C Diff Drug Stewardship

Low-cost interventions were initially successful in changing patterns of antibiotic use and decreasing overall antibiotic prescribing among older patients in the outpatient setting. Long-term follow-up studies are needed to determine the sustainability and clinical impact of these interventions.

Antibiotics are crucial in treating many conditions but giving them to kids when they’re unnecessary can do more harm than good. Here’s why.

Adequately controlling the source of infection and prescribing appropriately antibiotic therapy are the cornerstones of the management of patients with intra-abdominal infections (IAIs). Correctly classifying patients with IAIs is crucial to assessing the severity of their clinical condition and dec …

This study demonstrated that reduced fluoroquinolone use in a large healthcare system was associated with increased usage of broad-spectrum cephalosporins, decreased CDI and improvements in resistance patterns.

NSAIDs do not increase the risk for Clostridioides difficile infection, according to a retrospective review of nearly 1,500 people.https://t.co/oIYcXQKmMl @ORMgmtNews #cdiff #NSAIDs— General Surgery News (@gensurgnews) October 26, 2022

Perioperative infection prophylaxis is a fundamental element of total knee arthroplasty (TKA). There has been a recent trend toward the use of extended postoperative oral antibiotics in high-risk patients. We describe a case report of a patient who underwent a primary TKA and subsequently developed …

Although there is a scarcity of studies involving SOT patients, current available data suggests that the use of RDTs helps improve patient outcomes and minimizes inappropriate antimicrobial use when coupled with proactive ASPs. Future studies should focus on clinical outcomes in SOT patients specifi …

SOT, antimicrobial stewardship program, MDRO, Clostridioides difficile infection, Centers for Disease Control and Prevention, Infectious Diseases Society of America, prospective audit and feedback, hematopoietic cell transplant, cytomegalovirus, trimethoprim-sulfamethoxazole, surgical site infection …

This study represents one of the first reports of AU in SOTr utilizing the NHSN-AU framework. More studies are needed for further peer-to-peer comparison of AU in this complex patient population.

There are known harms associated with antibiotics and, when studied, existing data do not demonstrate harm associated with shorter courses of antibiotics among SOTRs. Furthermore, several RCTs did include some immune compromised patients and found shorter therapy to result in similar clinical effica …

Antimicrobial stewardship programs (ASPs) have been shown to reduce the rates of antimicrobial resistance and improve morbidity and mortality in surgical patients. ASPs have largely been underutilized in solid organ transplant programs, and the current state of ASPs in transplantation is reviewed. C …

Significant variation exists in the adoption of ASP leading practices. A minority of hospitals have taken action to optimize diagnostic testing and measure adherence to FSTGs. Additional efforts are needed to expand adoption of leading practices across all acute-care hospitals with the greatest need …

Johnson: Many risk factors for C. difficile recurrence are non-modifiable, but as healthcare professionals we should avoid the indiscriminate use of antibiotics @esnm_eu #GMFHCoverage pic.twitter.com/OzonKBIxHm— GutMicrobiota Health (@GMFHx) October 12, 2022

At the 2022 AAP National Conference & Exhibition in Anaheim, California, Rana E. El Feghaly, MD, MSCI, associate professor, University of Missouri-Kansas City, Children's Mercy Kansas City, Missouri, led a session on how pediatric clinicians can employ best practices when prescribing medications for common childhood infections.

UK National Institute for Health and Care Research.

Background: Patients with hematologic malignancies frequently develop febrile neutropenia (FN) and subsequently receive long courses of broad-spectrum antibiotics. Limited data is available on de-escalation strategies. Methods: This was a retrospective observational cohort study of adu …

Our systemwide intervention reduced inpatient fluoroquinolone use immediately, but not HO-CDI. However, a downward trend in PD-CDI occurred. Relying on outcome measures limited to the inpatient setting may not reflect the full impact of inpatient stewardship efforts.

Impact of suppressing ciprofloxacin susceptibility results on antibiotic utilization and hospital-acquired Clostridioides difficile infection

Efforts to improve antimicrobial prescribing are occurring within a changing healthcare landscape, which includes the expanded use of telehealth technology. The wider adoption of telehealth presents both challenges and opportunities for promoting antimicrobial stewardship. Telehealth provides 2 aven …

There was a lower adjusted risk of severe CDI but not total CDI associated with vedolizumab. CMVC was not observed after initiating vedolizumab. These findings may provide reassurance regarding the use of vedolizumab when also considering the risk of gastrointestinal infections.

A new testing tool helps doctors avoid unnecessary antibiotic treatment in patients with diarrhea and suspected C. diff infection.

This ecological study is the largest to date examining the association between rates of antibiotic use (AU) and hospital-onset (HO) Clostridioides difficile infection (CDI) in a tertiary university hospital in Serbia. There was no clear trend in the incidence of HO-CDI over time. Total utiliz …

Scientists at EMBL and Cambridge University elucidate how common drugs accumulate in gut bacteria and potentially reduce medication’s effectiveness.

The human gut is a vast, complex ecosystem wherein bacteria, nutrients, and host cells interact intricately to maintain gut homeostasis and support host development. Disturbance in the gut ecology...

t study using prospectively collected historical data of all individuals born in Denmark between 1995 and 2018. We identified mebendazole exposure at age

Corticosteroid therapy during acute CDIs might impact the recurrence of CDIs, particularly in those with a lack of prior corticosteroid exposure.

The AS intervention was effective and safe in decreasing antibiotic consumption and LOS in the internal medicine area. Enabling prescribers to judicious use of antimicrobials through active participation in AS initiatives is key to reach sustained results over time.

In critically ill adults with aspiration pneumonia, our study found no difference in clinical failure based on the presence or absence of empiric anaerobic coverage adding to evolving literature suggesting that anaerobic coverage is not routinely warranted in this patient population. Interpretation …

Proton-pump inhibitors are a commonly prescribed anti-acid medication, but new guidelines from the American Gastroenterological Association recommend that they should be taken at the lowest ...