C Diff Drug Stewardship

Background The American Geriatrics Society 2019 Updated Beers Criteria© recommends avoiding scheduled use of proton pump inhibitors (PPIs) for greater than eight weeks in older people because of potential risk of bone loss and fractures and Clostridioides difficile infection. There …

Probiotics have been used for decades to alleviate the negative side-effects of oral antibiotics, but our mechanistic understanding on how they work is so far incomplete. Here, we performed a metag...

Six respiratory infections are among the most common diagnoses for which antibiotics often are inappropriately prescribed, and new research sheds light on the effects, both in increased risk of adverse events and excess health care costs.

Standard infusion group had more patients with P. aeruginosa isolates from blood and respiratory cultures, ICU status at the start of therapy and longer duration of treatment.

Comprehensive, nonoperative management of PFD including pelvic floor muscle training, biofeedback, electrogalvanic stimulation, constipation management, behavioral modification, incontinence devices, and pharmacotherapy including vaginal estrogen is effective in the treatment of women with PFD.

Over the first 2 years of the pandemic, global antibiotic sales increases were linked with rises in COVID-19 cases.

Clostridioides difficile infection (CDI) is common after allogeneic hematopoietic cell transplantation (alloHCT). The determination of incidence, risk factors, and impact of CDI on alloHCT outcomes is an unmet need. The study examines all patients aged 2 years and older who received first alloHCT fo …

As long as I can recall, I have suffered from stomach pain and intense bloating. In 2018, I began my journey of looking for relief to these symptoms which would lead me down the dark road of contracting recurrent, antibiotic resistant C. diff at the young age of 27. I …

The use of levofloxacin was shown to be safe in the induction phase in children with de novo ALL. The use of this medication did not increase the rate of colonization by CPE nor the rate of diarrhea by C. difficile. All adverse reactions were mild and remitted either spontaneously or after switching …

Older age and use of various medications, including antibiotics, proton pump inhibitors, and corticosteroids were associated with a higher risk of developing C difficile infections.

Conflicting evidence exists on the association between consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and symptomatic worsening of inflammatory bowel disease (IBD). We hypothesized t...

Almost one-third of UTI diagnoses and half of treatments in hospitalized patients with NB are inappropriate. Opportunities exist to improve ASB and UTI management in patients with NB to minimize inappropriate antibiotic use.

Over a 4-year period, the antimicrobial stewardship team reviewed all positive (PCR+/Tox+) and indeterminate (PCR+/Tox-) cases with the most responsible physician for classification of patients as infection or colonization. Among 501 indeterminate samples, 213 (43%) were considered to be clinical in …

A new study from Washington University in St. Louis and The Pew Charitable Trusts analyzing private health insurance claims data found that inappropriate antibiotic prescribing among adults diagnosed with common outpatient upper respiratory infections resulted in close to $69 million in excess health care costs in the U.S. in 2017 ($49.6 million for pharyngitis, and $19.1 million for sinus infection).

We analyzed our challenging experience with a randomized controlled trial of misoprostol for prevention of recurrent C. difficile. Despite careful prescreening and thoughtful protocol modifications to facilitate enrollment, we closed the study early after enrolling just 7 participants over 3 years. …

: Broad-spectrum antibiotics are associated with antimicrobial resistance, Clostridioides difficile infection, invasive candidiasis, significant disturbance of the gut microbiome and may seriously impact outcomes in children with cancer or undergoing allogenic hematopoietic stem cell transpla …

Hospital lengths of stay, costs, and readmissions were all reduced after implementing an antimicrobial stewardship program.

Hospital lengths of stay, costs, and readmissions were all reduced after implementing an antimicrobial stewardship program.

It’s like the room is glowing & lighting up during important talk on #Cdiff 💩 post #clindamycin Rx by #dentists 🦷just 1 dose can do it! ⁦@PeggyFund⁩ ⁦@OSAPtweets⁩ ⁦@fdiworlddental⁩ ⁦@DentalCEAcademy⁩ ⁦@AmerDentalAssn⁩ ⁦@LBaddour1⁩ pic.twitter.com/z6Ogri5hjW— Debbie Goff (@idpharmd) January 22, 2023

Assessing the appropriate utilization of PPIs in terms of indication, dose, frequency, and route of administration during admission and discharge

💊👩‍🔬The New Dental Antibiotic Guidance is available for replay. Presented by @idpharmd Register for the On Demand Webinar here: https://t.co/4LXXaNDu5L. @PerioProtect #dentist #dental #dentistry #dental #antibioticstewardship #cdiff pic.twitter.com/0ni6VB54wE— Dental CE Academy™ (@DentalCEAcademy) January 9, 2023

The guideline panel reviewed the evidence, per bacteria, of the risk of SSIs in patients colonised with MDR-GNB before surgery and critically appraised the existing studies. Significant knowledge gaps were identified, and most questions were addressed by observational studies. Moderate to high risk …

Dr Greg Poland talks to Dr Debra Goff about what antibiotics are and why you shouldn't take them for a respiratory viral infection.

A high number of patients received intravenous broad-spectrum antibiotics in the emergency department without confirmed or suspected bacterial infections that were supported by microbiologic cultures, radiographic imaging, or other symptoms of infections. Most patients who were initially admitted to …

Overuse of antacids is associated with the development and recurrence of Clostridioides difficile infection (CDI). Discontinuation of unnecessary antacids for CDI management is advocated; however, the clinical pervasiveness on the discontinuation of antacids remains unclear. We conducted a single-ce …

Antimicrobial therapies are essential tools for transplant recipients who are at high risk for infectious complications. However, judicious use of antimicrobials is critical to preventing the development of antimicrobial resistance. Treatment of multidrug-resistant organisms is challenging and poten …

We examined risk associated with antibiotics used for Clostridioides difficile infection (CDI) at a single site from 2018 through 2020. Overall, 78 patients had nonrecurrent infections. Among inpatient antibiotics, intravenous meropenem had the highest CDI rate (3.56 per 1,000 days of therapy …

Objective To examine antibiotic use in long-term care residents at a VA skilled nursing facility. Design Quality improvement project. Setting Long-term care residents admitted to the Community Living Center of a Midwestern VA medical center. Patients Inclusion criteria we …

We detected no correlation between standardized antimicrobial administration ratios (SAARs) and healthcare facility-onset Clostridioides difficile infection (HO-CDI) rates in 102 acute-care Veterans Affairs medical centers over 16 months. SAARs may be useful for investigating trends in local …