Medical research

ABSTRACT: Lower extremity soft tissues injuries account for a large proportion of musculoskeletal injuries. In cases where medication, physical therapy and cortisone injections do not provide complete relief, dextrose prolotherapy is a viable treatment option that has been available for many decades. In our clinic, dextrose prolotherapy is particularly effective in patients who are hypermobile

Background Ehlers–Danlos syndromes are hereditary disorders of connective tissue that are characterized by joint hypermobility, skin hyperextensibility and tissue fragility. The most common subtype ...

Alternative medicine gurus are analyzing patients' genetic data and divining health information to sell nutritional supplements. Is this modern-day snake oil?

Linked Editorial: Steele and O’Toole. Br J Dermatol 2020; 182:521–522. Linked Comment: Hausser. Br J Dermatol 2020; 182:535–536. Respond to this article

How to download academic papers and books for free pic.twitter.com/slxtHkbFRs— Alex Strasser (@AStrasser116) October 2, 2022

The need of this study is to assess the role of collagen III in all hernias which include primary inguinal hernias ventral and recurrent abdominal hernias.Collagen type III represents the mechanically instable, less cross-linked collagen synthesized during ...

The serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act on serotonin receptors in the intestine and promote intestinal peristalsis, increase gastric emptying and decrease esophageal reflux. Two 5-HT4 receptor agonists have been developed and were approved for use in the United States, but both were found to have significant serious adverse effects and have been withdrawn (cisapride) or placed under restricted use (tegaserod). Both cisapride and tegaserod have been associated with a low rate of transient serum enzyme elevations during therapy, but neither has been implicated convincing in cases of clinically apparent liver injury with jaundice.

Trintellix (vortioxetine) is a brand-name prescription drug that’s used to treat depression. Learn about side effects, dosage, uses, and more.

Coffee is one of the most popular beverages consumed worldwide. Roasted coffee is a complex mixture of thousands of bioactive compounds, and some of them have numerous potential health-promoting properties that have been extensively studied in the cardiovascular and central nervous systems, with rel …

There is a much greater prevalence of obstetric and gynecologic issues reported by women with Ehlers-Danlos syndrome than in the general population. Additionally, rates differed significantly among the three most common types of Ehlers-Danlos syndrome with vascular type having the highest rates of a …

A summary of clinical studies from 2021 and 2022 show that NMN treatment impacts exercise capacity, sleep, and fatigue, and provide insight into safety and dosing strategies.

To characterize the natural history and clinical features of myopathies caused by mono‐allelic, dominantly acting pathogenic variants in COL12A1. Patients with dominant COL12A1‐related myopathies were characterized by history and clinical ...

The study aimed to determine the impact of 6-month rigid brace on back muscle strength and endurance in adolescents with idiopathic scoliosis. Sixty-one girls, aged 7.0-16.0, were analyzed in two groups: the study group (6-month rigid brace wear) vs. the control group (no brace treatment), recruited …

In this month’s “Hot Topic,” Brad Karon, M.D., Ph.D., will discuss recent information on the advantages and disadvantages of using butterfly needles for blood collection.

Previously reported levels of iron absorption from common Southeast Asian meals composed of rice, vegetables, and spices were too low to be consistent with the known prevalence of iron deficiency. In the present paper the cause of the low absorption was systematically sought. Variables investigated …

The amygdala is a highly interconnected region of the brain that is critically important to emotional processing and affective networks. Previous studies have shown that the response of the amygdala to emotionally arousing stimuli can be modulated by sex hormones. Because oral contraceptive pills dr …

Exogenous cortisol administration has been used to test the influence of glucocorticoids on a variety of outcomes, including memory and affect. Careful control of factors known to influence cortisol and other endogenous hormone levels is central to the success of this research. While the use of horm …

A scientist went looking for genes that cause cannabinoid hyperemesis syndrome. But a public spat with a cannabis influencer who suffers from the disease may have derailed his research.

Brushing a patient’s teeth is basic care that often gets skipped when hospitals are busy. Experts warn the danger of unbrushed teeth is greater than realized.

Ehlers-Danlos syndrome (EDS) constitutes a group of connective tissue diseases with variable organ dysfunction. We aimed to examine the comorbidity burden in patients with EDS.A nationwide populati...

Emerging data suggest that risk factors for obesity and insulin resistance such as diabetes during pregnancy and intrauterine growth failure may also have a role in the development of ADHD. Furthermore, ADHD and obesity share lifestyle factors, such as abnormal eating patterns, binge eating, and a s …

Rush and cluster immunotherapy schedules are accelerated immunotherapy build-up schedules. A cluster immunotherapy schedule involves the patient receiving several allergen injections (generally 2-4) sequentially in a single day of treatment on nonconsecutive days. The maintenance dose is generally r …

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Do you struggle to understand the complex interplay of hormones and hypermobility? Yep... me too. Meet Cortney Gensemer, Ph.D., a postdoctoral scholar in the Norris Lab at MUSC. She and her colleagues are at the forefront of Ehlers-Danlos Syndromes (EDS) research. Cortney is a fellow Zebra who understands from first-hand experience how troubling an EDS diagnosis can be. Her disease pushes her to work hard because she aspires to find an answer for all of us. How does she manage it all? Cortney s

Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name “Houpo”, has been traditionally used in Chinese and ...

Upper reference values for testosterone in women must be established from a well-characterized population.

Bacterial lysates, prepared from the microorganisms most frequently involved in human Respiratory Tract Infections (RTIs) have been in the market for several decades, and at present, several different brands are available in many countries worldwide. They all claimed to exert local and systemic immunomodulatory effects but different clinical trials show disparate results between them. The lack of consistency of predicted therapeutic effects has undermined their clinical use and hampered licensing in several countries. One explanation for such lack of consistency in the results is that their methods of preparation are also very different. Here, we review the available literature describing methods of preparation of bacterial lysates, including patent disclosure documents. We found a great variety of methodologies of preparation and a lack of standardized procedures among them. The main conclusion of our study is that there is a clear need for standardized protocols of production to obtain comparable results in clinical trials worldwide.

Probiotics overview for health professionals. Research food and supplement sources, health effects, safety, selection, and use here.