C Diff Diet

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Mounting evidence suggests that ingestive behaviors may also be affected by putative interplays between taste and gut microbiota. As yet empirically u…

Diets rich in fiber may provide health benefits and regulate the gut microbiome, which affects the immune system. However, the role of dietary fiber in Clostridioides difficile infection (CDI) is controversial. Here, we investigated the use of fermentable fibers, such as inulin or pectin, to …

The gut microbiota has been involved in mastitis. Scientists showed for the first time evidence that subclinical mastitis may be associated with a pro-inflammatory diet and women with subclinical mastitis have lower intakes of anti-inflammatory nutrients https://t.co/cwbSOlajXI— GutMicrobiota Health (@GMFHx) November 28, 2022

This article summarizes major highlights on diet and gut microbiome interactions of relevance for irritable bowel syndrome.

Diet can shape mucosal immunity. Dairy starters and fermented dairy products modulate gut mucosal immunity https://t.co/GnwxtvfbKl— GutMicrobiota Health (@GMFHx) November 23, 2022

Elderly Japanese patients with a high geriatric nutritional risk index (GNRI) were associated with significantly better Clostridioides difficile infection (CDI) relapse-free survival compared with those with low GNRI.

Here's everything you need to know about shopping for the best probiotic foods.

AbstractBackground and Aims. Ultra-processed food (UPF) consumption has been linked to globally increasing incidence and prevalence in chronic diseases includin

Thank you for sharing @ProfWhelan! These new findings suggest that when it comes to the gut microbiome, a safe food additive with a long history of use doesn't mean it is 100% healthy or inert (as it happens with artificial sweeteners).— GutMicrobiota Health (@GMFHx) November 18, 2022

Recent studies suggest that the intestinal microbiota is altered in patients with Alzheimer's disease. @Lauriemcox & colleagues update the role of probiotic and dietary interventions to prevent or treat Alzheimer's disease https://t.co/kj3GUYhDP9 pic.twitter.com/l4TwhkMrQR— GutMicrobiota Health (@GMFHx) November 18, 2022

Objective: Old age is a risk factor for Clostridioides difficile infection (CDI). As the world's aging population increases, identifying risk factors for CDI in elderly patients is a matter of urgency. This study examined the relationship between CDI relapse and nutritional status usin …

Dietary fibers can exert beneficial anti-inflammatory effects through short-chain fatty acids. New findings in mice show dietary inulin fiber triggers microbiota-derived cholic acid & type 2 inflammation at barrier surfaces with implications for allergies https://t.co/1Gn92PImtd— GutMicrobiota Health (@GMFHx) November 15, 2022

Objective Microbiome and dietary manipulation therapies are being explored for treating ulcerative colitis (UC). We aimed to examine the efficacy of multidonor faecal microbiota transplantation (FMT) and anti-inflammatory diet in inducing remission followed by long-term maintenance with anti-inflammatory diet in patients with mild-moderate UC. Design This open-labelled randomised controlled trial (RCT) randomised patients with mild-moderate (Simple Clinical Colitis Activity Index (SCCAI) 3–9) endoscopically active UC (Ulcerative Colitis Endoscopic Index of Severity (UCEIS)1) on stable baseline medications in 1:1 ratio to FMT and anti-inflammatory diet (FMT-AID) versus optimised standard medical therapy (SMT). The FMT-AID arm received seven weekly colonoscopic infusions of freshly prepared FMT from multiple rural donors(weeks 0–6) with anti-inflammatory diet. Baseline medications were optimised in the SMT arm. Clinical responders (decline in SCCAI3) at 8 weeks in both arms were followed until 48 weeks on baseline medications (with anti-inflammatory diet in the FMT-AID arm). Primary outcome measures were clinical response and deep remission (clinical—SCCAI 2; and endoscopic—UCEIS 1) at 8 weeks, and deep remission and steroid-free clinical remission at 48 weeks. Results Of the 113 patients screened, 73 were randomised, and 66 were included in (35—FMT-AID; 31—SMT) modified intention-to-treat analysis (age—35.7±11.1 years; male—60.1%; disease duration—48 (IQR 24–84) months; pancolitis—34.8%; SCCAI—6 (IQR 5–7); UCEIS—4 (IQR 3–5)). Baseline characteristics were comparable. FMT-AID was superior to SMT in inducing clinical response (23/35 (65.7%) vs 11/31 (35.5%), p=0.01, OR 3.5 (95% CI 1.3 to 9.6)), remission (21/35 (60%) vs 10/31 (32.3%), p=0.02, OR 3.2 (95% CI 1.1 to 8.7)) and deep remission (12/33 (36.4%) vs 2/23 (8.7%), p=0.03, OR 6.0 (95% CI 1.2 to 30.2)) at 8 weeks. Anti-inflammatory diet was superior to SMT in maintaining deep remission until 48 weeks (6/24 (25%) vs 0/27, p=0.007). Conclusion Multidonor FMT with anti-inflammatory diet effectively induced deep remission in mild-moderate UC which was sustained with anti-inflammatory diet over 1 year. Trial registration number [ISRCTN15475780][1]. Data are available upon reasonable request. [1]: /external-ref?link_type=ISRCTN&access_num=ISRCTN15475780

Nature Medicine - In a clinical trial, non-nutritive sweeteners — which are supposedly inert — were shown to disrupt the gut microbiome of healthy people and impair glucose tolerance.

Isotope tracing into bacterial-specific protein sequences allows for a determination of nutrient preferences across gut microbes in vivo, and it reveals how diet alters microbiome composition.

Nutritional supplementation can prevent antibiotic-induced GVHD in preclinical models, according to a study

The etiopathogenesis of multiple sclerosis (MS) is strongly affected by environmental factors such as diet and the gut microbiota. An isoflavone-rich (ISO) diet was previously shown to reduce the s...

Dietary supplementation may improve antibiotic-induced GVHD following stem cell transplantsLearn more: https://t.co/MYJluqF4ui @CellCellPress @MDAndersonNews #GVHD #alloHSCT #oralxylose #Bacteroides #FMT #meded #eMednews— eMedEvents (@eMedEvents) October 3, 2022

This article clarifies the definition and health implications of the closely related terms fiber, MACs and prebiotics.

The diet and gut microbiota have been extensively interrogated as a fuel for gut inflammation in inflammatory bowel diseases (IBDs) in the last few years. Here, we review how specific nutrients, typically enriched in a Western diet, instigate or deteriorate experimental gut inflammation in a genetically susceptible host and we discuss microbiota-dependent and independent mechanisms. We depict the study landscape of nutritional trials in paediatric and adult IBD and delineate common grounds for dietary advice. Conclusively, the diet reflects a critical rheostat of microbial dysbiosis and gut inflammation in IBD. Dietary restriction by exclusive enteral nutrition, with or without a specific exclusion diet, is effectively treating paediatric Crohn’s disease, while adult IBD trials are less conclusive. Insights into molecular mechanisms of nutritional therapy will change the perception of IBD and will allow us to enter the era of precision nutrition. To achieve this, we discuss the need for carefully designed nutritional trials with scientific rigour comparable to medical trials, which also requires action from stake holders. Establishing evidence-based dietary therapy for IBD does not only hold promise to avoid long-term immunosuppression, but to provide a widely accessible therapy at low cost. Identification of dietary culprits disturbing gut health also bears the potential to prevent IBD and allows informed decision making in food politics.

Fettig et al. provide evidence that a specific dietary fiber, guar gum, can delay onset of MS-like symptoms in mice via impaired Th1 polarization and CD4+ T cell recruitment to the central nervous system.

### Key messages The potential role of ‘leaky gut’ or reduced barrier function with increased intestinal permeability has been considered an important factor in intestinal and extraintestinal diseases. Reversing the impairment of barrier function in diseases associated with mucosal damage may be necessary but may not be sufficient to reverse the disease pathogenesis as in inflammatory bowel disease (IBD) or coeliac disease. In these diseases, the underlying immune dysfunction is likely to be a significant factor in perpetuating the disease. Nevertheless, gastrointestinal and extraintestinal diseases that are not associated with predominant inflammation in the small intestine or colon have drawn attention to the potential role of reduced barrier function in disease pathogenesis. These illnesses range from eosinophilic esophagitis to non-alcoholic fatty liver disease and to diverse neuropsychiatric diseases, as summarised elsewhere.1 There are also diverse systemic consequences associated with gut barrier dysfunction including increased inflammation or oxidative stress and decreased insulin sensitivity affecting tissues or organs such as the liver, fat, skeletal, muscle …

I see your point, @guthealthmd Specific microbiome target desirableI see “curated” #FMT or #phage therapy (maybe AIEC targeted) as the best alternatives in the future, not much faith in probiotics in CD. Diet always a key adjuvantFor now, Metro well documented in POR imho— ignacio catalan (@ign76) September 20, 2022

Scientists have discovered a fungus that delays wound healing in mice and is enriched in inflamed tissue from patients with Crohn’s disease.

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain and an altered defecation p…

According to a recent study published in the journal Cell Reports, a diet rich in soy protein increases human Clostridioides difficile susceptibility by increasing the gut amino acids (AAs) levels and promoting the growth of Lactobacillus.