C Diff Diagnosis

C Diff Diagnosis

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Model-based cost-impact analysis of a diagnostic test for patients with community-acquired pneumonia in Canada - BMC Infectious Diseases
Model-based cost-impact analysis of a diagnostic test for patients with community-acquired pneumonia in Canada - BMC Infectious Diseases
Background Antibiotics are broadly prescribed for community-acquired pneumonia (CAP) despite being only effective for bacterial infections. LIAISON® MeMed BV® (LMMBV) is a novel diagnostic test that can support clinicians in differentiating bacterial from viral infections and guide diagnostic-driven antibiotic prescribing. Methods We developed a cost-impact model to compare the clinical and economic outcomes of using LMMBV with the current standard of care (SOC) versus SOC alone among a hypothetical cohort of 1,000 CAP patients presenting to the emergency department. The analysis was conducted from a Canadian public health payer’s perspective. Outcomes of interest included antibiotic use (number of patients and days saved), hospital admission (admissions avoided and days saved), intensive care unit admission, adverse events, and clostridium difficile infection. One-way sensitivity analyses were conducted to explore parameter uncertainty. Scenario analyses were conducted according to age group, province, and impact of LMMBV on hospitalization. Results In the base case, LMMBV plus SOC reduced the number of patients prescribed antibiotic treatment (429 patients avoided) and the total number of antibiotic treatment days (1,020 days avoided). The per-patient cost savings were $504.96 compared to SOC alone. These findings were consistent across all sensitivity and scenario analyses. Assuming full adoption of LMMBV, the per patient cost savings are projected to result in more than $163 million in total savings annually in Canada based on population estimates and published incidence data. Conclusion Considering the burden of CAP and antimicrobial resistance to the health care system, the use of LMMBV with SOC can offer both clinical and economic benefits to Canadian public payers.
·bmcinfectdis.biomedcentral.com·
Model-based cost-impact analysis of a diagnostic test for patients with community-acquired pneumonia in Canada - BMC Infectious Diseases
Predicting positive Clostridioides difficile test results using large-scale longitudinal data of demographics and medication history - PubMed
Predicting positive Clostridioides difficile test results using large-scale longitudinal data of demographics and medication history - PubMed
The models achieve high discrimination performance (AUROC 0.83). There is a general consensus among different analysis approaches regarding predictors that impact patients' chances of having a positive test, which may influence iClostridioides difficile/i risk, including features clinically …
·pubmed.ncbi.nlm.nih.gov·
Predicting positive Clostridioides difficile test results using large-scale longitudinal data of demographics and medication history - PubMed
SOLARIS project: a portable 3D-printed bioaerosol sampler for environmental bacterial collection - PubMed
SOLARIS project: a portable 3D-printed bioaerosol sampler for environmental bacterial collection - PubMed
Bioaerosols, a subset of aerosols released from the biosphere, can carry pathogens, and include particles with diameters from nanometres to a few micrometres. They can remain suspended indoors and travel significant distances. Bioaerosol studies play a vital role in public health, as bioaerosols are …
·pubmed.ncbi.nlm.nih.gov·
SOLARIS project: a portable 3D-printed bioaerosol sampler for environmental bacterial collection - PubMed
Defining Fulminant Clostridioides difficile Infections: Assessing the Utility of Hypotension as a Diagnostic Criterion - PubMed
Defining Fulminant Clostridioides difficile Infections: Assessing the Utility of Hypotension as a Diagnostic Criterion - PubMed
Inclusion of hypotension, defined as SBP ≤90 mm Hg or MAP ≤65 mm Hg, was an important component of FCDI severity criteria, significantly improving the predictive ability to identify FCDI patients at risk for poor outcomes.
·pubmed.ncbi.nlm.nih.gov·
Defining Fulminant Clostridioides difficile Infections: Assessing the Utility of Hypotension as a Diagnostic Criterion - PubMed
Cyclospora cayetanensis or Clostridium difficile: Who Caused the Diarrhea? - PubMed
Cyclospora cayetanensis or Clostridium difficile: Who Caused the Diarrhea? - PubMed
Cyclospora cayetanensis, a parasite causing human enteritis, has been rarely reported from healthcare laboratories despite its universal presence. While it is usually responsible for self-limiting diarrhea in immunocompetent individuals, we present a case where the patient suffered from severe, unre …
·pubmed.ncbi.nlm.nih.gov·
Cyclospora cayetanensis or Clostridium difficile: Who Caused the Diarrhea? - PubMed
Antimicrobial susceptibility testing of Clostridioides difficile: a dual-site study of three different media and three therapeutic antimicrobials - PubMed
Antimicrobial susceptibility testing of Clostridioides difficile: a dual-site study of three different media and three therapeutic antimicrobials - PubMed
This study shows medium-dependent differences in C. difficile MICs for at least two antimicrobials across two sites. We suggest the use of FAA-HB to align with general EUCAST recommendations for susceptibility testing of anaerobic bacteria and deposited reference strains for standard susceptibility …
·pubmed.ncbi.nlm.nih.gov·
Antimicrobial susceptibility testing of Clostridioides difficile: a dual-site study of three different media and three therapeutic antimicrobials - PubMed
Can Gut Microbiota Analysis Reveal Clostridioides difficile Infection? Evidence from an Italian Cohort at Disease Onset - PubMed
Can Gut Microbiota Analysis Reveal Clostridioides difficile Infection? Evidence from an Italian Cohort at Disease Onset - PubMed
A diverse and well-functioning gut microbiota normally serves as a protective shield against the invasion of harmful bacteria or the proliferation of opportunistic pathogens. iClostridioides difficile/i infection (CDI) is predominantly associated with the overuse of antibiotics, resulting in a s …
·pubmed.ncbi.nlm.nih.gov·
Can Gut Microbiota Analysis Reveal Clostridioides difficile Infection? Evidence from an Italian Cohort at Disease Onset - PubMed
Inflammatory Markers and Severity in COVID-19 Patients with Clostridioides Difficile Co-Infection: A Retrospective Analysis Including Subgroups with Diabetes, Cancer, and Elderly - PubMed
Inflammatory Markers and Severity in COVID-19 Patients with Clostridioides Difficile Co-Infection: A Retrospective Analysis Including Subgroups with Diabetes, Cancer, and Elderly - PubMed
Concurrent CDI intensifies systemic inflammation and adverse clinical trajectories in hospitalized COVID-19 patients. Elevations in inflammatory markers and severity scores predict worse outcomes, especially in high-risk subgroups. Early recognition and targeted interventions, including infection co …
·pubmed.ncbi.nlm.nih.gov·
Inflammatory Markers and Severity in COVID-19 Patients with Clostridioides Difficile Co-Infection: A Retrospective Analysis Including Subgroups with Diabetes, Cancer, and Elderly - PubMed
Advances in diagnostic assays for Clostridioides difficile infection in adults - PubMed
Advances in diagnostic assays for Clostridioides difficile infection in adults - PubMed
spaniClostridioides difficile/i (iC. difficile/i) was a gram-positive anaerobic ibacterium/i in the gut, exhibiting clinical manifestations ranging from mild diarrhoea to fatal pseudomembranous colitis. iC. difficile/i infection (CDI) remains a serious public health problem and accounted/span …
·pubmed.ncbi.nlm.nih.gov·
Advances in diagnostic assays for Clostridioides difficile infection in adults - PubMed
The Use of Gel Electrophoresis to Separate Multiplex Polymerase Chain Reaction Amplicons Allows for the Easy Identification and Assessment of the Spread of Toxigenic Clostridioides difficile Strains - PubMed
The Use of Gel Electrophoresis to Separate Multiplex Polymerase Chain Reaction Amplicons Allows for the Easy Identification and Assessment of the Spread of Toxigenic Clostridioides difficile Strains - PubMed
spaniClostridioides difficile/i is a common etiological factor of hospital infections, which, in extreme cases, can lead to the death of patients. Most strains belonging to this bacterium species synthesize very dangerous toxins: toxin A (TcdA) and B (TcdB) and binary toxin (CDT). The aim of this st/span …
·pubmed.ncbi.nlm.nih.gov·
The Use of Gel Electrophoresis to Separate Multiplex Polymerase Chain Reaction Amplicons Allows for the Easy Identification and Assessment of the Spread of Toxigenic Clostridioides difficile Strains - PubMed
[Clostridioides difficile infection diagnosis] - PubMed
[Clostridioides difficile infection diagnosis] - PubMed
Clostridioides difficile is a Gram-positive, spore-forming anaerobic enteropathogen responsible for a wide spectrum of clinical diseases ranging from mild diarrhoea to pseudomembranous colitis. It is the first cause of healthcare-associated diarrhoeas, but community-associated Clostridioides diffici …
·pubmed.ncbi.nlm.nih.gov·
[Clostridioides difficile infection diagnosis] - PubMed
Adding Virome Capture Metagenomic Sequencing to Conventional Laboratory Testing Increases Unknown Fever Etiology Determination in Bamako, Mali | Request PDF
Adding Virome Capture Metagenomic Sequencing to Conventional Laboratory Testing Increases Unknown Fever Etiology Determination in Bamako, Mali | Request PDF
Request PDF | Adding Virome Capture Metagenomic Sequencing to Conventional Laboratory Testing Increases Unknown Fever Etiology Determination in Bamako, Mali | Unexplained fever poses significant diagnostic challenges in resource-limited settings like Bamako, Mali, where overlapping endemic diseases... | Find, read and cite all the research you need on ResearchGate
·researchgate.net·
Adding Virome Capture Metagenomic Sequencing to Conventional Laboratory Testing Increases Unknown Fever Etiology Determination in Bamako, Mali | Request PDF
Clostridioides difficile Infection and Testing Rates in South Africa: A multicentre study, 2017-2020 - PubMed
Clostridioides difficile Infection and Testing Rates in South Africa: A multicentre study, 2017-2020 - PubMed
Significant variations in CDI and testing rates were observed across the three hospitals. An increase in CDI rates was noted at all centres during the 2020 SARS-CoV-2 outbreak. Advanced age was not prevalent in the cohort, and rCDI rates were relatively low. These findings highlight the need for sys …
·pubmed.ncbi.nlm.nih.gov·
Clostridioides difficile Infection and Testing Rates in South Africa: A multicentre study, 2017-2020 - PubMed
[Evaluation of Quick Chaser CD GDH/TOX, a Rapid Diagnostic Kit for Simultaneous Detection of Clostridioides difficile Antigen and Toxin A/B, in Fecal Specimens] - PubMed
[Evaluation of Quick Chaser CD GDH/TOX, a Rapid Diagnostic Kit for Simultaneous Detection of Clostridioides difficile Antigen and Toxin A/B, in Fecal Specimens] - PubMed
For Clostridioides difficile infections, highly sensitive rapid diagnostic test kits are necessary for prompt diagnose and infection control. In this study, we evaluated "Quick Chaser CD GDH/TOX" (evaluation kit), a rapid diagnostic kit for C. difficile, using 65 clinical stool specime …
·pubmed.ncbi.nlm.nih.gov·
[Evaluation of Quick Chaser CD GDH/TOX, a Rapid Diagnostic Kit for Simultaneous Detection of Clostridioides difficile Antigen and Toxin A/B, in Fecal Specimens] - PubMed
Advances in diagnostic assays for Clostridioides difficile infection in adults - PubMed
Advances in diagnostic assays for Clostridioides difficile infection in adults - PubMed
Clostridioides difficile (C. difficile) was a gram-positive anaerobic bacterium in the gut, exhibiting clinical manifestations ranging from mild diarrhoea to fatal pseudomembranous colitis. C. difficile infection (CDI) remains a serious public health problem and accounted …
·pubmed.ncbi.nlm.nih.gov·
Advances in diagnostic assays for Clostridioides difficile infection in adults - PubMed
Analysis of high-molecular-weight proteins using MALDI-TOF MS and machine learning for the differentiation of clinically relevant Clostridioides difficile ribotypes - PubMed
Analysis of high-molecular-weight proteins using MALDI-TOF MS and machine learning for the differentiation of clinically relevant Clostridioides difficile ribotypes - PubMed
This study shows the possibility of rapid discrimination of relevant C. difficile ribotypes by using MALDI-TOF MS. This methodology reduces the time, costs and laboriousness of current reference methods.
·pubmed.ncbi.nlm.nih.gov·
Analysis of high-molecular-weight proteins using MALDI-TOF MS and machine learning for the differentiation of clinically relevant Clostridioides difficile ribotypes - PubMed
Clostridioides difficile diagnostic test accuracy
Clostridioides difficile diagnostic test accuracy
This rapid review identified and summarised evidence of the accuracy of new diagnostic tests for Clostridioides difficile (C. difficile).
·gov.uk·
Clostridioides difficile diagnostic test accuracy
Clinical significance of toxin EIA positivity in patients with suspected Clostridioides difficile infection: systematic review and meta-analysis - PubMed
Clinical significance of toxin EIA positivity in patients with suspected Clostridioides difficile infection: systematic review and meta-analysis - PubMed
The laboratory diagnosis of iClostridioides difficile/i infection (CDI) is controversial. Nucleic acid amplification tests (NAAT) and toxin enzyme immunoassays (EIA) are most widely used, often in combination. However, the interpretation of a positive NAAT and negative toxin immunoassay (NAAT+/E …
·pubmed.ncbi.nlm.nih.gov·
Clinical significance of toxin EIA positivity in patients with suspected Clostridioides difficile infection: systematic review and meta-analysis - PubMed
A quantitative PCR to detect non-toxigenic Clostridioides difficile - PubMed
A quantitative PCR to detect non-toxigenic Clostridioides difficile - PubMed
spaniClostridioides difficile/i species lacking toxin genes (non-toxigenic iC. difficile/i or NTCD) may confer protection against CDI. However, current diagnostic tests detect either toxin proteins or toxin genes and cannot detect NTCD. This study developed a molecular testing method that unique/span …
·pubmed.ncbi.nlm.nih.gov·
A quantitative PCR to detect non-toxigenic Clostridioides difficile - PubMed
Experts Call for Order in Gut Microbiota Testing
Experts Call for Order in Gut Microbiota Testing
The gut microbiota might perhaps one day become a routine tool for the early diagnosis of many diseases and to guide treatment, but at present there
·miragenews.com·
Experts Call for Order in Gut Microbiota Testing