C Diff Drug Stewardship

A4. Nurses are critical for advocating for appropriate care of the patient, from lines and drugs, to labs and tests. All of this can not only optimize abx use, but also protect patients from #AntimicrobialResistance and #cdiff #USAAW22 #IDTwitter— Jamie Wagner (@jwagsIDPharmD) November 16, 2022

HANYS' ASC proved an effective and well-received strategy for encouraging hospitals, particularly large, urban facilities, to take concrete steps to strengthen their antibiotic stewardship efforts and prepare for potential mandates requiring antibiotic usage tracking and reporting. However, a reduct …

#WAAW2022 Prof Mark Wilcox using a great visual to explain #cdiff colonisation risk and #AntimicrobialResistance and exponential benefit from reducing antibiotic use https://t.co/PCd0ssJpqP pic.twitter.com/bwFxmCp6AM— Elizabeth Beech MBE (@elizbeech) November 18, 2022

#WAAW now listening to Prof Mark Wilcox webinar #cdiff and why have case counts now increased nationally? This slide reflects what @NHSSW @UKHSA_SouthWest improvement collaborative learning is finding @TinaArn0ld @connieptimmins @ciosicb @KezHolden @SMatravers @ChaamKlinger https://t.co/y0jm4XF0cb pic.twitter.com/VFWKKN5WhZ— Elizabeth Beech MBE (@elizbeech) November 18, 2022

#antimicrobialstewardship NB for #CDI prevention @ESCMID #ClostridioidesDifficile study group =interdisciplinary group active in all aspects of #cdiff - join us for final 2022 webinar 7th December 4pm CET more https://t.co/WCfGjKrn5R @TAEscmid @iscm_micro @IDSIreland @RCSI_Micro https://t.co/WK9rh9CBjt— Prof. Fidelma Fitzpatrick (@FfitzP) November 17, 2022

#WAAW2022 really interesting data from @NHSSW and @ciosicb burden of #Cdiff infection in very elderly people esp men. Looks like largest N cases associated with skin and soft tissue infection and #antibiotics Opportunity to improve #antibioticstewardship in community https://t.co/0i7q0VWlHz— Elizabeth Beech MBE (@elizbeech) November 18, 2022

This study adds to a body of literature documenting increases in CLABSI and MRSA BSI incidence during the pandemic.

A4. Nurses are critical for advocating for appropriate care of the patient, from lines and drugs, to labs and tests. All of this can not only optimize abx use, but also protect patients from #AntimicrobialResistance and #cdiff #USAAW22 #IDTwitter— Jamie Wagner (@jwagsIDPharmD) November 16, 2022

Incubation for 14 days is recommended for the culture of microorganisms from osteoarticular infections (OAI), but there are no recommendations for postoperative antibiotic stewardship concerning empirical antimicrobial therapy (EAT), while prolonging broad-spectrum EAT results in adverse effects. Th …

Antibiotic exposure is a crucial risk factor for community-acquired Clostridioides difficile infection (CA-CDI). However, the relative risks associated with specific antibiotics may vary over time, and the absolute risks have not been clearly established. This is a retrospective cohort study. Adults …

One clinician discusses strategies in how his institution minimizes the wide spectrum approach to antibiotics as well as tries to prevent potential complications.

Inappropriate antibiotic prescriptions for respiratory infections were associated with increased risks of patient harm and higher health care expenditures, justifying a further call-to-action to implement outpatient antibiotic stewardship programs.

Post-procedural antibiotics were frequently prescribed after urologic procedures with large inter-facility variability even after adjusting for case-mix differences. Post-procedural antibiotic use was associated with increased risk for C. difficile infection but not fewer unplanned return visits. Ef …

The use of extended antibiotic (EA) prophylaxis ( 24 h) remains controversial in aseptic revision arthroplasty. We sought to determine whether EA prophylaxis reduces the risk of periprosthetic joint infection (PJI) in aseptic revision hip and knee arthroplasty. A total of 2800 patients undergoin …

It can develop while you're taking antibiotics. Learn when you need to talk to you doctor about it.

The use of extended antibiotic (EA) prophylaxis ( 24 h) remains controversial in aseptic revision arthroplasty. We sought to determine whether EA prophylaxis reduces the risk of periprosthetic joint infection (PJI) in aseptic revision hip and knee arthroplasty. A total of 2800 patients undergoin …

Antibiotics are crucial in treating many conditions but giving them to kids when they’re unnecessary can do more harm than good. Here’s why.

Utilization of an APBL for 72 hours was associated with a statistically significant increase in the incidence of CDI in an unadjusted model and with a numerically higher CDI incidence in the adjusted model. Meropenem was the formulary APBL that carried the highest risk of CDI. The results of thi …

Low-cost interventions were initially successful in changing patterns of antibiotic use and decreasing overall antibiotic prescribing among older patients in the outpatient setting. Long-term follow-up studies are needed to determine the sustainability and clinical impact of these interventions.

Antibiotics are crucial in treating many conditions but giving them to kids when they’re unnecessary can do more harm than good. Here’s why.

Adequately controlling the source of infection and prescribing appropriately antibiotic therapy are the cornerstones of the management of patients with intra-abdominal infections (IAIs). Correctly classifying patients with IAIs is crucial to assessing the severity of their clinical condition and dec …

This study demonstrated that reduced fluoroquinolone use in a large healthcare system was associated with increased usage of broad-spectrum cephalosporins, decreased CDI and improvements in resistance patterns.

NSAIDs do not increase the risk for Clostridioides difficile infection, according to a retrospective review of nearly 1,500 people.https://t.co/oIYcXQKmMl @ORMgmtNews #cdiff #NSAIDs— General Surgery News (@gensurgnews) October 26, 2022

Perioperative infection prophylaxis is a fundamental element of total knee arthroplasty (TKA). There has been a recent trend toward the use of extended postoperative oral antibiotics in high-risk patients. We describe a case report of a patient who underwent a primary TKA and subsequently developed …

Although there is a scarcity of studies involving SOT patients, current available data suggests that the use of RDTs helps improve patient outcomes and minimizes inappropriate antimicrobial use when coupled with proactive ASPs. Future studies should focus on clinical outcomes in SOT patients specifi …

SOT, antimicrobial stewardship program, MDRO, Clostridioides difficile infection, Centers for Disease Control and Prevention, Infectious Diseases Society of America, prospective audit and feedback, hematopoietic cell transplant, cytomegalovirus, trimethoprim-sulfamethoxazole, surgical site infection …

This study represents one of the first reports of AU in SOTr utilizing the NHSN-AU framework. More studies are needed for further peer-to-peer comparison of AU in this complex patient population.

There are known harms associated with antibiotics and, when studied, existing data do not demonstrate harm associated with shorter courses of antibiotics among SOTRs. Furthermore, several RCTs did include some immune compromised patients and found shorter therapy to result in similar clinical effica …