C Diff Diagnosis

Detection of Clostridioides difficile toxins in patients with gastroenteritis has increasingly been accomplished through the use of enteric multiplex syndromic panels. Comparisons of the performance of these panels to both direct-from-stool (DFS) and culture-enriched stools followed by polyme …

Detection of Clostridioides difficile toxins in patients with gastroenteritis has increasingly been accomplished through the use of enteric multiplex syndromic panels. Comparisons of the performance of these panels to both direct-from-stool (DFS) and culture-enriched stools followed by polyme …

Using only an electronic health record intervention, we successfully decreased C. difficile orders after 72 hours of admission in a large, safety-net system. Variation existed among hospitals and by provider type.

Northwestern Medicine developed a testing strategy using a two-step algorithm to improve diagnostic accuracy and treatment outcomes.

Northwestern Medicine developed a testing strategy using a two-step algorithm to improve diagnostic accuracy and treatment outcomes.

We developed and validated a set of fully automated surveillance algorithms for healthcare-onset CDI using electronic health records. In a validation data set of 750 manually annotated admissions, the algorithm based on International Classification of Disease, Tenth Revision (ICD-10) code A04 …

Dr. Abraham discusses importance of differential diagnosis of C. difficile infection (CDI) in patients with IBD and how both IBD and CDI should be managed.

Drs. Abraham, Chopra and Feuerstadt discuss importance of timely referral and diagnostic methods to discern C. difficile infection (CDI).

Clostridium Difficile Diagnostics and Treatment Market Insights, and Upcoming Business Opportunities 2022-2030 By Stratagem Market Insights the extensive research on Clostridium Difficile Diagnostics and Treatment Market is a clear picture of all the essential factors that are expected to drive the market considerably. A thorough study of the Market helps the buyers of the report, customers, […]

The C. DIFF QUIK CHEK COMPLETE, in a two-step approach with the Xpert C. difficile, performed similarly to the NAATs on their own and offer advantages in terms of cost and workflow in low-resource settings.

Bundled interventions focused on appropriate C. difficile testing can result in a significant decrease in testing and clinical diagnosis of C. difficile infection without any harms related to delay in diagnosis. In otherwise stable renal transplant recipients after the first month of transplant, scr …

Agree -good data & @ESCMID guidelines - test all - don’t wait to be asked - missing #cdiff puts other patients at risk of cross infection @RCSI_Micro @EdKuijper2 @kerrieanndavies https://t.co/BkVbXYxuqf— Prof. Fidelma Fitzpatrick (@FfitzP) October 17, 2022

Elevated MICs to antibiotics used for treatment of C. difficile infection were rare and there was no increase in MICs over time. The lack of vanA/B genes or mutations consistently associated with elevated vancomycin MICs suggests there are multifactorial mechanisms of resistance. Ongoing surveillanc …

Dr. Abraham discusses importance of differential diagnosis of C. difficile infection (CDI) in patients with IBD and how both IBD and CDI should be managed.

Determinates of Clostridioides difficile infection (CDI) testing practices among inpatients with diarrhea at selected acute-care hospitals in Rochester, New York, and Atlanta, Georgia, 2020–2021

Accounting for patient-specific factors that influence CDI test ordering, differences in testing practices between sites remain and likely contribute to regional differences in surveillance estimates.

Dr. Abraham discusses importance of differential diagnosis of C. difficile infection (CDI) in patients with IBD and how both IBD and CDI should be managed.

You don't usually need to see a doctor for gastroenteritis, but if you seek medical care, you may wonder if labs tests are needed. This article covers gastroenteritis lab tests.

Hospital-acquired infections at Southern Ohio Medical Center in Portsmouth have fallen since it implemented a software program from Meditech, the EHR vendor said Aug. 30.

The developed protocol allows prospective and retrospective molecular and genomic epidemiological investigation of C. difficile infections for infection control purpose.

Heralding in a new frontier of research and treatment: Inside the Microbiome Founded in 2012, the U of M intestinal microbiota donor program was the first of its kind worldwide. Over 1000 patients have received IMT free of charge through the program. Over 100,000 patients have benefited from the protocols established through the U of M Microbiota Therapeutics Program. In medicine, we know that treating one symptom may set off a chain event that causes unintended consequences. Antibiotic treatments, vital for treating bacterial conditions, can destroy some of the 100 trillion bacterial cells in your intestine, leading to C. difficile, a disease that can be fatal to older adults or those with comprised immune systems. As the use of antibiotics continues to rise, we are seeing C. diff infection rates increasing as well. The CDC estimates that C. diff causes 14,000 deaths yearly, with a total cost in the US of $6.3 billion. Even more perplexing to researchers is that antibiotics are the standard of care for treating C. diff. The University of Minnesota Medical School has been leading innovative work in this area through its Microbiota Therapeutics Program (MTP)- the first of its kind worldwide. Founded in 2008, the MTP is a new frontier of medicine that uses next-generation microbiota-based therapeutics to treat C. diff and other diseases. In 2012, Dr. Alexander Khourts, Professor of Medicine in the Division of Gastroenterology, Hepatology and Nutrition, performed the first microbiota transplant via colonoscopy. Since then, the treatment has evolved into a 5 capsule protocol that has shown a 98% success rate in treating C. diff infections. The University of Minnesota’s Molecular & Cellular Therapeutics facility now supplies these capsules to OpenBiome, a nonprofit dedicated to expanding safe access to IMT to catalyze research into the human microbiome. In June 2022, research published in Clinical Infectious Diseases found that IMT is an optimal cost-effective treatment for first recurrent C. diff infection, going against the current standard of care that uses antibiotics to treat this disease. IMT is currently a last resort for people with recurrent C. diff. The University of Minnesota Microbiota Therapeutics Program is hoping to change this for patients and their families, building off of our strengths in basic sciences and immunology to explore this new frontier. By the Numbers 1000+ IMTs performed; 98% success rate; 20,000+ IMT capsules produced; $0 cost to patients. Current clinical trials using IMT: Leukemia A Randomized Placebo-Controlled Clinical Trial of Fecal Microbiota Transplantation in Patients With Acute Myeloid Leukemia and Allogeneic Hematopoietic Cell Transplantation Recipients. Ulcerative Colitis This study examines how daily IMT capsules from healthy individuals with low or undetectable amounts of the bacteria that create H2S affect ulcerative colitis. The main goal of the study is to see if we can change the gut bacteria to decrease H2S production. Liver Disease Fecal Microbiota Transplant in veterans with Cirrhosis. Autism Spectrum Disorder Investigating Microbiota Transfer Therapy (MTT) for treating children with Autism Spectrum Disorder (ASD) and gastrointestinal problems (primarily constipation and/or diarrhea). Solid Organ Transplant Recipients and C.Diff Fecal Microbiota Transplantation for C. Difficile infection in solid organ transplant recipients. Pitt Hopkins Syndrome Investigating Microbiota Transfer Therapy (MTT) for treating patients with Pitt Hopkins Syndrome (PTHS) and gastrointestinal problems similar to Irritable Bowel Syndrome (IBS). Lung Cancer This is a randomized, active-controlled, parallel-group, double-blind Phase II trial, of oral restorative microbiota therapy (RMT) or placebo combined with intravenous (IV) durvalumab (MEDI4736) plus chemotherapy in patients with treatment naïve advanced or metastatic adenocarcinoma non-small cell lung cancer (NSCLC). A Deadly Germ & The Dynamic Duo with a Promising Therapy Amanda Kabage finally had an accurate diagnosis after months and months of debilitating diarrhea. The University of Minnesota researcher suffered from Clostridium difficile infection (C. diff). Amanda, 32 at the time, did what any scientist would do: Investigate the disease that had sidelined this avid runner and world traveler. She was excited when she learned that Dr. Alexander Khoruts, a gastroenterologist at the U of MN, pioneers a highly effective treatment—a microbiota transplant. Watch the Story Video of Gut Ecosystem Restoration via Fecal Transplantation Visual representation of healthy microbiomes vs. C.diff infected microbiome University of Minnesota BioTechnology Institute

Drs. Abraham, Chopra and Feuerstadt discuss importance of timely referral and diagnostic methods to discern C. difficile infection (CDI).

Researchers assessed whether the COVID-19 pandemic influenced the annual incidence of Clostridioides difficile infections among patients in the Netherlands.

The study aimed to identify colonized patients as a possible source of eventual VRE (vancomycin-resistant enterococci) infection from stool samples positive for glutamate dehydrogenase antigen, as well as for Clostridioides difficile toxins A and B. The study was carried out from 7/2020 to 9/2021. S …

Advances in Therapy - Irritable bowel syndrome with diarrhea (IBS-D) is a chronic disorder of gut–brain interaction, characterized by recurrent abdominal pain in association with more...

Diagnostic stewardship has proven effective in reducing C diff infections. We need diagnostic stewardship for other hospital acquired infections as well.

Stool concentrations of the inflammasome pathway, pro-inflammatory cytokine IL-1β can accurately differentiate CDI from asymptomatic carriage and non-CDI diarrhea, making it a promising biomarker for CDI diagnosis. Significant positive correlations exist between stool toxins and stool IL-1β in CDI b …

The epidemiology of Clostridioides difficile infection (CDI) has changed over the last two decades, due to the emergence of C. difficile strains with clinical relevance and responsible for nosocomial outbreaks with severe outcomes. This study reports an outbreak occurred in a Long-term …