You’re histamine intolerant. Which beers can you drink?
It’s the amber nectar, the answer to the question you can’t remember, and, to quote Homer Simpson, “the cause of and solution to all of life’s problems”. Beer is a beverage enjoyed by millions, but delicious though it may be to many, it can wreak bodily havoc in people with histamine intolerance. Indeed, those who suffer often have very poor tolerance to beer, yet some consume it nonetheless. Here we take a closer look at what beer-drinkers with histamine intolerance need to consider.
Diagnosis of mast cell activation syndrome: a global “consensus-2”
The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of “mast cell activation syndrome” (MCAS) grown significantly. Two principal proposals for diagnostic criteria have emerged. One, originally published in 2012, is labeled by its authors as a “consensus” (re-termed here as “consensus-1”). Another sizable contingent of investigators and practitioners favor a different approach (originally published in 2011, newly termed here as “consensus-2”), resembling “consensus-1” in some respects but differing in others, leading to substantial differences between these proposals in the numbers of patients qualifying for diagnosis (and thus treatment). Overdiagnosis by “consensus-2” criteria has potential to be problematic, but underdiagnosis by “consensus-1” criteria seems the far larger problem given (1) increasing appreciation that MCAS is prevalent (up to 17% of the general population), and (2) most MCAS patients, regardless of illness duration prior to diagnosis, can eventually identify treatment yielding sustained improvement. We analyze these proposals (and others) and suggest that, until careful research provides more definitive answers, diagnosis by either proposal is valid, reasonable, and helpful.
Ivabradine in Cardiovascular Disease Management Revisited: a Review - PubMed
Ivabradine is a unique agent that is distinct from beta-blockers and calcium channel blockers as it reduces heart rate without affecting myocardial contractility or vascular tone. Ivabradine is a use-dependent inhibitor targeting the sinoatrial node. It is approved for use in the United States as an …
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade - PubMed
The activation and degranulation of mast cells (MCs), triggered by a variety of viruses, are intricately linked to viral pathogenesis. However, the precise mechanism underlying virus-induced MC degranulation remains largely unknown. In this study, we demonstrate the ubiquity of coronavirus-induced M …
Gastrointestinal Permeation Enhancers Beyond Sodium Caprate and SNAC ‐ What is Coming Next?
This review focuses on the main challenge of oral peptide delivery - overcoming the epithelial barrier. With many peptide drugs in development, there is a huge unmet need for more efficient intestina...
Revealing the interaction between peptide drugs and permeation enhancers in the presence of intestinal bile salts - Nanoscale (RSC Publishing) DOI:10.1039/D3NR05571J
Meal-Time Supplementation with Betaine HCl for Functional Hypochlorhydria: What is the Evidence?
It is well established that the inadequate intake of key nutrients can lead to nutrient deficiency-related phenomena. However, even when the intake of nutrients is sufficient, the inadequate digestion and/or absorption of macronutrients, ...
You can search for reliable information created by pharmaceutical companies. Some of the information is also translated into English. A "drug booklet" is information that describes the medications prescribed by doctors (prescription drugs) in a way that is easy for patients to understand.
(PDF) Influence of Selenium on Mast Cell Mediator Release
PDF | Selenium supplementation still enhanced the immune response even in individuals who, according to current standards, would be considered as not... | Find, read and cite all the research you need on ResearchGate
We unveil the best probiotics for mast cell activation (MCAS). Learn which probiotic supplements are ideal for people with mast cell activation or MCAS.
Cimetidine Dosage Guide + Max Dose, Adjustments - Drugs.com
Detailed Cimetidine dosage information for adults and children. Includes dosages for Gastroesophageal Reflux Disease, Dyspepsia, Gastric Ulcer and more; plus renal, liver and dialysis adjustments.
New aspects of liver abnormalities as part of the systemic mast cell activation syndrome - PubMed
Hypercholesterolaemia and liver abnormalities are frequently found in patients with the mast cell activation syndrome. Hence, the mast cell activation syndrome should be considered at an early stage as a possible cause of hypercholesterolaemia and of hepatic abnormalities of unknown reason. Mast cel …
Do mast cells make you gain weight and have a huge stomach when you are eating almost nothing? I have seen MCAS drive weight gain in some patients, weight loss in other patients…
Potential role of the common food additive manufactured citric acid in eliciting significant inflammatory reactions contributing to serious disease states: A series of four case reports
Citric acid as a food additive is not natural citric acid; it is manufactured through fermentation using Aspergillus niger. Aspergillus niger is a potent allergen. Food additive manufactured citric acid may be causing allergic inflammatory cascades. ...
The BEST Low Histamine Meat Sources for those with Histamine Intolerance or Mast Cell Disease
Did you know that most meat purchased from the grocery store is very high in histamine levels? This is why many people that have mast cell activation syndrome (MCAS) or histamine intolerance don’t tolerate store-bought meats well.Even though store-bought meats are “fresh”, it has still likely been many days since they were slaughtered. Beef is almost always aged for 15-45 days (when you buy it from the store or a local farm). The longer meats are aged, the higher in histamines they become. Even
Activation of mast cells (MCs) can be achieved by the high-affinity receptor for IgE (FcεRI) as well as by additional receptors such as the lipopolysaccharide (LPS) receptor and the receptor tyrosine kinase Kit (stem cell factor [SCF] receptor). ...
Mechanistic understanding of oral drug absorption enhancement of cromolyn sodium by an amino acid derivative - PubMed
The increase in membrane fluidity by SNAC plays a pivotal role in the permeation enhancement mechanism of cromolyn sodium. Therefore, the increase in permeation is a result of changing Caco-2 cell membrane fluidity resulting in change in membrane integrity and not due to an increase in the lipophili …
Have inadequate delivery systems hampered the clinical success of inhaled disodium cromoglycate? Time for reconsideration - PubMed
Pharmacological efficacy of DSCG has been demonstrated in animals and humans. If the drug is delivered to the site of inflammation in an effective dose, a reliable therapeutic effect can be expected. DSCG has extra properties and potential unspecific antiviral properties and may offer new therapeuti …