Mechanistic understanding of oral drug absorption enhancement of cromolyn sodium by an amino acid derivative - PubMed
The increase in membrane fluidity by SNAC plays a pivotal role in the permeation enhancement mechanism of cromolyn sodium. Therefore, the increase in permeation is a result of changing Caco-2 cell membrane fluidity resulting in change in membrane integrity and not due to an increase in the lipophili …
Have inadequate delivery systems hampered the clinical success of inhaled disodium cromoglycate? Time for reconsideration - PubMed
Pharmacological efficacy of DSCG has been demonstrated in animals and humans. If the drug is delivered to the site of inflammation in an effective dose, a reliable therapeutic effect can be expected. DSCG has extra properties and potential unspecific antiviral properties and may offer new therapeuti …
Fine particulate matter (PM2.5) enhances FcεRI-mediated signaling and mast cell function
Persistent exposure to ambient fine particulate matter (PM2.5) can exacerbate allergic diseases in humans. Mast cells play an important role in allerg…
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Allergen immunotherapy (AIT), including SCIT and SLIT, is a treatment that involves the administration of allergens to which patients with allergic di…
(PDF) Mast cell stabilizing potential of Camel milk (Camelus dromedaries) in the management of asthma
PDF | Objective: To investigate mast cell stabilizing potential of camel milk (Camelus dromedaries) in the management of asthma using experimental... | Find, read and cite all the research you need on ResearchGate
Inhibitory effects of benzodiazepines on the adenosine A2B receptor mediated secretion of interleukin-8 in human mast cells
The activation of adenosine A2B receptors in human mast cells causes pro-inflammatory responses such as the secretion of interleukin-8. There is evide…
Antinuclear antibodies in autoimmune and allergic diseases
Antinuclear antibodies (ANA) are primarily significant in the diagnosis of systemic connective tissue diseases. The relationship between their occurrence in allergic diseases is poorly documented. However, the mechanism of allergic and autoimmune diseases ...
Our observations suggest most positive antibody tests in MCAS patients represent detection of clinically insignificant mimicking antibodies. As such, to reduce incorrect diagnoses of AADs and inappropriate treatment in MCAS patients, caution is warranted in interpreting positive antibody tests in th …
Author’s note: I am not a medical doctor. Anaphylaxis and use of epinephrine must be discussed with the managing provider to determine the best treatment plan for any individual patient. Determination of mast cell reaction vs anaphylaxis Anaphylaxis has a very complicated relationship with mast cell disease. Mast cell symptoms and reactions are inherent… Read More »Anaphylaxis and mast cell reactions