mast cell/mcas

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Diagnosis of mast cell activation syndrome: a global “consensus-2”
Diagnosis of mast cell activation syndrome: a global “consensus-2”
The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of “mast cell activation syndrome” (MCAS) grown significantly. Two principal proposals for diagnostic criteria have emerged. One, originally published in 2012, is labeled by its authors as a “consensus” (re-termed here as “consensus-1”). Another sizable contingent of investigators and practitioners favor a different approach (originally published in 2011, newly termed here as “consensus-2”), resembling “consensus-1” in some respects but differing in others, leading to substantial differences between these proposals in the numbers of patients qualifying for diagnosis (and thus treatment). Overdiagnosis by “consensus-2” criteria has potential to be problematic, but underdiagnosis by “consensus-1” criteria seems the far larger problem given (1) increasing appreciation that MCAS is prevalent (up to 17% of the general population), and (2) most MCAS patients, regardless of illness duration prior to diagnosis, can eventually identify treatment yielding sustained improvement. We analyze these proposals (and others) and suggest that, until careful research provides more definitive answers, diagnosis by either proposal is valid, reasonable, and helpful.
·degruyterbrill.com·
Diagnosis of mast cell activation syndrome: a global “consensus-2”
Ivabradine in Cardiovascular Disease Management Revisited: a Review - PubMed
Ivabradine in Cardiovascular Disease Management Revisited: a Review - PubMed
Ivabradine is a unique agent that is distinct from beta-blockers and calcium channel blockers as it reduces heart rate without affecting myocardial contractility or vascular tone. Ivabradine is a use-dependent inhibitor targeting the sinoatrial node. It is approved for use in the United States as an …
·pubmed.ncbi.nlm.nih.gov·
Ivabradine in Cardiovascular Disease Management Revisited: a Review - PubMed
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade - PubMed
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade - PubMed
The activation and degranulation of mast cells (MCs), triggered by a variety of viruses, are intricately linked to viral pathogenesis. However, the precise mechanism underlying virus-induced MC degranulation remains largely unknown. In this study, we demonstrate the ubiquity of coronavirus-induced M …
·pubmed.ncbi.nlm.nih.gov·
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade - PubMed
Low Histamine Probiotics for MCAS
Low Histamine Probiotics for MCAS
The right low histamine probiotics and histamine lowering probiotics can support Histamine Intolerance and MCAS! But which are best?
·mastcell360.com·
Low Histamine Probiotics for MCAS
Kusuri-no-Shiori(Drug Information Sheet)
Kusuri-no-Shiori(Drug Information Sheet)
You can search for reliable information created by pharmaceutical companies. Some of the information is also translated into English. A "drug booklet" is information that describes the medications prescribed by doctors (prescription drugs) in a way that is easy for patients to understand.
·rad-ar.or.jp·
Kusuri-no-Shiori(Drug Information Sheet)
(PDF) Influence of Selenium on Mast Cell Mediator Release
(PDF) Influence of Selenium on Mast Cell Mediator Release
PDF | Selenium supplementation still enhanced the immune response even in individuals who, according to current standards, would be considered as not... | Find, read and cite all the research you need on ResearchGate
·researchgate.net·
(PDF) Influence of Selenium on Mast Cell Mediator Release
Best Probiotics for Mast Cell Activation (MCAS)
Best Probiotics for Mast Cell Activation (MCAS)
We unveil the best probiotics for mast cell activation (MCAS). Learn which probiotic supplements are ideal for people with mast cell activation or MCAS.
Probiota Bifido by Seeking Health
·endsickness.org·
Best Probiotics for Mast Cell Activation (MCAS)
Cimetidine Dosage Guide + Max Dose, Adjustments - Drugs.com
Cimetidine Dosage Guide + Max Dose, Adjustments - Drugs.com
Detailed Cimetidine dosage information for adults and children. Includes dosages for Gastroesophageal Reflux Disease, Dyspepsia, Gastric Ulcer and more; plus renal, liver and dialysis adjustments.
·drugs.com·
Cimetidine Dosage Guide + Max Dose, Adjustments - Drugs.com
New aspects of liver abnormalities as part of the systemic mast cell activation syndrome - PubMed
New aspects of liver abnormalities as part of the systemic mast cell activation syndrome - PubMed
Hypercholesterolaemia and liver abnormalities are frequently found in patients with the mast cell activation syndrome. Hence, the mast cell activation syndrome should be considered at an early stage as a possible cause of hypercholesterolaemia and of hepatic abnormalities of unknown reason. Mast cel …
·pubmed.ncbi.nlm.nih.gov·
New aspects of liver abnormalities as part of the systemic mast cell activation syndrome - PubMed
Mast Cell Activation Syndrome Questions Answered
Mast Cell Activation Syndrome Questions Answered
Do mast cells make you gain weight and have a huge stomach when you are eating almost nothing? I have seen MCAS drive weight gain in some patients, weight loss in other patients…
·drtaniadempsey.com·
Mast Cell Activation Syndrome Questions Answered
Potential role of the common food additive manufactured citric acid in eliciting significant inflammatory reactions contributing to serious disease states: A series of four case reports
Potential role of the common food additive manufactured citric acid in eliciting significant inflammatory reactions contributing to serious disease states: A series of four case reports
Citric acid as a food additive is not natural citric acid; it is manufactured through fermentation using Aspergillus niger. Aspergillus niger is a potent allergen. Food additive manufactured citric acid may be causing allergic inflammatory cascades. ...
·pmc.ncbi.nlm.nih.gov·
Potential role of the common food additive manufactured citric acid in eliciting significant inflammatory reactions contributing to serious disease states: A series of four case reports
The BEST Low Histamine Meat Sources for those with Histamine Intolerance or Mast Cell Disease
The BEST Low Histamine Meat Sources for those with Histamine Intolerance or Mast Cell Disease
Did you know that most meat purchased from the grocery store is very high in histamine levels? This is why many people that have mast cell activation syndrome (MCAS) or histamine intolerance don’t tolerate store-bought meats well.Even though store-bought meats are “fresh”, it has still likely been many days since they were slaughtered. Beef is almost always aged for 15-45 days (when you buy it from the store or a local farm). The longer meats are aged, the higher in histamines they become. Even
·ribeyerach.com·
The BEST Low Histamine Meat Sources for those with Histamine Intolerance or Mast Cell Disease
MCAS/Mastocytosis Treatment
MCAS/Mastocytosis Treatment
Information about treatment options for mast cell activation syndrome and mastocytosis
·mastcellpsa.com·
MCAS/Mastocytosis Treatment
The 1,4-benzodiazepine Ro5-4864 (4-chlorodiazepam) suppresses multiple pro-inflammatory mast cell effector functions
The 1,4-benzodiazepine Ro5-4864 (4-chlorodiazepam) suppresses multiple pro-inflammatory mast cell effector functions
Activation of mast cells (MCs) can be achieved by the high-affinity receptor for IgE (FcεRI) as well as by additional receptors such as the lipopolysaccharide (LPS) receptor and the receptor tyrosine kinase Kit (stem cell factor [SCF] receptor). ...
·pmc.ncbi.nlm.nih.gov·
The 1,4-benzodiazepine Ro5-4864 (4-chlorodiazepam) suppresses multiple pro-inflammatory mast cell effector functions
Turbinate reduction
Turbinate reduction
Radiofrequency turbinate reduction is a procedure in which a needle-like instrument is inserted into the turbinate. Learn more here.
·stanfordhealthcare.org·
Turbinate reduction
Mechanistic understanding of oral drug absorption enhancement of cromolyn sodium by an amino acid derivative - PubMed
Mechanistic understanding of oral drug absorption enhancement of cromolyn sodium by an amino acid derivative - PubMed
The increase in membrane fluidity by SNAC plays a pivotal role in the permeation enhancement mechanism of cromolyn sodium. Therefore, the increase in permeation is a result of changing Caco-2 cell membrane fluidity resulting in change in membrane integrity and not due to an increase in the lipophili …
·pubmed.ncbi.nlm.nih.gov·
Mechanistic understanding of oral drug absorption enhancement of cromolyn sodium by an amino acid derivative - PubMed
Have inadequate delivery systems hampered the clinical success of inhaled disodium cromoglycate? Time for reconsideration - PubMed
Have inadequate delivery systems hampered the clinical success of inhaled disodium cromoglycate? Time for reconsideration - PubMed
Pharmacological efficacy of DSCG has been demonstrated in animals and humans. If the drug is delivered to the site of inflammation in an effective dose, a reliable therapeutic effect can be expected. DSCG has extra properties and potential unspecific antiviral properties and may offer new therapeuti …
·pubmed.ncbi.nlm.nih.gov·
Have inadequate delivery systems hampered the clinical success of inhaled disodium cromoglycate? Time for reconsideration - PubMed
Drug Shortages | FDA
Drug Shortages | FDA
The FDA is responsible for protecting the public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, and medical devices; and by ensuring the safety of our nation's food supply, cosmetics, and products that products that emit radiation.
·dps.fda.gov·
Drug Shortages | FDA