C Diff Diagnosis

C Diff Diagnosis

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Comparative evaluation of the detection rate, workflow and associated costs of a multiplex PCR panel versus conventional methods in diagnosis of infectious gastroenteritis - PubMed
Comparative evaluation of the detection rate, workflow and associated costs of a multiplex PCR panel versus conventional methods in diagnosis of infectious gastroenteritis - PubMed
Introduction. Infectious gastroenteritis is a common reason for consulting a physician. Although most cases of gastrointestinal illness are self-limiting, the identification of the etiologic pathogen by stool specimen analysis is important in cases of more severe illness and for epidemiologic …
·pubmed.ncbi.nlm.nih.gov·
Comparative evaluation of the detection rate, workflow and associated costs of a multiplex PCR panel versus conventional methods in diagnosis of infectious gastroenteritis - PubMed
Gastrointestinal PCR panel results and antibiotic use in acute gastroenteritis cases: How appropriate are we in our usage? - PubMed
Gastrointestinal PCR panel results and antibiotic use in acute gastroenteritis cases: How appropriate are we in our usage? - PubMed
The utilization of GI PCR panels in AGE patients has revolutionized the field of diagnostics by providing rapid and accurate identification of pathogens. In units without the possibility of GI PCR testing, CRP, procalcitonin, CRP/albumin ratio and procalcitonin/albumin ratio may be useful in the dec …
·pubmed.ncbi.nlm.nih.gov·
Gastrointestinal PCR panel results and antibiotic use in acute gastroenteritis cases: How appropriate are we in our usage? - PubMed
Rapid discrimination between clinical Clostridioides difficile infection and colonization by quantitative detection of TcdB toxin using a real-time cell analysis system - PubMed
Rapid discrimination between clinical Clostridioides difficile infection and colonization by quantitative detection of TcdB toxin using a real-time cell analysis system - PubMed
This study explored the novel application of the RTCA assay in effectively discerning clinical CDI from CDC cases.
·pubmed.ncbi.nlm.nih.gov·
Rapid discrimination between clinical Clostridioides difficile infection and colonization by quantitative detection of TcdB toxin using a real-time cell analysis system - PubMed
Culture-independent detection of low-abundant Clostridioides difficile in environmental DNA via PCR - PubMed
Culture-independent detection of low-abundant Clostridioides difficile in environmental DNA via PCR - PubMed
Clostridioides difficile represents a major burden to public health. As a well-known nosocomial pathogen whose occurrence is highly associated with antibiotic treatment, most examined C. difficile strains originated from clinical specimen and were isolated under selective conditions em …
·pubmed.ncbi.nlm.nih.gov·
Culture-independent detection of low-abundant Clostridioides difficile in environmental DNA via PCR - PubMed
Rapid Isothermal Detection of Pathogenic Clostridioides difficile Using Recombinase Polymerase Amplification - PubMed
Rapid Isothermal Detection of Pathogenic Clostridioides difficile Using Recombinase Polymerase Amplification - PubMed
Nosocomial-associated diarrhea due to Clostridioides difficile infection (CDI) is diagnosed after sample precultivation by the detection of the toxins in enzyme immunoassays or via toxin gene nucleic acid amplification. Rapid and direct diagnosis is important for targeted treatment to prevent …
·pubmed.ncbi.nlm.nih.gov·
Rapid Isothermal Detection of Pathogenic Clostridioides difficile Using Recombinase Polymerase Amplification - PubMed
Microscopy methods for Clostridioides difficile - PubMed
Microscopy methods for Clostridioides difficile - PubMed
Microscopic technologies including light and fluorescent, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and cryo-electron microscopy have been widely utilized to visualize Clostridioides difficile at the molecular, cellular, community, and structural biology level. This …
·pubmed.ncbi.nlm.nih.gov·
Microscopy methods for Clostridioides difficile - PubMed
Multicenter evaluation of BioCode GPP for syndromic molecular detection of gastrointestinal pathogens from stool specimens - PubMed
Multicenter evaluation of BioCode GPP for syndromic molecular detection of gastrointestinal pathogens from stool specimens - PubMed
Acute gastroenteritis (AGE) is a leading cause of morbidity and mortality worldwide across all age groups that disproportionally affects young children in low- and middle-income countries and immunocompromised patients in high-income countries. Regional outbreaks of AGE are typically detected by tra …
·pubmed.ncbi.nlm.nih.gov·
Multicenter evaluation of BioCode GPP for syndromic molecular detection of gastrointestinal pathogens from stool specimens - PubMed
Rapid discrimination between clinical Clostridioides difficile infection and colonization by quantitative detection of TcdB toxin using a real-time cell analysis system - PubMed
Rapid discrimination between clinical Clostridioides difficile infection and colonization by quantitative detection of TcdB toxin using a real-time cell analysis system - PubMed
This study explored the novel application of the RTCA assay in effectively discerning clinical CDI from CDC cases.
·pubmed.ncbi.nlm.nih.gov·
Rapid discrimination between clinical Clostridioides difficile infection and colonization by quantitative detection of TcdB toxin using a real-time cell analysis system - PubMed
Potential underreporting of treated patients using a Clostridioides difficile testing algorithm that screens with a nucleic acid amplification test - PubMed
Potential underreporting of treated patients using a Clostridioides difficile testing algorithm that screens with a nucleic acid amplification test - PubMed
Use of this 2-step algorithm likely results in underreporting of some NAAT+/toxin- cases with clinically relevant CDI. Disease severity and laboratory interpretive comments influence treatment decisions for NAAT+/toxin- cases.
·pubmed.ncbi.nlm.nih.gov·
Potential underreporting of treated patients using a Clostridioides difficile testing algorithm that screens with a nucleic acid amplification test - PubMed
A new toxin toolkit for C. diff
A new toxin toolkit for C. diff
Clostridioides difficile (C. diff) is a leading cause of diarrhea and healthcare-associated infections in the United States and recognized as an urgent threat by the Centers for Disease Control. Virulence of C. diff infections is believed to rely primarily on the production of two toxins: TcdA and TcdB. TcdA and TcdB are large homologous proteins...
·news.google.com·
A new toxin toolkit for C. diff
A Streamlined Method to Obtain Biologically Active TcdA and TcdB Toxins from Clostridioides difficile - PubMed
A Streamlined Method to Obtain Biologically Active TcdA and TcdB Toxins from Clostridioides difficile - PubMed
The major virulence factors of Clostridioides difficile (C. difficile) are enterotoxins A (TcdA) and B (TcdB). The study of toxins is a crucial step in exploring the virulence of this pathogen. Currently, the toxin purification process is either laborious and time-consuming in C. di …
·pubmed.ncbi.nlm.nih.gov·
A Streamlined Method to Obtain Biologically Active TcdA and TcdB Toxins from Clostridioides difficile - PubMed
A monoclonal antibody collection for C. difficile typing ? - PubMed
A monoclonal antibody collection for C. difficile typing ? - PubMed
Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in adults. Various C. difficile strains circulate currently, associated with different outcomes and antibiotic resistance profiles. However, most studies still focus on the reference strain 6 …
·pubmed.ncbi.nlm.nih.gov·
A monoclonal antibody collection for C. difficile typing ? - PubMed
Using whole genome sequencing to characterize Clostridioides difficile isolates at a tertiary center in Melbourne, Australia - PubMed
Using whole genome sequencing to characterize Clostridioides difficile isolates at a tertiary center in Melbourne, Australia - PubMed
In both study periods, most C. difficile isolates were not closely related, suggesting varied sources of acquisition and that spread of C. difficile within the hospital was unlikely. Current infection control precautions may therefore warrant review. Underlying risk factors for CDI wer …
·pubmed.ncbi.nlm.nih.gov·
Using whole genome sequencing to characterize Clostridioides difficile isolates at a tertiary center in Melbourne, Australia - PubMed
[Evaluation of the Clinical Validity of the Clostridioides difficile Nucleic Acid Detection Kit "Smart Gene® CD ToxinB"] - PubMed
[Evaluation of the Clinical Validity of the Clostridioides difficile Nucleic Acid Detection Kit "Smart Gene® CD ToxinB"] - PubMed
Clostridioides difficile is the most common anaerobic bacterium that causes healthcare-associated infections, and prompt diagnosis and infection control are important because it causes C. difficile infection (CDI). In this evaluation, the C. difficile nucleic acid detection reagent, Sm …
·pubmed.ncbi.nlm.nih.gov·
[Evaluation of the Clinical Validity of the Clostridioides difficile Nucleic Acid Detection Kit "Smart Gene® CD ToxinB"] - PubMed
A Rare Case of Polymerase Chain Reaction-Negative Severe Clostridioides difficile Infection - PubMed
A Rare Case of Polymerase Chain Reaction-Negative Severe Clostridioides difficile Infection - PubMed
Accurately diagnosing Clostridioides difficile infection (CDI) is crucial for effective patient management. A misdiagnosis poses risks to patients, leads to treatment delays, and contributes to infection transmission in healthcare settings. While using polymerase chain reaction (PCR) to ampli …
·pubmed.ncbi.nlm.nih.gov·
A Rare Case of Polymerase Chain Reaction-Negative Severe Clostridioides difficile Infection - PubMed
Diagnostic Guidance for C. difficile Infections - PubMed
Diagnostic Guidance for C. difficile Infections - PubMed
Diagnosis of Clostridioides difficile infection (CDI) can be challenging. First of all, there has been debate on which of the two reference assays, cell cytotoxicity neutralization assay (CCNA) or toxigenic culture (TC), should be considered the gold standard for CDI detection. Although the CCNA suf …
·pubmed.ncbi.nlm.nih.gov·
Diagnostic Guidance for C. difficile Infections - PubMed
Prevalence of toxigenic Clostridium difficile in hospitalized patients in the southwestern province of Saudi Arabia: Confirmation using the GeneXpert analysis - PubMed
Prevalence of toxigenic Clostridium difficile in hospitalized patients in the southwestern province of Saudi Arabia: Confirmation using the GeneXpert analysis - PubMed
Clostridium difficile (Clostridioides difficile) is a leading cause of nosocomial infections in hospitalized patients worldwide. Stool samples were collected from 112 inpatients admitted to different hospitals and were screened for C. difficile GDH + toxin A + B by immunoassay, …
·pubmed.ncbi.nlm.nih.gov·
Prevalence of toxigenic Clostridium difficile in hospitalized patients in the southwestern province of Saudi Arabia: Confirmation using the GeneXpert analysis - PubMed
Comparison of Clostridioides difficile nucleic acid amplification test (NAAT) results using fresh and frozen stool specimens and rectal swabs - PubMed
Comparison of Clostridioides difficile nucleic acid amplification test (NAAT) results using fresh and frozen stool specimens and rectal swabs - PubMed
Nucleic acid amplification tests (NAATs) are frequently used in Clostridioides difficile research and diagnostic testing, but the effect of freezing specimens on C. difficile NAAT performance is not well characterized. This study evaluated the concordance of NAAT results between fresh …
·pubmed.ncbi.nlm.nih.gov·
Comparison of Clostridioides difficile nucleic acid amplification test (NAAT) results using fresh and frozen stool specimens and rectal swabs - PubMed
Early diagnosis of monomicrobial Clostridioides difficile bacteremia in a patient without colitis - PubMed
Early diagnosis of monomicrobial Clostridioides difficile bacteremia in a patient without colitis - PubMed
Bacteremia is a rare finding among Clostridioides difficile infections. We describe a case of a 67-year-old man with resected colorectal cancer with colostomy who presented with small bowel obstruction and was admitted for lysis of adhesions. On day 8 of admission, he developed leukocytosis a …
·pubmed.ncbi.nlm.nih.gov·
Early diagnosis of monomicrobial Clostridioides difficile bacteremia in a patient without colitis - PubMed
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https://news.google.com/rss/articles/CBMilQFodHRwczovL3d3dy5waGFybWFjeXByYWN0aWNlbmV3cy5jb20vUmV2aWV3LUFydGljbGVzL0FydGljbGUvMTItMjMvS2VlcGluZy1VcGRhdGVkLW9uLUNsaW5pY2FsLVJhcGlkLURpYWdub3N0aWMtVGVzdHMtZm9yLUJhY3RlcmVtaWEtYW5kLUJleW9uZC83MjEwOdIBAA?oc=5
Rapid detection of gastrointestinal pathogens using a multiplex polymerase chain reaction gastrointestinal panel and its role in antimicrobial stewardship - PubMed
Rapid detection of gastrointestinal pathogens using a multiplex polymerase chain reaction gastrointestinal panel and its role in antimicrobial stewardship - PubMed
Paediatric diarrhoea patients showed higher positivity rates than adult patients. Application of FAGIP for acute diarrhoea might lower unnecessary antimicrobial use.
·pubmed.ncbi.nlm.nih.gov·
Rapid detection of gastrointestinal pathogens using a multiplex polymerase chain reaction gastrointestinal panel and its role in antimicrobial stewardship - PubMed
Prevalence of diagnostically-discrepant Clostridioides difficile clinical specimens: insights from longitudinal surveillance - PubMed
Prevalence of diagnostically-discrepant Clostridioides difficile clinical specimens: insights from longitudinal surveillance - PubMed
Our study highlights the dominance of Toxin EIA-negative CDI specimens in a clinical setting and the high frequency of known virulent ribotypes in these specimens. Therefore, a careful reevaluation of the clinical relevance of diagnostically-discrepant specimens particularly in the context of missed …
·pubmed.ncbi.nlm.nih.gov·
Prevalence of diagnostically-discrepant Clostridioides difficile clinical specimens: insights from longitudinal surveillance - PubMed