C Diff Drug Stewardship

A new testing tool helps doctors avoid unnecessary antibiotic treatment in patients with diarrhea and suspected C. diff infection.

This ecological study is the largest to date examining the association between rates of antibiotic use (AU) and hospital-onset (HO) Clostridioides difficile infection (CDI) in a tertiary university hospital in Serbia. There was no clear trend in the incidence of HO-CDI over time. Total utiliz …

Scientists at EMBL and Cambridge University elucidate how common drugs accumulate in gut bacteria and potentially reduce medication’s effectiveness.

The human gut is a vast, complex ecosystem wherein bacteria, nutrients, and host cells interact intricately to maintain gut homeostasis and support host development. Disturbance in the gut ecology...

t study using prospectively collected historical data of all individuals born in Denmark between 1995 and 2018. We identified mebendazole exposure at age

Corticosteroid therapy during acute CDIs might impact the recurrence of CDIs, particularly in those with a lack of prior corticosteroid exposure.

The AS intervention was effective and safe in decreasing antibiotic consumption and LOS in the internal medicine area. Enabling prescribers to judicious use of antimicrobials through active participation in AS initiatives is key to reach sustained results over time.

In critically ill adults with aspiration pneumonia, our study found no difference in clinical failure based on the presence or absence of empiric anaerobic coverage adding to evolving literature suggesting that anaerobic coverage is not routinely warranted in this patient population. Interpretation …

Proton-pump inhibitors are a commonly prescribed anti-acid medication, but new guidelines from the American Gastroenterological Association recommend that they should be taken at the lowest ...

Researchers assessed whether normal oxygenation is an indicator for the early discontinuation of antibiotic treatment in patients hospitalized with pneumonia.

Inappropriate antibiotic use and associated consequences, including pathogen resistance and Clostridioides difficile infection, continue to serve as significant threats in the United States, with increasing incidence in the community setting. While much attention has been granted towards anti …

Similar to studies demonstrating efficacy in immunocompetent patients, shorter antibiotic courses should be considered for immunocompromised hosts with presumed bacterial infections. Organ recipients and patients with neutropenic fever syndromes should be prioritized for study in randomized controll …

Implementation of antimicrobial stewardship-initiated restriction criteria can reduce inappropriate utilization of meropenem, overall number of orders, and total duration of therapy.

Long-term treatment of functional dyspepsia with proton-pump inhibitors can alter the gut microbiome. A new pilot randomized, double-blind, placebo-controlled trial suggests the potential of spore-forming probiotics in patients with functional dyspepsia.

Health systems and payers can protect patients by encouraging responsible prescribing

The use of antibiotic prophylaxis was associated with low rate of bacteremia in the pre-engraftment period and a 10% risk of C. diff infections. More studies are needed to better evaluate the efficacy of antibiotic prophylaxis in HSCT patients.

Ampicillin was associated with comparable clinical outcomes in comparison to ceftriaxone for patients who were hospitalized due to CAP. Ampicillin was associated with significantly lower rate of CDI. Results need to be confirmed by more robust study designs.

It has been over a year since the launch of Special Interest Groups (SIGs) in the Middle East and Africa by Oracle Cerner with over 10 sessions on various topics related to data analytics and clinical informatics.

Fantastic work from @USouthFlorida @USFHealth!Ever wondered why cephalosporin (CF) treatment promotes #Cdiff infection? In this multi-PI report (mainly Xingmin Sun and Yu Chen labs) we show the mechanistic details of CF resistance and Zn-binding PBPs.https://t.co/i9pWgdvZ8b— Prahathees Eswara ☀️🌴 (@Eswara_Lab) August 2, 2022

Proton pump inhibitor use was cited as the only avoidable risk factor for mortality in patients with Clostridioides difficile infection.

In 2020, resistant hospital-related infections and deaths increased at least 15%, CDC reports.

Objective To determine whether the long-term care facility (LTCF) Centers for Medicare & Medicaid Services (CMS) Antimicrobial Stewardship (AMS) mandate was associated with a change in the combined rate of LTCF-acquired multidrug-resistant organism infection or colonization (MDRO-I/C) and …

We observed no difference in treatment failure rates for patients receiving an oral BL compared to an oral FQ or SXT for step-down therapy of BSIs due to E. coli, K. pneumoniae, and P. mirabilis.

This retrospective single-center study included children aged 2 months to 18 years who were prescribed an oral antibiotic for microbiologically confirmed urinary tract infection (UTI). The primary outcomes were re-encounter to the hospital, emergency department, or urgent care within 30 days and mod …

Clostridioides difficile infection (CDI) is associated with high mortality rates among patients with chronic illnesses. We aimed to identify avoidable risk factors to reduce the mortality rate in CDI patients. A total of 306 patients with diarrhea and clinical suspicion of CDI were enrolled, and fec …

According to a survey, more than 70% of doctors said they would administer antibiotics to treat asymptomatic bacteria found in urine tests, disobeying recommended guidelines A study of primary care doctors found that, on the basis of a single positive urine sample, an estimated 70% of them would

C. diff survivor and Peggy Lillis Foundation Advocates Council member Christina talks about her experience with the disease, both her own battle and that of her daughter.