Medical research

Last week, FDA once again changed course in its approach towards regulating pharmacogenomic (PGx) tests.  We have blogged on this story several times before (see past blog posts here and here).  A …

Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addressing the remaining 8% of the genome, the Telomere-to-Telomere (T2T) ...

Nature Aging - The authors compared muscle metabolomes of young and older adults with different muscle health and physical activity levels. They found that aging was characterized by lower levels...

Gray hair is a visible sign of tissue degeneration during aging. Graying is attributed to dysfunction of melanocyte stem cells (McSCs) that results in depletion of their melanin-producing progeny. Th...

Estrogen has a dramatic effect on musculoskeletal function. Beyond the known relationship between estrogen and bone, it directly affects the structure and function of other musculoskeletal tissues such as muscle, tendon, and ligament. In these other musculoskeletal ...

This article reviews microneurographic research on sympathetic neural control in women under both physiological and pathophysiological conditions across the lifespan. Specifically, the effects of sex, age, race, the menstrual cycle, oral contraceptives, ...

Epigenetic “clocks” based on DNA methylation (DNAme) are the most robust and widely employed aging biomarker. They have been built for numerous species and reflect gold-standard interventions that extend lifespan. However, conventional methods for measuring epigenetic clocks are expensive and low-throughput. Here, we describe Tagmentation-based Indexing for Methylation Sequencing (TIME-Seq) for ultra-cheap and scalable targeted methylation sequencing of epigenetic clocks and other DNAme biomarkers. Using TIME-Seq, we built and validated inexpensive epigenetic clocks based on genomic and ribosomal DNAme in hundreds of mice and human samples. We also discover it is possible to accurately predict age from extremely low-cost shallow sequencing (e.g., 10,000 reads) of TIME-Seq libraries using scAge , a probabilistic age-prediction algorithm originally applied to single cells. Together, these methods reduce the cost of DNAme biomarker analysis by more than two orders of magnitude, thereby expanding and democratizing their use in aging research, clinical trials, and disease diagnosis. ### Competing Interest Statement P.T.G. and D.A.S. are named inventors on a patent application related to TIME-Seq methods filed by Harvard Medical School and licensed to Longevity Sciences. P.T.G. is an equity owner of Longevity Sciences. D.A.S is a consultant to, inventor of patents licensed to, and in some cases board member and investor in MetroBiotech, Cohbar, Life Biosciences and affiliates, Zymo, EdenRoc Sciences and affiliates, Alterity, InsideTracker, Immetas, Segterra, and Galilei Biosciences. He is also an inventor on patent applications licensed to Bayer Crops, Merck KGaA, and Elysium Health. Additional info at sinclair.hms.harvard.edu/david-sinclairs-affiliations. A.T., C.K, V.N.G. are named inventors on a patent application related to scAge filed by Brigham and Women's Hospital. S.J.M, A.E.K, M.R.M and J.R.M. have nothing to disclose.

Scientific Reports - The use of N-acetylcysteine in the prevention of hangover: a randomized trial

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A method to profile hair pigmentation patterns establishes a new approach for psychobiological studies and links metabolic changes to greying in humans.

Nature - The antitumour drug rapamycin targets TOR, a kinase that is part of the PI3K–AKT–mTOR cascade, involved in regulating protein translation, cell growth and autophagy. Reducing...

Interest in the co-occurrence of attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) has grown in the last decade. Research on clinical populations supports the frequent co-occurrence of ADHD traits (e.g., hyperactivity) ...

t and hoarseness. METHODS: One hundred fifty patients, ASA physical status I to II, scheduled to undergo general anesthesia and elective orthopedic or gynecologic surgery were enrolled. Participants were randomly allocated to receive either Strepsils or identical-looking placebo tablets immediately before arrival to the operating room. The incidence and severity of postoperative sore throat and hoarseness were evaluated immediately and 24 hours after surgery. RESULTS: The incidence of early postoperative sore throat was 13.7% and 33.3% and hoarseness was 12.3% and 26.4% in the Strepsils and placebo groups, respectively (P 0.05). One day after surgery, the incidence of sore throat decreased to 6.8% and 18.1% in the Strepsils and control groups, respectively. The incidence of hoarseness 1 day after the operation decreased to 8.2% in the Strepsils group and 19.4% in the placebo group, but the difference remained statistically significant (P 0.05). CONCLUSION: Perioperative use of Strepsils tablets reduces postoperative sore throat and hoarseness of voice....

The burdens imposed by treatment-resistant depression (TRD) necessitate the identification of predictive factors that may improve patient treatment and outcomes. Because depression and attention-deficit hyperactivity disorder (ADHD) are frequently comorbid ...

Magnesium, one of the basic elements for the human body, is necessary for many physiological functions. Magnesium deficiency is widely observed as a result of the reduced nutrient content of foods, over-cooking, diseases, drugs, alcohol, and caffeine consumption. Taking a dietary supplement is neces …

Due to its overwhelmingly positive results, Truehope's EMPowerplus formulation is the most studied micronutrient in the world. While so many multi-vitamin and mineral products have good ingredients, they are formulated in a way that does not allow their c

Periorbital hyperpigmentation is a commonly encountered condition. There is very little scientific data available on the clinical profile and pathogenesis of periorbital hyperpigmentation. Periorbital hyperpigmentation is caused by various exogenous and ...

You can do a lot of prep work to make the perfect sleep environment. But if that doesn’t work, here are six other hacks to try.

4-phosphorloxy-N,N-dimethyltryptamine (psilocybin) and methylenedioxymethamfetamine (MDMA), best known for their illegal use as psychedelic drugs, are…

PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

MDMA and psilocybin researcher Alicia Danforth, Ph.D., talks with Amber Lyon of Reset.Me about her past and ongoing research using psychedelics to increase the effectiveness of therapy for anxiety-related conditions. Danforth highlights her current...

Background: Psychiatric research in the 1950s and 1960s showed potential for psychedelic medications to markedly alleviate depression and suffering associated with terminal illness. More recent published studies have demonstrated the safety and efficacy ...

Want to volunteer for a psychedelic clinical trial? Search in a current list of MDMA, psilocybin, LSD, ketamine, and cannabis studies.

J Sports Sci. 2004 Oct;22(10):946-65; discussion 965-6. Review