Medical research

Aging | doi:10.18632/aging.101250. James A. McCubrey, Kvin Lertpiriyapong, Linda S. Steelman, Steve L. Abrams, Li V. Yang, Ramiro M. Murata, Pedro L. Rosalen, Aurora Scalisi, Luca M. Neri, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Piotr Laidler, Joanna Dulińska-Litewka, Dariusz Rakus, Agnieszka Gizak, Paolo Lombardi, Ferdinando Nicoletti, Saverio Candido, Massimo Libra, Giuseppe Montalto, Melchiorre Cervello

Bacterial lysates, prepared from the microorganisms most frequently involved in human Respiratory Tract Infections (RTIs) have been in the market for several decades, and at present, several different brands are available in many countries worldwide. ...

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Background Allergen specific IgG4 levels have been monitored as a surrogate marker for the tolerance inducing effect of subcutaneous immunotherapy (SCIT) in many studies. Its accuracy at group level has been well established, but IgG4 has not yet found its place in the daily care of immunotherapy patients. Methods Intralymphatic immunotherapy (ILIT) is a novel route for allergy vaccination against pollen allergy, where an ultrasound-guided injection of 1000 SQ-U Alutard is given directly into a groin lymph node. The suggested standard dosing so far has been one injection with 4 weeks in-between. In total 3000 SQ-U with the treatment completed in 2 months. IgG4 was measured with Immulite technique and rhinoconjunctivitis symptoms were estimated with daily online questionnaires. Mann–Whitney U-test and Wilcoxon Signed Rank test were applied for comparisons between groups and within groups, respectively. Results The present study demonstrates that a single, preseason ILIT booster of 1000 SQ-U Alutard 5-grasses®, re-increases the allergen specific timothy-IgG4 levels, in patients already treated with ILIT before the previous pollen season. It also shows the feasibility of the ILIT-route for allergy vaccination of rhinitis patients, with or without concomitant asthma, with low degree of side effects and reconfirms high and sustained patient satisfaction. Conclusions It is tempting to suggest that the allergen specific IgG4 levels can be used to build an intuitive algorithm for future clinical guidance of ILIT patients. Trial registration Is Intralymphatic Allergen Immunotherapy Effective and Safe?, ClinicalTrials.gov Identifier NCT04210193. Registered 24 December 2019—Retrospectively registered, https://clinicaltrials.gov/ct2/show/study/NCT04210193?term=NCT04210193&draw=2&rank=1

That doesn’t stop providers from prescribing it or pharmacies from making it

Consensus processes like the Delphi method are well-meaning, but they are not a substitute for rigorous RCTs with large sample sizes, adequate duration, and standardized outcome measures.

In summary, using a modified Delphi process, expert consensus-based recommendations were developed on how to dose and administer medical cannabis for the treatment of patients with chronic pain.

Blood test CA 125: a rule-in test for the #diagnosis of women presenting with symptoms of #endometriosis. This article includes Author Insights, a video abstract available at https://vimeo.com/rcog/a...

A blog for people with endometriosis discussing the latest Cochrane evidence on blood tests for diagnosing endometriosis

The relation between excessive prolactin and endometriosis-related infertility is debatable. Anovulation or defective luteal phase occurs frequently due to hyperprolactinemia in subfertile women. In this investigation, we evaluated the association between ...

More than ten percent of people suffer from at least one episode of depression and related mental disorders in a lifetime, and depression and related mental disorders are one of the world’s greatest public health problems. A multiple system theory holds that dysregulation of the multiple systems underlies the pathogenesis of depression and related mental disorders, and new therapies based on the multiple system dysregulation theory are urgently needed. In this study, the antidepressant effect of decoction from herbi Cistanche deserticola/i Y.C.Ma andi Cistanche tubulosa/i was examined. Herbi Cistanche/i decoction reduced the immobility period significantly in the mouse tail suspension test. Mice treated with herb decoction showed an improved ability of spatial learning and memory in the Morris water maze test. Groups treated herb decoction displayed a downregulated monoamine oxidase (MAO) activity; the dopamine (DA) concentration in the brain was upregulated, indicating herbi Cistanche/i decoction improved the nerve excitability; the serum concentration of corticosterone (CORT) was downregulated, showing that mice benefited from a reduced stress level. Hence, the antidepressant efficacy and mechanism of traditional Chinese herbi Cistanche/i were explored in this study. Herbi Cistanche/i showed a potential to be developed as a complementary and alternative therapy for depression.

Last week, FDA once again changed course in its approach towards regulating pharmacogenomic (PGx) tests.  We have blogged on this story several times before (see past blog posts here and here).  A …

Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addressing the remaining 8% of the genome, the Telomere-to-Telomere (T2T) ...

Nature Aging - The authors compared muscle metabolomes of young and older adults with different muscle health and physical activity levels. They found that aging was characterized by lower levels...

Gray hair is a visible sign of tissue degeneration during aging. Graying is attributed to dysfunction of melanocyte stem cells (McSCs) that results in depletion of their melanin-producing progeny. Th...

Estrogen has a dramatic effect on musculoskeletal function. Beyond the known relationship between estrogen and bone, it directly affects the structure and function of other musculoskeletal tissues such as muscle, tendon, and ligament. In these other musculoskeletal ...

This article reviews microneurographic research on sympathetic neural control in women under both physiological and pathophysiological conditions across the lifespan. Specifically, the effects of sex, age, race, the menstrual cycle, oral contraceptives, ...

Epigenetic “clocks” based on DNA methylation (DNAme) are the most robust and widely employed aging biomarker. They have been built for numerous species and reflect gold-standard interventions that extend lifespan. However, conventional methods for measuring epigenetic clocks are expensive and low-throughput. Here, we describe Tagmentation-based Indexing for Methylation Sequencing (TIME-Seq) for ultra-cheap and scalable targeted methylation sequencing of epigenetic clocks and other DNAme biomarkers. Using TIME-Seq, we built and validated inexpensive epigenetic clocks based on genomic and ribosomal DNAme in hundreds of mice and human samples. We also discover it is possible to accurately predict age from extremely low-cost shallow sequencing (e.g., 10,000 reads) of TIME-Seq libraries using scAge , a probabilistic age-prediction algorithm originally applied to single cells. Together, these methods reduce the cost of DNAme biomarker analysis by more than two orders of magnitude, thereby expanding and democratizing their use in aging research, clinical trials, and disease diagnosis. ### Competing Interest Statement P.T.G. and D.A.S. are named inventors on a patent application related to TIME-Seq methods filed by Harvard Medical School and licensed to Longevity Sciences. P.T.G. is an equity owner of Longevity Sciences. D.A.S is a consultant to, inventor of patents licensed to, and in some cases board member and investor in MetroBiotech, Cohbar, Life Biosciences and affiliates, Zymo, EdenRoc Sciences and affiliates, Alterity, InsideTracker, Immetas, Segterra, and Galilei Biosciences. He is also an inventor on patent applications licensed to Bayer Crops, Merck KGaA, and Elysium Health. Additional info at sinclair.hms.harvard.edu/david-sinclairs-affiliations. A.T., C.K, V.N.G. are named inventors on a patent application related to scAge filed by Brigham and Women's Hospital. S.J.M, A.E.K, M.R.M and J.R.M. have nothing to disclose.

Scientific Reports - The use of N-acetylcysteine in the prevention of hangover: a randomized trial

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A method to profile hair pigmentation patterns establishes a new approach for psychobiological studies and links metabolic changes to greying in humans.

Nature - The antitumour drug rapamycin targets TOR, a kinase that is part of the PI3K–AKT–mTOR cascade, involved in regulating protein translation, cell growth and autophagy. Reducing...

Interest in the co-occurrence of attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) has grown in the last decade. Research on clinical populations supports the frequent co-occurrence of ADHD traits (e.g., hyperactivity) ...

t and hoarseness. METHODS: One hundred fifty patients, ASA physical status I to II, scheduled to undergo general anesthesia and elective orthopedic or gynecologic surgery were enrolled. Participants were randomly allocated to receive either Strepsils or identical-looking placebo tablets immediately before arrival to the operating room. The incidence and severity of postoperative sore throat and hoarseness were evaluated immediately and 24 hours after surgery. RESULTS: The incidence of early postoperative sore throat was 13.7% and 33.3% and hoarseness was 12.3% and 26.4% in the Strepsils and placebo groups, respectively (P 0.05). One day after surgery, the incidence of sore throat decreased to 6.8% and 18.1% in the Strepsils and control groups, respectively. The incidence of hoarseness 1 day after the operation decreased to 8.2% in the Strepsils group and 19.4% in the placebo group, but the difference remained statistically significant (P 0.05). CONCLUSION: Perioperative use of Strepsils tablets reduces postoperative sore throat and hoarseness of voice....

The burdens imposed by treatment-resistant depression (TRD) necessitate the identification of predictive factors that may improve patient treatment and outcomes. Because depression and attention-deficit hyperactivity disorder (ADHD) are frequently comorbid ...