mortality rates in 2020 and allowing for 10% random error. Estimates for 2020 are reported as medians with fifth and 95th centiles. Results Between 2010 and 2018, the gap in life expectancy between the US and the peer country average increased from 1.88 years (78.66 v 80.54 years, respectively) to 3.05 years (78.74 v 81.78 years). Between 2018 and 2020, life expectancy in the US decreased by 1.87 years (to 76.87 years), 8.5 times the average decrease in peer countries (0.22 years), widening the gap to 4.69 years. Life expectancy in the US decreased disproportionately among racial and ethnic minority groups between 2018 and 2020, declining by 3.88, 3.25, and 1.36 years in Hispanic, non-Hispanic Black, and non-Hispanic White populations, respectively. In Hispanic and non-Hispanic Black populations, reductions in life expectancy were 18 and 15 times the average in peer countries, respectively. Progress since 2010 in reducing the gap in life expectancy in the US between Black and White people was erased in 2018-20; life expectancy in Black men reached its lowest level since 1998 (67.73 years), and the longstanding Hispanic life expectancy advantage almost disappeared. Conclusions The US had a much larger decrease in life expectancy between 2018 and 2020 than other high income nations, with pronounced losses among the Hispanic and non-Hispanic Black populations. A longstanding and widening US health disadvantage, high death rates in 2020, and continued inequitable effects on racial and ethnic minority groups are likely the products of longstanding policy choices and systemic racism. Data sharing: Requests for additional data and analytic scripts used in this study should be emailed to RKM (Ryan.Masters@colorado.edu).
Effect of the covid-19 pandemic in 2020 on life expectancy across populations in the USA and other high income countries: simulations of provisional mortality data
The Economic Risks from Anti-Vaxxers - The Big Picture
The Economic Risks from Anti-Vaxxers - The Big Picture
To hear an audio spoken word version of this post, click here.   One of the favorite parts of my job is thinking about issues in ways other people often do not. That might include identifying where consensus may be wrong (Inflation, Urban Exodus, Insurrections) or market values responding differently than expected. Even for issues…Read More
The Economic Risks from Anti-Vaxxers - The Big Picture
Drug overdose deaths soared to a record 93,000 last year
Drug overdose deaths soared to a record 93,000 last year
The coronavirus pandemic and the continued spread of illegal fentanyl took a devastating toll on drug users, experts said, as the government reported a staggering increase in fatalities.
Drug overdose deaths soared to a record 93,000 last year
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization | Nature
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization | Nature
The SARS-CoV-2 B.1.617 lineage was identified in October 2020 in India1–5. It has since then become dominant in some indian regions and UK and further spread to many countries6. The lineage includes three main subtypes (B1.617.1, B.1.617.2 and B.1.617.3), harbouring diverse Spike mutations in the N-terminal domain (NTD) and the receptor binding domain (RBD) which may increase their immune evasion potential. B.1.617.2, also termed variant Delta, is believed to spread faster than other variants. Here, we isolated an infectious Delta strain from a traveller returning from India. We examined its sensitivity to monoclonal antibodies (mAbs) and to antibodies present in sera from COVID-19 convalescent individuals or vaccine recipients, in comparison to other viral strains. Variant Delta was resistant to neutralization by some anti-NTD and anti-RBD mAbs including Bamlanivimab, which were impaired in binding to the Spike. Sera from convalescent patients collected up to 12 months post symptoms were 4 fold less potent against variant Delta, relative to variant Alpha (B.1.1.7). Sera from individuals having received one dose of Pfizer or AstraZeneca vaccines barely inhibited variant Delta. Administration of two doses generated a neutralizing response in 95% of individuals, with titers 3 to 5 fold lower against Delta than Alpha. Thus, variant Delta spread is associated with an escape to antibodies targeting non-RBD and RBD Spike epitopes.
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization | Nature