C Diff Drug Stewardship

The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects.

Among common empiric antibiotics, parenteral vancomycin and cefepime appeared to increase risk of hospital-onset CDI. Causal inference observational study designs can be used to estimate patient-level harms of interventions such as empiric antimicrobials.

We demonstrated favorable clinical and safety outcomes with our COpAT program and substantial cost savings using existing infrastructure. COpAT allows efficient use of healthcare resources including decongestion of hospitals.

The DASC score within 30 days before CDI diagnosis appears to be a predictive risk factor for CDI recurrence.

Appropriate meropenem de-escalation in FN patients is safe and can result in improved clinical outcomes.

Microbiota encompasses a diverse array of microorganisms inhabiting specific ecological niches. Gut microbiota significantly influences physiological processes, including gastrointestinal motor function, neuroendocrine signalling, and immune regulation. They play a crucial role in modulating the cen …

Groundbreaking Phase 2 data shows VE303 bacterial treatment dramatically cuts C. difficile infection recurrence through multiple mechanisms. Phase 3 trial underway.

Implementing an order set significantly improved inpatient antibiotic prescribing for CAP with no difference in clinical or safety outcomes. Antibiotic order sets will be a useful tool for antimicrobial stewardship program expansion into other common community-acquired infections.

Significant value can be offered through the incorporation of stewardship concepts into infection guidelines, but we must also address the risk and challenges it may impose on health care systems.

Optimizing antimicrobial use in palliative oncology care requires a multidisciplinary approach that prioritizes patient-centered goals, minimizes harm, and addresses misconceptions about antibiotic efficacy in end-of-life care. Antimicrobial stewardship programs, when tailored to palliative settings …

A decrease in outpatient antibiotic prescriptions with known risk of developing CDI was associated with a decrease in hospital CDI admission prevalence. Our ecological analysis indicates that rational and restrained antibiotic use in the outpatient setting may reduce the incidence of CDI in the popu …

Mary Rochelle Smith, MD, Julie J Lee, MD, and Amy Chang, MD, PharmD, share expert strategies for implementing effective clinical decision support tools in practice.

CDI recurrence rates among cancer patients remain significant. Nonetheless, fidaxomicin and other preventive strategies are seldom used. We identified several factors that could inform the implementation of these strategies in cancer patients.

Ceftriaxone and metronidazole showed non-inferior outcomes to piperacillin/tazobactam for treating complicated diverticulitis.

For many common infectious diseases in both adult and pediatric populations, a significant body of evidence now shows that short-course antimicrobials are just as effective as long courses.

In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final versi …

Assessing antimicrobial treatment using DASC before CDI can predict recurrence and should facilitate the selection of initial therapy for CDI.

This toolkit provides a step-by-step guide to improving the medication reconciliation process.

In this instrumental variable analysis of community-dwelling older adults, longer antibiotic courses were not associated with an increased benefit or harm compared to shorter courses.

PCPs from clinics assigned to a low-intensity intervention combining comparative feedback with adverse event notifications had lower antibiotic prescription rates.

Antimicrobial resistance is a growing global concern, exacerbated by inappropriate and excessive use of antimicrobials.

Assessing antimicrobial treatment using DASC before CDI can predict recurrence and should facilitate the selection of initial therapy for CDI.

This feasibility study showed reductions in antibiotic prescribing for acute respiratory tract infections, emphasizing the efficacy of targeted, educator-led programs. Tailored healthcare strategies are vital, especially in Croatia and southeastern Europe, for promoting sustainable practices and add …

This annual review is intended to be a reference to describe the potential in vivo activity of various antimicrobial agents when the identity of the infecting ...

Monash University has secured over $49 million in funding for 40 projects in the latest round of NHMRC Ideas Grants - more than any other university

Broad-spectrum antibiotics were related to an increased risk for adverse drug events among adults with CAP who were treated in the outpatient setting.

Pharmacists play a crucial role in promoting the appropriate use of broad-spectrum antibiotics to prevent antimicrobial resistance and improve patient outcomes.

A shorter duration of venetoclax treatment for newly diagnosed acute myeloid leukemia (AML) may enhance efficacy and reduce toxicity, according to Amir Ali, PharmD, BCOP.

Introduction The use of antibiotics such as oral clindamycin has been effective in treating bacterial infections. However, this medication often comes with significant side effects, particula...