C Diff Diagnosis

Among adults tested for C. difficile, nucleic acid amplification test positive/toxin negative status was associated with later toxin positivity, though abs

Whole genome sequencing (WGS) of pathogens allows tracking of mutations across populations, enabling mapping of isolate relatedness and supporting detailed u...

spaniClostridioides difficile/i (iC. difficile/i) was a gram-positive anaerobic ibacterium/i in the gut, exhibiting clinical manifestations ranging from mild diarrhoea to fatal pseudomembranous colitis. iC. difficile/i infection (CDI) remains a serious public health problem and accounted/span …

spaniClostridioides difficile/i is a common etiological factor of hospital infections, which, in extreme cases, can lead to the death of patients. Most strains belonging to this bacterium species synthesize very dangerous toxins: toxin A (TcdA) and B (TcdB) and binary toxin (CDT). The aim of this st/span …

Clostridioides difficile is a Gram-positive, spore-forming anaerobic enteropathogen responsible for a wide spectrum of clinical diseases ranging from mild diarrhoea to pseudomembranous colitis. It is the first cause of healthcare-associated diarrhoeas, but community-associated Clostridioides diffici …

Nature Communications - In this study, authors introduce small molecular taxon-specific markers for bacterial detection directly in complex matrices using MS-based (spatial) metabolomics. This...

Request PDF | Adding Virome Capture Metagenomic Sequencing to Conventional Laboratory Testing Increases Unknown Fever Etiology Determination in Bamako, Mali | Unexplained fever poses significant diagnostic challenges in resource-limited settings like Bamako, Mali, where overlapping endemic diseases... | Find, read and cite all the research you need on ResearchGate

Significant variations in CDI and testing rates were observed across the three hospitals. An increase in CDI rates was noted at all centres during the 2020 SARS-CoV-2 outbreak. Advanced age was not prevalent in the cohort, and rCDI rates were relatively low. These findings highlight the need for sys …

For Clostridioides difficile infections, highly sensitive rapid diagnostic test kits are necessary for prompt diagnose and infection control. In this study, we evaluated "Quick Chaser CD GDH/TOX" (evaluation kit), a rapid diagnostic kit for C. difficile, using 65 clinical stool specime …

Clostridioides difficile (C. difficile) was a gram-positive anaerobic bacterium in the gut, exhibiting clinical manifestations ranging from mild diarrhoea to fatal pseudomembranous colitis. C. difficile infection (CDI) remains a serious public health problem and accounted …

This study shows the possibility of rapid discrimination of relevant C. difficile ribotypes by using MALDI-TOF MS. This methodology reduces the time, costs and laboriousness of current reference methods.

This rapid review identified and summarised evidence of the accuracy of new diagnostic tests for Clostridioides difficile (C. difficile).

The laboratory diagnosis of iClostridioides difficile/i infection (CDI) is controversial. Nucleic acid amplification tests (NAAT) and toxin enzyme immunoassays (EIA) are most widely used, often in combination. However, the interpretation of a positive NAAT and negative toxin immunoassay (NAAT+/E …

The German firm said that it plans to launch its AltoStar Parvovirus B19 PCR Kit 1.5 in January and other unspecified tests through spring of 2025.

spaniClostridioides difficile/i species lacking toxin genes (non-toxigenic iC. difficile/i or NTCD) may confer protection against CDI. However, current diagnostic tests detect either toxin proteins or toxin genes and cannot detect NTCD. This study developed a molecular testing method that unique/span …

ClinicalTrials.gov Identifier: NCT04078594.

Reimbursement for molecular syndromic panel testing for UTI may continue to face uncertainty.

TEHRAN (ANA)- Iranian researchers from University of Tehran succeeded in developing and designing an electrochemical genosensor to identify different strains of the C. difficile bacteria with high sensitivity and accuracy.

The gut microbiota might perhaps one day become a routine tool for the early diagnosis of many diseases and to guide treatment, but at present there

Researchers found that removing Clostridioides difficile from gastrointestinal pathogen panels reduced unnecessary treatment without causing delays in diagnosis.

Diagnosis of Clostridioides difficile infection (CDI) remains challenging as it involves in the first instance recognition (clinical awareness) of the patients' symptoms for clinical suspicion of CDI to warrant testing, and secondly, different laboratory tests have been described for CDI. Due …

Investigators were seeking clarification on optimal sequencing of the immune checkpoint inhibitor atezolizumab following treatment failure and disease progression after receipt of nivolumab and pembrolizumab.

Current guidelines recommend a two-step algorithm rather than relying solely on a single test for diagnosing Clostridioides difficile infection. This algorithm starts with enzyme immunoassay (EIA) for detecting glutamate dehydrogenase (GDH) and toxins A/B, followed by nucleic acid amplificati …

The detection of C. difficile in a much high number of these samples by shotgun metagenomics, albeit at low levels of relative abundance, suggests that neither of these culture protocols is sensitive when levels of abundance are low.

Clostridioides difficile became one of the main causes of nosocomial infections in all clinical settings worldwide, especially among patients undergoing antibiotic therapy. The incidence and severity of C. difficile infections, from mild diarrhea to life-threatening pseudomembranous co …

Paul Feuerstadt, MD, FACG, AGAF, discusses how testing for Clostridioides difficile is recommended for hospitalized patients or outpatients with new-onset, unexplained diarrhea who have risk factors such as recent antibiotic use, hospitalization, or older age, and how empiric treatment should be initiated while awaiting test results if there is high clinical suspension.

Removing C. difficile from the GIPP resulted in effective diagnostic and antimicrobial stewardship without resulting in delayed diagnoses.

An Unusual Cause of Diarrhea and Hematochezia

Target product profiles (TPPs) for new medical tests provide test developers with performance benchmarks and technical requirements for new tests. Early economic evaluation has already been used to identify acceptable ranges for certain performance requirements for new tests. Currently, however, ear …